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PlzA is a bifunctional c-di-GMP biosensor that promotes tick and mammalian host-adaptation of Borrelia burgdorferi.
Groshong AM, Grassmann AA, Luthra A, McLain MA, Provatas AA, Radolf JD, Caimano MJ. Groshong AM, et al. PLoS Pathog. 2021 Jul 15;17(7):e1009725. doi: 10.1371/journal.ppat.1009725. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34265024 Free PMC article.
In this study, we examined the relationship between c-di-GMP and its only known effector protein, PlzA, in Borrelia burgdorferi during the arthropod and mammalian phases of the enzootic cycle. ...Contrary to prior reports, loss of PlzA did not affect expression of RpoS or …
In this study, we examined the relationship between c-di-GMP and its only known effector protein, PlzA, in Borrelia burgdorferi durin …
Rapid clearance of Borrelia burgdorferi from the blood circulation.
Liang L, Wang J, Schorter L, Nguyen Trong TP, Fell S, Ulrich S, Straubinger RK. Liang L, et al. Parasit Vectors. 2020 Apr 21;13(1):191. doi: 10.1186/s13071-020-04060-y. Parasit Vectors. 2020. PMID: 32312278 Free PMC article.
Currently the exact dissemination pathway of LB pathogens in the host is not known and controversially discussed. METHODS: In this study, we established a strict intravenous infection murine model using host-adapted spirochetes. Survival capacity and infectiv …
Currently the exact dissemination pathway of LB pathogens in the host is not known and controversially discussed. METHODS: In this st …
OspC-independent infection and dissemination by host-adapted Borrelia burgdorferi.
Tilly K, Bestor A, Dulebohn DP, Rosa PA. Tilly K, et al. Infect Immun. 2009 Jul;77(7):2672-82. doi: 10.1128/IAI.01193-08. Epub 2009 Apr 27. Infect Immun. 2009. PMID: 19398538 Free PMC article.
Recipient mouse immune responses to tissue transfer-mediated infection with wild-type or ospC mutant spirochetes were similar. These experiments demonstrate that mammalian host-adapted spirochetes can infect and disseminate in mice in the absence of OspC, thereby ci …
Recipient mouse immune responses to tissue transfer-mediated infection with wild-type or ospC mutant spirochetes were similar. These experim …
Comparison of protection in rabbits against host-adapted and cultivated Borrelia burgdorferi following infection-derived immunity or immunization with outer membrane vesicles or outer surface protein A.
Shang ES, Champion CI, Wu XY, Skare JT, Blanco DR, Miller JN, Lovett MA. Shang ES, et al. Infect Immun. 2000 Jul;68(7):4189-99. doi: 10.1128/IAI.68.7.4189-4199.2000. Infect Immun. 2000. PMID: 10858236 Free PMC article.
While immunization with OspA and avirulent B31 OMV provided far less protection against this challenge, rabbits with infection-derived immunity were completely protected. Protection against host-adapted B. burgdorferi was assessed by implantation of skin biopsies ta …
While immunization with OspA and avirulent B31 OMV provided far less protection against this challenge, rabbits with infection-derived immun …
Generation of Mammalian Host-Adapted Borrelia burgdorferi by Cultivation in Peritoneal Dialysis Membrane Chamber Implantation in Rats.
Caimano MJ. Caimano MJ. Methods Mol Biol. 2018;1690:35-45. doi: 10.1007/978-1-4939-7383-5_3. Methods Mol Biol. 2018. PMID: 29032534 Free PMC article.
The transmission, survival, and virulence of Borrelia burgdorferi depend upon the spirochete's ability to modulate its transcriptome as it cycles between its arthropod vector and reservoir host. This complex adaptive process is collectively referred to as "host …
The transmission, survival, and virulence of Borrelia burgdorferi depend upon the spirochete's ability to modulate its transcriptome …
Cellular and immunological mechanisms influence host-adapted phenotypes in a vector-borne microparasite.
Lin YP, Tufts DM, Combs M, Dupuis AP 2nd, Marcinkiewicz AL, Hirsbrunner AD, Diaz AJ, Stout JL, Blom AM, Strle K, Davis AD, Kramer LD, Kolokotronis SO, Diuk-Wasser MA. Lin YP, et al. Proc Biol Sci. 2022 Feb 23;289(1969):20212087. doi: 10.1098/rspb.2021.2087. Epub 2022 Feb 23. Proc Biol Sci. 2022. PMID: 35193398
Predicting pathogen emergence and spillover risk requires understanding the determinants of a pathogens' host range and the traits involved in host competence. While host competence is often considered a fixed species-specific trait, it may be variable if pat …
Predicting pathogen emergence and spillover risk requires understanding the determinants of a pathogens' host range and the traits in …
Host-adapted Borrelia burgdorferi in mice expresses OspA during inflammation.
Crowley H, Huber BT. Crowley H, et al. Infect Immun. 2003 Jul;71(7):4003-10. doi: 10.1128/IAI.71.7.4003-4010.2003. Infect Immun. 2003. PMID: 12819088 Free PMC article.
We hypothesized that this was due to the inflammatory environment caused by the immune response to the spirochete. To test our hypothesis, we adapted an in vivo model that mimics the host-pathogen interaction. ...The results obtained by these techniques uniformly id …
We hypothesized that this was due to the inflammatory environment caused by the immune response to the spirochete. To test our hypothesis, w …
Immune evasion by tickborne and host-adapted Borrelia burgdorferi.
de Silva AM, Fikrig E, Hodzic E, Kantor FS, Telford SR 3rd, Barthold SW. de Silva AM, et al. J Infect Dis. 1998 Feb;177(2):395-400. doi: 10.1086/514200. J Infect Dis. 1998. PMID: 9466527
Immune sera from mice infected with the Lyme disease spirochete, Borrelia burgdorferi, have strong biologic activity against spirochetes cultured in vitro. ...Immune sera did not protect mice from tickborne spirochetes or spirochetes derived from infected mice. These resul …
Immune sera from mice infected with the Lyme disease spirochete, Borrelia burgdorferi, have strong biologic activity against spiroche …
Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals.
Mulay VB, Caimano MJ, Iyer R, Dunham-Ems S, Liveris D, Petzke MM, Schwartz I, Radolf JD. Mulay VB, et al. J Bacteriol. 2009 Apr;191(8):2783-94. doi: 10.1128/JB.01802-08. Epub 2009 Feb 13. J Bacteriol. 2009. PMID: 19218390 Free PMC article.
Although BBA74 initially was described as a 28-kDa virulence-associated outer-membrane-spanning protein with porin-like function, subsequent studies revealed that it is periplasmic and downregulated in mammalian host-adapted spirochetes. To further elucidate the rol …
Although BBA74 initially was described as a 28-kDa virulence-associated outer-membrane-spanning protein with porin-like function, subsequent …
Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques.
Crossland NA, Alvarez X, Embers ME. Crossland NA, et al. Am J Pathol. 2018 Mar;188(3):672-682. doi: 10.1016/j.ajpath.2017.11.005. Epub 2017 Dec 12. Am J Pathol. 2018. PMID: 29242055 Free PMC article.
Rare morphologically intact spirochetes were observed in the brains of two treated rhesus macaques, the heart of one treated rhesus macaque, and adjacent to a peripheral nerve of an untreated animal. Borrelia antigen staining of probable spirochete cross sections was also …
Rare morphologically intact spirochetes were observed in the brains of two treated rhesus macaques, the heart of one treated rhesus macaque, …
42 results