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Table representation of search results timeline featuring number of search results per year.

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1999 1
2000 2
2001 4
2002 6
2003 10
2004 6
2005 7
2006 9
2007 8
2008 9
2009 11
2010 9
2011 5
2012 6
2013 8
2014 5
2015 6
2016 4
2017 4
2018 5
2019 1
2020 0
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115 results
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Page 1
Immune Dysfunction and Albumin-Related Immunity in Liver Cirrhosis.
Wilde B, Katsounas A. Wilde B, et al. Mediators Inflamm. 2019 Feb 25;2019:7537649. doi: 10.1155/2019/7537649. eCollection 2019. Mediators Inflamm. 2019. PMID: 30930689 Free PMC article. Review.
Bacterial translocation supports-and is supported by-uncontrolled activation of immune cell responses and/or loss of toll-like receptor (TLR) tolerance, which can turn exaggerated inflammatory responses to systemic inflammation. Lipopolysaccharide (LPS) or endoto
Bacterial translocation supports-and is supported by-uncontrolled activation of immune cell responses and/or loss of toll-like recept …
Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages.
Butcher SK, O'Carroll CE, Wells CA, Carmody RJ. Butcher SK, et al. Front Immunol. 2018 May 14;9:933. doi: 10.3389/fimmu.2018.00933. eCollection 2018. Front Immunol. 2018. PMID: 29867935 Free PMC article.
Tolerance is a long-recognized property of macrophages that leads to an altered response to repeated or chronic exposure to endotoxin. ...These data provide a basis for the future exploitation of TLR-specific tolerant states to achieve therapeutic re-programming of
Tolerance is a long-recognized property of macrophages that leads to an altered response to repeated or chronic exposure to endoto
miR-146a regulates the crosstalk between intestinal epithelial cells, microbial components and inflammatory stimuli.
Anzola A, González R, Gámez-Belmonte R, Ocón B, Aranda CJ, Martínez-Moya P, López-Posadas R, Hernández-Chirlaque C, Sánchez de Medina F, Martínez-Augustin O. Anzola A, et al. Sci Rep. 2018 Nov 26;8(1):17350. doi: 10.1038/s41598-018-35338-y. Sci Rep. 2018. PMID: 30478292 Free PMC article.
Accordingly, the induction of miR-146a is lower in TLR4, but not in TLR2 knock out mice in both basal and colitic conditions. miR-146a overexpression in IECs induces immune tolerance, inhibiting cytokine production (MCP-1 and GROα/IL-8) in response to LPS (IE …
Accordingly, the induction of miR-146a is lower in TLR4, but not in TLR2 knock out mice in both basal and colitic conditions. miR-146 …
The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages.
Lea SR, Reynolds SL, Kaur M, Simpson KD, Hall SR, Hessel EM, Singh D. Lea SR, et al. Int J Chron Obstruct Pulmon Dis. 2018 Mar 2;13:771-780. doi: 10.2147/COPD.S97071. eCollection 2018. Int J Chron Obstruct Pulmon Dis. 2018. PMID: 29535517 Free PMC article.
We have studied the response of COPD alveolar macrophages to repetitive stimulation with TLR2 and TLR4 ligands. We investigated the effect of sequential stimulation with different ligands to determine whether this results in tolerance or amplification of the immu
We have studied the response of COPD alveolar macrophages to repetitive stimulation with TLR2 and TLR4 ligands. We investigated the e …
Myeloid-related protein 8 induces self-tolerance and cross-tolerance to bacterial infection via TLR4- and TLR2-mediated signal pathways.
Coveney AP, Wang W, Kelly J, Liu JH, Blankson S, Wu QD, Redmond HP, Wang JH. Coveney AP, et al. Sci Rep. 2015 Sep 2;5:13694. doi: 10.1038/srep13694. Sci Rep. 2015. PMID: 26329314 Free PMC article.
However, it is unclear whether Mrp8 could induce self-tolerance and cross-tolerance to bacterial infection. Here we report that Mrp8 triggered TNF-α and IL-6 release via a Toll-like receptor 4 (TLR4)-dependent manner. ...In addition to TLR4, TLR2 also contrib …
However, it is unclear whether Mrp8 could induce self-tolerance and cross-tolerance to bacterial infection. Here we report tha …
Neuroinflammation triggered by β-glucan/dectin-1 signaling enables CNS axon regeneration.
Baldwin KT, Carbajal KS, Segal BM, Giger RJ. Baldwin KT, et al. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2581-6. doi: 10.1073/pnas.1423221112. Epub 2015 Feb 9. Proc Natl Acad Sci U S A. 2015. PMID: 25675510 Free PMC article.
In mice deficient for the pattern recognition receptor dectin-1 but not Toll-like receptor-2 (TLR2), zymosan-mediated RGC regeneration is greatly reduced. ...Studies with dectin-1(-/-)/WT reciprocal bone marrow chimeric mice revealed a requirement for dectin-1 in both reti …
In mice deficient for the pattern recognition receptor dectin-1 but not Toll-like receptor-2 (TLR2), zymosan-mediated RGC regeneratio …
Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212.
Nahid MA, Yao B, Dominguez-Gutierrez PR, Kesavalu L, Satoh M, Chan EK. Nahid MA, et al. J Immunol. 2013 Feb 1;190(3):1250-63. doi: 10.4049/jimmunol.1103060. Epub 2012 Dec 21. J Immunol. 2013. PMID: 23264652 Free PMC article.
Innate immune response is the first defense against pathogens via recognition by various conserved pattern recognition receptors, such as TLRs, to initiate a rapid and strong cytokine alarm. ...Transfection of miR-132 or miR-212 alone mimicked PGN tolerance in monoc …
Innate immune response is the first defense against pathogens via recognition by various conserved pattern recognition receptors, suc …
Resistance of MMP9 and TIMP1 to endotoxin tolerance.
Muthukuru M, Cutler CW. Muthukuru M, et al. Pathog Dis. 2015 Jul;73(5):ftu003. doi: 10.1093/femspd/ftu003. Epub 2014 Dec 4. Pathog Dis. 2015. PMID: 25951835 Free PMC article.
However, little is known about how downregulation of inflammatory cytokines during endotoxin tolerance regulates MMP activities. ...Interestingly, endotoxin tolerance significantly upregulated TIMP1 relative to MMP9 and downmodulated MMP9 secretion and …
However, little is known about how downregulation of inflammatory cytokines during endotoxin tolerance regulates MMP activitie …
Human periodontal ligament cells exhibit no endotoxin tolerance upon stimulation with Porphyromonas gingivalis lipopolysaccharide.
Blufstein A, Behm C, Nguyen PQ, Rausch-Fan X, Andrukhov O. Blufstein A, et al. J Periodontal Res. 2018 Aug;53(4):589-597. doi: 10.1111/jre.12549. Epub 2018 Mar 26. J Periodontal Res. 2018. PMID: 29582430 Free PMC article.
BACKGROUND/OBJECTIVES: Endotoxin tolerance is characterized by a state of hyporesponsiveness after confrontation with endotoxins such as lipopolysaccharides (LPS) at low concentrations. ...In some cases, pretreated cells exhibited lower gene expression levels …
BACKGROUND/OBJECTIVES: Endotoxin tolerance is characterized by a state of hyporesponsiveness after confrontation with endot
Endotoxin tolerance induced by lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coli: alternations in Toll-like receptor 2 and 4 signaling pathway.
Sun Y, Li H, Sun MJ, Zheng YY, Gong DJ, Xu Y. Sun Y, et al. Inflammation. 2014 Feb;37(1):268-76. doi: 10.1007/s10753-013-9737-5. Inflammation. 2014. PMID: 24132662
Exposure of the host to periodontal pathogens and their virulence factors induces a hyporesponsive state to subsequent challenge, which is termed endotoxin tolerance. ...Moreover, TLR2, TLR4, IRAK-M, and SOCS1 might play important roles in developing toler
Exposure of the host to periodontal pathogens and their virulence factors induces a hyporesponsive state to subsequent challenge, which is t …
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