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Interleukin-10 (IL-10) inhibits Borrelia burgdorferi-induced IL-17 production and attenuates IL-17-mediated Lyme arthritis.
Hansen ES, Medić V, Kuo J, Warner TF, Schell RF, Nardelli DT. Hansen ES, et al. Infect Immun. 2013 Dec;81(12):4421-30. doi: 10.1128/IAI.01129-13. Epub 2013 Sep 16. Infect Immun. 2013. PMID: 24042116 Free PMC article.
Previous studies have shown that cells and cytokines associated with interleukin-17 (IL-17)-driven inflammation are involved in the arthritic response to Borrelia burgdorferi infection. Here, we report that IL-17 is a contributing …
Previous studies have shown that cells and cytokines associated with interleukin-17 (IL-17)-driven inflammation …
Borrelia-primed and -infected mice deficient of interleukin-17 develop arthritis after neutralization of gamma-interferon.
Kuo J, Warner TF, Schell RF. Kuo J, et al. Pathog Dis. 2017 Mar 1;75(2). doi: 10.1093/femspd/ftx014. Pathog Dis. 2017. PMID: 28175297
The immune mechanisms responsible for development of Lyme arthritis are partially understood with interleukin-17 (IL-17) and gamma-interferon (IFN-gamma) playing a generally accepted role. ...In addition, IL-17 and IFN-gamma have been imp …
The immune mechanisms responsible for development of Lyme arthritis are partially understood with interleukin-17 (IL- …
Arthritis is developed in Borrelia-primed and -infected mice deficient of interleukin-17.
Kuo J, Warner TF, Munson EL, Nardelli DT, Schell RF. Kuo J, et al. Pathog Dis. 2016 Oct;74(7):ftw077. doi: 10.1093/femspd/ftw077. Epub 2016 Aug 4. Pathog Dis. 2016. PMID: 27493062
Interleukin-17 (IL-17) has been shown to participate in the development of Lyme arthritis in experimental mice. ...We hypothesized that mice lacking IL-17 would fail to develop Borrelia-induced arthritis. IL-17-defici …
Interleukin-17 (IL-17) has been shown to participate in the development of Lyme arthritis in experimental mice. …
Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism.
Oosting M, van de Veerdonk FL, Kanneganti TD, Sturm P, Verschueren I, Berende A, van der Meer JW, Kullberg BJ, Netea MG, Joosten LA. Oosting M, et al. Eur J Immunol. 2011 Jan;41(1):172-81. doi: 10.1002/eji.201040385. Epub 2010 Dec 9. Eur J Immunol. 2011. PMID: 21182088 Free PMC article.
Caspase-1-deficient cells showed significantly less IFN-gamma and IL-17 production after Borrelia stimulation. A lack of IL-1beta was responsible for the defective IL-17 production, whereas IL-18 was crucial for the IFN-gamma produ …
Caspase-1-deficient cells showed significantly less IFN-gamma and IL-17 production after Borrelia stimulation. A lack o …
CD4+ cell-derived interleukin-17 in a model of dysregulated, Borrelia-induced arthritis.
Hansen ES, Johnson ME, Schell RF, Nardelli DT. Hansen ES, et al. Pathog Dis. 2016 Oct;74(7):ftw084. doi: 10.1093/femspd/ftw084. Epub 2016 Aug 21. Pathog Dis. 2016. PMID: 27549424
Here, we hypothesized that a murine model combining the dysregulated immune response of an environment lacking interleukin-10 (IL-10) with a robust T-cell-driven inflammatory response would reflect arthritis associated with the production of IL-17 by C …
Here, we hypothesized that a murine model combining the dysregulated immune response of an environment lacking interleukin-10 (IL …
Neuroimmunomodulators in Neuroborreliosis and Lyme Encephalopathy.
Eckman EA, Pacheco-Quinto J, Herdt AR, Halperin JJ. Eckman EA, et al. Clin Infect Dis. 2018 Jun 18;67(1):80-88. doi: 10.1093/cid/ciy019. Clin Infect Dis. 2018. PMID: 29340592
CONCLUSIONS: CSF CXCL13 is a sensitive and specific marker of neuroborreliosis in individuals with Borrelia-specific intrathecal antibody production. However, it does not distinguish individuals strongly suspected of having neuroborreliosis, but lacking confirmatory intrat …
CONCLUSIONS: CSF CXCL13 is a sensitive and specific marker of neuroborreliosis in individuals with Borrelia-specific intrathecal anti …
Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1.
Bachmann M, Horn K, Rudloff I, Goren I, Holdener M, Christen U, Darsow N, Hunfeld KP, Koehl U, Kind P, Pfeilschifter J, Kraiczy P, Mühl H. Bachmann M, et al. PLoS Pathog. 2010 Oct 14;6(10):e1001144. doi: 10.1371/journal.ppat.1001144. PLoS Pathog. 2010. PMID: 20976193 Free PMC article.
Thus, we sought to characterize the immediate cytokine storm associated with exposure of PBMC to moderate levels of live Borrelia burgdorferi. Since Th17 cytokines are connected to host defense against extracellular bacteria, we focused on interleukin (IL)- …
Thus, we sought to characterize the immediate cytokine storm associated with exposure of PBMC to moderate levels of live Borrelia bur …
Attenuation of relapsing fever neuroborreliosis in mice by IL-17A blockade.
Cheng M, Xu J, Ding K, Zhang J, Lu W, Liu J, Gao J, Alugupalli KR, Liu H. Cheng M, et al. Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2205460119. doi: 10.1073/pnas.2205460119. Epub 2022 Oct 10. Proc Natl Acad Sci U S A. 2022. PMID: 36215473 Free PMC article.
RNA sequencing analysis of the spinal cord tissue during the disease phase revealed an association of the interleukin (IL)-17 signaling pathway in RFNB. To test a possible role for IL-17 in RFNB, we compared B. hermsii infection in wild-type and …
RNA sequencing analysis of the spinal cord tissue during the disease phase revealed an association of the interleukin (IL)- …
Role of interleukin-23 (IL-23) receptor signaling for IL-17 responses in human Lyme disease.
Oosting M, ter Hofstede H, van de Veerdonk FL, Sturm P, Kullberg BJ, van der Meer JW, Netea MG, Joosten LA. Oosting M, et al. Infect Immun. 2011 Nov;79(11):4681-7. doi: 10.1128/IAI.05242-11. Epub 2011 Sep 6. Infect Immun. 2011. PMID: 21896776 Free PMC article.
Interleukin-23 (IL-23) is known to play a crucial role in the development and maintenance of T helper 17 cells. It has been previously demonstrated that IL-17 is involved in experimental Lyme arthritis, caused by Borrelia burgdorferi bact …
Interleukin-23 (IL-23) is known to play a crucial role in the development and maintenance of T helper 17 cells. It has …
Interleukin-35 enhances Lyme arthritis in Borrelia-vaccinated and -infected mice.
Kuo J, Nardelli DT, Warner TF, Callister SM, Schell RF. Kuo J, et al. Clin Vaccine Immunol. 2011 Jul;18(7):1125-32. doi: 10.1128/CVI.00052-11. Epub 2011 May 25. Clin Vaccine Immunol. 2011. PMID: 21613457 Free PMC article.
Interleukin-35 (IL-35) has been reported to inhibit the production of interleukin-17 (IL-17) as a means of preventing arthritis and other inflammatory diseases. ...We hypothesized that IL-35 would reduce the severity of arthritis b …
Interleukin-35 (IL-35) has been reported to inhibit the production of interleukin-17 (IL-17) as a …
43 results