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Rapid clearance of Borrelia burgdorferi from the blood circulation.
Liang L, Wang J, Schorter L, Nguyen Trong TP, Fell S, Ulrich S, Straubinger RK. Liang L, et al. Parasit Vectors. 2020 Apr 21;13(1):191. doi: 10.1186/s13071-020-04060-y. Parasit Vectors. 2020. PMID: 32312278 Free PMC article.
BACKGROUND: Borrelia burgdorferi is a tick-borne spirochete that causes Lyme borreliosis (LB). ...METHODS: In this study, we established a strict intravenous infection murine model using host-adapted spirochetes. Survival capacity and infectivity of host
BACKGROUND: Borrelia burgdorferi is a tick-borne spirochete that causes Lyme borreliosis (LB). ...METHODS: In this study, we establis …
Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques.
Crossland NA, Alvarez X, Embers ME. Crossland NA, et al. Am J Pathol. 2018 Mar;188(3):672-682. doi: 10.1016/j.ajpath.2017.11.005. Epub 2017 Dec 12. Am J Pathol. 2018. PMID: 29242055 Free PMC article.
Rare morphologically intact spirochetes were observed in the brains of two treated rhesus macaques, the heart of one treated rhesus macaque, and adjacent to a peripheral nerve of an untreated animal. Borrelia antigen staining of probable spirochete cross sections was also …
Rare morphologically intact spirochetes were observed in the brains of two treated rhesus macaques, the heart of one treated rhesus macaque, …
Deletion of a Genetic Region of lp17 Affects Plasmid Copy Number in Borrelia burgdorferi.
Wong JK, Crowley MA, Bankhead T. Wong JK, et al. Front Cell Infect Microbiol. 2022 Apr 12;12:884171. doi: 10.3389/fcimb.2022.884171. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35493747 Free PMC article.
Borrelia burgdorferi, the Lyme disease pathogen, is maintained in its enzootic life cycle through complex gene regulatory pathways encoded on its uniquely fragmented genome. ...Additionally, we compared lp17 copy number between in vitro and mammalian host-adapted
Borrelia burgdorferi, the Lyme disease pathogen, is maintained in its enzootic life cycle through complex gene regulatory pathways en
Homologous and heterologous Borrelia burgdorferi challenge of infection-derived immune rabbits using host-adapted organisms.
Shang ES, Wu XY, Lovett MA, Miller JN, Blanco DR. Shang ES, et al. Infect Immun. 2001 Jan;69(1):593-8. doi: 10.1128/IAI.69.1.593-598.2001. Infect Immun. 2001. PMID: 11119560 Free PMC article.
We have recently found that strain B31 infection-immune rabbits are completely protected against homologous challenge with large numbers (>10(6)) of host-adapted Borrelia burgdorferi (HAB) (E. S. Shang, C. I. Champion, X. ...
We have recently found that strain B31 infection-immune rabbits are completely protected against homologous challenge with large numbers (&g …
The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host.
Eggers CH, Caimano MJ, Malizia RA, Kariu T, Cusack B, Desrosiers DC, Hazlett KR, Claiborne A, Pal U, Radolf JD. Eggers CH, et al. Mol Microbiol. 2011 Nov;82(3):679-97. doi: 10.1111/j.1365-2958.2011.07845.x. Epub 2011 Oct 12. Mol Microbiol. 2011. PMID: 21923763 Free PMC article.
In a microarray analysis of the RpoS regulon in mammalian host-adapted Borrelia burgdorferi, bb0728 (cdr) was found to be dually transcribed by the sigma factors sigma(70) and RpoS. ...
In a microarray analysis of the RpoS regulon in mammalian host-adapted Borrelia burgdorferi, bb0728 (cdr) was found to …
Identification of Surface Epitopes Associated with Protection against Highly Immune-Evasive VlsE-Expressing Lyme Disease Spirochetes.
Batool M, Caoili SEC, Dangott LJ, Gerasimov E, Ionov Y, Piontkivska H, Zelikovsky A, Waghela SD, Rogovskyy AS. Batool M, et al. Infect Immun. 2018 Jul 23;86(8):e00182-18. doi: 10.1128/IAI.00182-18. Print 2018 Aug. Infect Immun. 2018. PMID: 29866906 Free PMC article.
The tick-borne pathogen Borrelia burgdorferi is responsible for approximately 300,000 Lyme disease (LD) cases per year in the United States. ...Toward the identification, we repeatedly immunized immunocompetent mice with live-attenuated VlsE-deleted B. burgdorferi and then …
The tick-borne pathogen Borrelia burgdorferi is responsible for approximately 300,000 Lyme disease (LD) cases per year in the United …
Variable VlsE is critical for host reinfection by the Lyme disease spirochete.
Rogovskyy AS, Bankhead T. Rogovskyy AS, et al. PLoS One. 2013 Apr 8;8(4):e61226. doi: 10.1371/journal.pone.0061226. Print 2013. PLoS One. 2013. PMID: 23593438 Free PMC article.
A key mechanism for immune evasion and persistent infection by the Lyme disease spirochete, Borrelia burgdorferi, is antigenic variation of the VlsE surface protein. ...To address this, the requirement of VlsE for host reinfection by the Lyme disease pathogen was investiga …
A key mechanism for immune evasion and persistent infection by the Lyme disease spirochete, Borrelia burgdorferi, is antigenic variat …
Molecular adaptation of Borrelia burgdorferi in the murine host.
Liang FT, Nelson FK, Fikrig E. Liang FT, et al. J Exp Med. 2002 Jul 15;196(2):275-80. doi: 10.1084/jem.20020770. J Exp Med. 2002. PMID: 12119353 Free PMC article.
An analysis of expression of 137 lipoprotein genes on the course of murine infection revealed a two-step molecular adaptation by Borrelia burgdorferi, the Lyme disease spirochete. For the first step, regardless whether the initial inocula of B. burgdorferi expressed either …
An analysis of expression of 137 lipoprotein genes on the course of murine infection revealed a two-step molecular adaptation by Borrelia
Changes in temporal and spatial patterns of outer surface lipoprotein expression generate population heterogeneity and antigenic diversity in the Lyme disease spirochete, Borrelia burgdorferi.
Hefty PS, Jolliff SE, Caimano MJ, Wikel SK, Akins DR. Hefty PS, et al. Infect Immun. 2002 Jul;70(7):3468-78. doi: 10.1128/IAI.70.7.3468-3478.2002. Infect Immun. 2002. PMID: 12065486 Free PMC article.
Borrelia burgdorferi differentially expresses many of the OspE/F/Elp paralogs during tick feeding. ...To examine why these apparently surface-exposed lipoproteins were not protective, we analyzed their genetic stability during infection and their cellular locations after c
Borrelia burgdorferi differentially expresses many of the OspE/F/Elp paralogs during tick feeding. ...To examine why these apparently
Protective and arthritis-resolving activity in sera of mice infected with Borrelia burgdorferi.
Barthold SW, Feng S, Bockenstedt LK, Fikrig E, Feen K. Barthold SW, et al. Clin Infect Dis. 1997 Jul;25 Suppl 1:S9-17. doi: 10.1086/516166. Clin Infect Dis. 1997. PMID: 9233658
Immune serum had very-high-titer passive protective activity against syringe challenge but failed to protect mice against host-adapted spirochetes when they were challenged with infected tissue transplants. ...
Immune serum had very-high-titer passive protective activity against syringe challenge but failed to protect mice against host-ada
45 results