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Generation of Mammalian Host-Adapted Borrelia burgdorferi by Cultivation in Peritoneal Dialysis Membrane Chamber Implantation in Rats.
Caimano MJ. Caimano MJ. Methods Mol Biol. 2018;1690:35-45. doi: 10.1007/978-1-4939-7383-5_3. Methods Mol Biol. 2018. PMID: 29032534 Free PMC article.
The transmission, survival, and virulence of Borrelia burgdorferi depend upon the spirochete's ability to modulate its transcriptome as it cycles between its arthropod vector and reservoir host. This complex adaptive process is collectively referred to as "host
The transmission, survival, and virulence of Borrelia burgdorferi depend upon the spirochete's ability to modulate its transcriptome …
OspC-independent infection and dissemination by host-adapted Borrelia burgdorferi.
Tilly K, Bestor A, Dulebohn DP, Rosa PA. Tilly K, et al. Infect Immun. 2009 Jul;77(7):2672-82. doi: 10.1128/IAI.01193-08. Epub 2009 Apr 27. Infect Immun. 2009. PMID: 19398538 Free PMC article.
These experiments demonstrate that mammalian host-adapted spirochetes can infect and disseminate in mice in the absence of OspC, thereby circumventing this hallmark of tick-derived or in vitro-grown spirochetes. ...In this model, another protein uniquely present on …
These experiments demonstrate that mammalian host-adapted spirochetes can infect and disseminate in mice in the absence of Osp …
Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques.
Crossland NA, Alvarez X, Embers ME. Crossland NA, et al. Am J Pathol. 2018 Mar;188(3):672-682. doi: 10.1016/j.ajpath.2017.11.005. Epub 2017 Dec 12. Am J Pathol. 2018. PMID: 29242055 Free PMC article.
Borrelia antigen staining of probable spirochete cross sections was also observed in heart, skeletal muscle, and near peripheral nerves of treated and untreated animals. These findings support the notion that chronic Lyme disease symptoms can be attributable to residual in
Borrelia antigen staining of probable spirochete cross sections was also observed in heart, skeletal muscle, and near peripheral nerv
Host-adapted Borrelia burgdorferi in mice expresses OspA during inflammation.
Crowley H, Huber BT. Crowley H, et al. Infect Immun. 2003 Jul;71(7):4003-10. doi: 10.1128/iai.71.7.4003-4010.2003. Infect Immun. 2003. PMID: 12819088 Free PMC article.
Furthermore, host-adapted B. burgdorferi with a low OspA phenotype upregulates OspA expression when transferred to an inflammatory in vivo environment. The results obtained by these techniques uniformly identify inflammation as a mediator of in vivo OspA expression …
Furthermore, host-adapted B. burgdorferi with a low OspA phenotype upregulates OspA expression when transferred to an inflamma …
Comparison of protection in rabbits against host-adapted and cultivated Borrelia burgdorferi following infection-derived immunity or immunization with outer membrane vesicles or outer surface protein A.
Shang ES, Champion CI, Wu XY, Skare JT, Blanco DR, Miller JN, Lovett MA. Shang ES, et al. Infect Immun. 2000 Jul;68(7):4189-99. doi: 10.1128/iai.68.7.4189-4199.2000. Infect Immun. 2000. PMID: 10858236 Free PMC article.
Protection against host-adapted B. burgdorferi was assessed by implantation of skin biopsies taken from rabbit erythema migrans (a uniquely rich source of B. burgdorferi in vertebrate tissue) containing up to 10(8) spirochetes. ...Analysis of the antibody responses …
Protection against host-adapted B. burgdorferi was assessed by implantation of skin biopsies taken from rabbit erythema migran …
Immune evasion by tickborne and host-adapted Borrelia burgdorferi.
de Silva AM, Fikrig E, Hodzic E, Kantor FS, Telford SR 3rd, Barthold SW. de Silva AM, et al. J Infect Dis. 1998 Feb;177(2):395-400. doi: 10.1086/514200. J Infect Dis. 1998. PMID: 9466527
Immune sera from mice infected with the Lyme disease spirochete, Borrelia burgdorferi, have strong biologic activity against spirochetes cultured in vitro. ...These results indicate that spirochetes that have adapted within either the feeding tick or host are …
Immune sera from mice infected with the Lyme disease spirochete, Borrelia burgdorferi, have strong biologic activity against spiroche …
Homologous and heterologous Borrelia burgdorferi challenge of infection-derived immune rabbits using host-adapted organisms.
Shang ES, Wu XY, Lovett MA, Miller JN, Blanco DR. Shang ES, et al. Infect Immun. 2001 Jan;69(1):593-8. doi: 10.1128/IAI.69.1.593-598.2001. Infect Immun. 2001. PMID: 11119560 Free PMC article.
We have recently found that strain B31 infection-immune rabbits are completely protected against homologous challenge with large numbers (>10(6)) of host-adapted Borrelia burgdorferi (HAB) (E. ...
We have recently found that strain B31 infection-immune rabbits are completely protected against homologous challenge with large numbers (&g …
Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals.
Mulay VB, Caimano MJ, Iyer R, Dunham-Ems S, Liveris D, Petzke MM, Schwartz I, Radolf JD. Mulay VB, et al. J Bacteriol. 2009 Apr;191(8):2783-94. doi: 10.1128/JB.01802-08. Epub 2009 Feb 13. J Bacteriol. 2009. PMID: 19218390 Free PMC article.
Although BBA74 initially was described as a 28-kDa virulence-associated outer-membrane-spanning protein with porin-like function, subsequent studies revealed that it is periplasmic and downregulated in mammalian host-adapted spirochetes. To further elucidate the rol …
Although BBA74 initially was described as a 28-kDa virulence-associated outer-membrane-spanning protein with porin-like function, subsequent …
Adaptation of the Lyme disease spirochaete to the mammalian host environment results in enhanced glycosaminoglycan and host cell binding.
Parveen N, Caimano M, Radolf JD, Leong JM. Parveen N, et al. Mol Microbiol. 2003 Mar;47(5):1433-44. doi: 10.1046/j.1365-2958.2003.03388.x. Mol Microbiol. 2003. PMID: 12603746 Free article.
The Lyme disease spirochaete, Borrelia burgdorferi, is transmitted to mammals by Ixodes ticks and can infect multiple tissues. ...Immunofluorescent staining of in vitro-cultivated or host-adapted spirochaetes revealed that DbpA and DbpB were present on the ba …
The Lyme disease spirochaete, Borrelia burgdorferi, is transmitted to mammals by Ixodes ticks and can infect multiple tissues. ...Imm …
Identification of Surface Epitopes Associated with Protection against Highly Immune-Evasive VlsE-Expressing Lyme Disease Spirochetes.
Batool M, Caoili SEC, Dangott LJ, Gerasimov E, Ionov Y, Piontkivska H, Zelikovsky A, Waghela SD, Rogovskyy AS. Batool M, et al. Infect Immun. 2018 Jul 23;86(8):e00182-18. doi: 10.1128/IAI.00182-18. Print 2018 Aug. Infect Immun. 2018. PMID: 29866906 Free PMC article.
The tick-borne pathogen Borrelia burgdorferi is responsible for approximately 300,000 Lyme disease (LD) cases per year in the United States. ...Toward the identification, we repeatedly immunized immunocompetent mice with live-attenuated VlsE-deleted B. burgdorferi and then …
The tick-borne pathogen Borrelia burgdorferi is responsible for approximately 300,000 Lyme disease (LD) cases per year in the United …
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