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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 2
2001 4
2002 6
2003 10
2004 6
2005 7
2006 9
2007 8
2008 9
2009 11
2010 9
2011 5
2012 6
2013 8
2014 5
2015 6
2016 4
2017 4
2018 5
2019 4
2020 3
2021 5
2022 1
2023 2

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126 results

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Page 1
Immune Dysfunction and Albumin-Related Immunity in Liver Cirrhosis.
Wilde B, Katsounas A. Wilde B, et al. Mediators Inflamm. 2019 Feb 25;2019:7537649. doi: 10.1155/2019/7537649. eCollection 2019. Mediators Inflamm. 2019. PMID: 30930689 Free PMC article. Review.
Bacterial translocation supports-and is supported by-uncontrolled activation of immune cell responses and/or loss of toll-like receptor (TLR) tolerance, which can turn exaggerated inflammatory responses to systemic inflammation. ...To date, there is no data availabl …
Bacterial translocation supports-and is supported by-uncontrolled activation of immune cell responses and/or loss of toll-like recept …
Endotoxin tolerance: is there a clinical relevance?
Cavaillon JM, Adrie C, Fitting C, Adib-Conquy M. Cavaillon JM, et al. J Endotoxin Res. 2003;9(2):101-7. doi: 10.1179/096805103125001487. J Endotoxin Res. 2003. PMID: 12803883 Review.
Beeson (1946) first defined endotoxin tolerance as a reduced endotoxin-induced fever following repeated injections of typhoid vaccine. ...Evans and Zuckerman (1991) reported a role for glucocorticoids in endotoxin tolerance. Prostaglandins, inte …
Beeson (1946) first defined endotoxin tolerance as a reduced endotoxin-induced fever following repeated injections of t …
Molecular mechanisms of endotoxin tolerance.
Fan H, Cook JA. Fan H, et al. J Endotoxin Res. 2004;10(2):71-84. doi: 10.1179/096805104225003997. J Endotoxin Res. 2004. PMID: 15119998 Review.
The phenomenon of endotoxin tolerance has been widely investigated, but to date, the molecular mechanisms of endotoxin tolerance remain to be resolved clearly. ...During tolerance expression of LPS-binding protein (LBP), CD14, myeloid differenti …
The phenomenon of endotoxin tolerance has been widely investigated, but to date, the molecular mechanisms of endotoxin …
Resistance of MMP9 and TIMP1 to endotoxin tolerance.
Muthukuru M, Cutler CW. Muthukuru M, et al. Pathog Dis. 2015 Jul;73(5):ftu003. doi: 10.1093/femspd/ftu003. Epub 2014 Dec 4. Pathog Dis. 2015. PMID: 25951835 Free PMC article.
Interestingly, endotoxin tolerance significantly upregulated TIMP1 relative to MMP9 and downmodulated MMP9 secretion and its enzymatic activity. These results suggest that regulatory mechanisms such as induction of endotoxin tolerance could inhibit MMP …
Interestingly, endotoxin tolerance significantly upregulated TIMP1 relative to MMP9 and downmodulated MMP9 secretion and its e …
Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling.
Murphy MB, Xiong Y, Pattabiraman G, Manavalan TT, Qiu F, Medvedev AE. Murphy MB, et al. J Leukoc Biol. 2015 Dec;98(6):963-74. doi: 10.1189/jlb.2VMA0515-229RR. Epub 2015 Aug 26. J Leukoc Biol. 2015. PMID: 26310831 Free PMC article.
However, endotoxin tolerance renders septic patients immunocompromised and unable to control secondary infections. ...Finally, Pellino-3 ablation in THP-1 decreased the extent of endotoxin tolerization. Thus, Pellino-3 is involved in endotoxin toler …
However, endotoxin tolerance renders septic patients immunocompromised and unable to control secondary infections. ...Finally, …
Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212.
Nahid MA, Yao B, Dominguez-Gutierrez PR, Kesavalu L, Satoh M, Chan EK. Nahid MA, et al. J Immunol. 2013 Feb 1;190(3):1250-63. doi: 10.4049/jimmunol.1103060. Epub 2012 Dec 21. J Immunol. 2013. PMID: 23264652 Free PMC article.
The rapid induction of miR-132/-212 was transcription factor CREB dependent, and the sustained expression of miR-132/-212 was responsible for inducing tolerance to subsequent PGN challenge. Cross-tolerance was observed by TLR5 ligand flagellin and heat-killed or liv …
The rapid induction of miR-132/-212 was transcription factor CREB dependent, and the sustained expression of miR-132/-212 was responsible fo …
Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: distinct alterations in IL-1 receptor-associated kinase.
Jacinto R, Hartung T, McCall C, Li L. Jacinto R, et al. J Immunol. 2002 Jun 15;168(12):6136-41. doi: 10.4049/jimmunol.168.12.6136. J Immunol. 2002. PMID: 12055225
Human Toll-like receptor (TLR) 4 and TLR2 receptors recognize LPS or lipoteichoic acid (LTA), respectively. ...IRAK from LTA-tolerized cells can be subsequently activated and degraded by further LPS challenge, but not LTA treatment. Our studies reveal that LTA-induced t …
Human Toll-like receptor (TLR) 4 and TLR2 receptors recognize LPS or lipoteichoic acid (LTA), respectively. ...IRAK from LTA-tolerize …
Regulation of innate immune responses by Toll-like receptors.
Takeda K, Akira S. Takeda K, et al. Jpn J Infect Dis. 2001 Dec;54(6):209-19. Jpn J Infect Dis. 2001. PMID: 11862002 Review.
Innate immune response in Drosophila is mediated by signaling through Toll receptors. ...In the case of TLR4 signaling, an MyD88-independent pathway is now being characterized. In addition to the activation of innate immune responses, TLR-mediated signaling leads to …
Innate immune response in Drosophila is mediated by signaling through Toll receptors. ...In the case of TLR4 signaling, an MyD88-inde …
Potentiation and tolerance of toll-like receptor priming in human endothelial cells.
Koch SR, Lamb FS, Hellman J, Sherwood ER, Stark RJ. Koch SR, et al. Transl Res. 2017 Feb;180:53-67.e4. doi: 10.1016/j.trsl.2016.08.001. Epub 2016 Aug 8. Transl Res. 2017. PMID: 27567430 Free PMC article.
Specifically with regards to endothelial cells, a key component of innate immunity, the impact of TLR cross-modulation is unknown. We postulated that TLR2 priming (via Pam3Csk4) would inhibit TLR4-mediated responses while TLR3 priming (via Poly I:C) would enhance subsequen …
Specifically with regards to endothelial cells, a key component of innate immunity, the impact of TLR cross-modulation is unknown. We postul …
Endotoxin tolerance and cross-tolerance in mast cells involves TLR4, TLR2 and FcepsilonR1 interactions and SOCS expression: perspectives on immunomodulation in infectious and allergic diseases.
Saturnino SF, Prado RO, Cunha-Melo JR, Andrade MV. Saturnino SF, et al. BMC Infect Dis. 2010 Aug 14;10:240. doi: 10.1186/1471-2334-10-240. BMC Infect Dis. 2010. PMID: 20707930 Free PMC article.
Here we evaluated the phenomenon of direct tolerance of endotoxins, as well as the induction of cross-tolerance and synergism by stimulation with toll-like receptor-2 (TLR2) and FcepsilonR1 agonists, in murine mast cells prestimulated with lipopolysacc …
Here we evaluated the phenomenon of direct tolerance of endotoxins, as well as the induction of cross-tolerance and syn …
126 results