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EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins.
Fitzsimmons L, Cartlidge R, Chang C, Sejic N, Galbraith LCA, Suraweera CD, Croom-Carter D, Dewson G, Tierney RJ, Bell AI, Shannon-Lowe C, Herold MJ, Rickinson AB, Colman PM, Huang DCS, Strasser A, Kvansakul M, Rowe M, Kelly GL. Fitzsimmons L, et al. Cell Death Differ. 2020 May;27(5):1554-1568. doi: 10.1038/s41418-019-0435-1. Epub 2019 Oct 23. Cell Death Differ. 2020. PMID: 31645677 Free PMC article.
Like many infectious agents, EBV has evolved strategies to block host cell death, including through expression of viral homologues of cellular BCL-2 pro-survival proteins (vBCL-2s), such as BHRF1. ...BHRF1 interacts with the cellular pro-apoptot …
Like many infectious agents, EBV has evolved strategies to block host cell death, including through expression of viral homologues of …
Designing BH3-Mimetic Peptide Inhibitors for the Viral Bcl-2 Homologues A179L and BHRF1: Importance of Long-Range Electrostatic Interactions.
Reddy CN, Sankararamakrishnan R. Reddy CN, et al. ACS Omega. 2021 Oct 4;6(41):26976-26989. doi: 10.1021/acsomega.1c03385. eCollection 2021 Oct 19. ACS Omega. 2021. PMID: 34693118 Free PMC article.
Hence, vBcl-2 homologues are attractive targets to prevent viral infection. However, very few studies have focused on developing inhibitors for vBcl-2 homologues. In this study, we have considered two vBcl-2 homologues, A179L from African …
Hence, vBcl-2 homologues are attractive targets to prevent viral infection. However, very few studies have focused on developi …
Rheumatic disease patients, prone to Sjögren's syndrome and/or lymphoma, mount an antibody response to BHRF1, the Epstein-Barr viral homologue of BCL-2.
Newkirk MM, Shiroky JB, Johnson N, Danoff D, Isenberg DA, Shustik C, Pearson GR. Newkirk MM, et al. Br J Rheumatol. 1996 Nov;35(11):1075-81. doi: 10.1093/rheumatology/35.11.1075. Br J Rheumatol. 1996. PMID: 8948292
The IgG response to Epstein-Barr virus (EBV) early antigens [BHRF1 (p 17.1), the viral homologue of bcl-2, and BMRF1 (p50.10), a DNA binding protein] was measured in patients with rheumatic disease to see whether there was any association with lymphoma …
The IgG response to Epstein-Barr virus (EBV) early antigens [BHRF1 (p 17.1), the viral homologue of bcl-2, and B …
Polymorphisms of Epstein-Barr virus BHRF1 gene, a homologue of bcl-2.
Jing YZ, Wang Y, Jia YP, Luo B. Jing YZ, et al. Chin J Cancer. 2010 Dec;29(12):1000-5. doi: 10.5732/cjc.010.10241. Chin J Cancer. 2010. PMID: 21114920 Free article.
The corresponding regions of bcl-2 homologues were conserved in all isolates except for 3 samples. ...CONCLUSIONS: The 79V88V is the dominant variant in NPC, EBVaGC, and TW samples from healthy donors and preferential linkages between BHRF1 and EBNA3C …
The corresponding regions of bcl-2 homologues were conserved in all isolates except for 3 samples. ...CONCLUSIONS: The …
BHRF1, a viral homologue of the Bcl-2 oncogene, is conserved at both the sequence and functional level in different Epstein-Barr virus isolates.
Khanim F, Dawson C, Meseda CA, Dawson J, Mackett M, Young LS. Khanim F, et al. J Gen Virol. 1997 Nov;78 ( Pt 11):2987-99. doi: 10.1099/0022-1317-78-11-2987. J Gen Virol. 1997. PMID: 9367386
A small number of base changes which resulted in amino acid substitutions in the BHRF1 protein were found relative to the prototype B95.8 EBV sequence and these were predominantly clustered near the amino terminus of the BHRF1 protein outside conserved domains ident …
A small number of base changes which resulted in amino acid substitutions in the BHRF1 protein were found relative to the prototype B …
Herpesvirus pan encodes a functional homologue of BHRF1, the Epstein-Barr virus v-Bcl-2.
Howell M, Williams T, Hazlewood SA. Howell M, et al. BMC Microbiol. 2005 Feb 3;5:6. doi: 10.1186/1471-2180-5-6. BMC Microbiol. 2005. PMID: 15691372 Free PMC article.
BACKGROUND: Epstein-Barr virus (EBV) latently infects about 90% of the human population and is associated with benign and malignant diseases of lymphoid and epithelial origin. BHRF1, an early lytic cycle antigen, is an apoptosis suppressing member of the Bcl-2 …
BACKGROUND: Epstein-Barr virus (EBV) latently infects about 90% of the human population and is associated with benign and malignant diseases …
Mitochondria as functional targets of proteins coded by human tumor viruses.
D'Agostino DM, Bernardi P, Chieco-Bianchi L, Ciminale V. D'Agostino DM, et al. Adv Cancer Res. 2005;94:87-142. doi: 10.1016/S0065-230X(05)94003-7. Adv Cancer Res. 2005. PMID: 16096000 Review.
The list of these viral proteins includes BCL-2 homologues (BHRF1 of EBV; KSBCL-2 of KSHV), an inhibitor of apoptosis (IAP) resembling Survivin (KSHV K7), proteins that alter mitochondrial ion permeability and/or membrane potential (HBV HBx, HPV …
The list of these viral proteins includes BCL-2 homologues (BHRF1 of EBV; KSBCL-2 of KSHV), an inhibitor …
Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival.
Li LY, Liu MY, Shih HM, Tsai CH, Chen JY. Li LY, et al. J Gen Virol. 2006 Oct;87(Pt 10):2869-2878. doi: 10.1099/vir.0.81953-0. J Gen Virol. 2006. PMID: 16963744
BHRF1, an early gene product of Epstein-Barr virus (EBV), is structurally and functionally homologous to Bcl-2, a cellular anti-apoptotic protein. ...Analyses of VRK2-deletion mutants revealed that a 108 aa fragment at the C terminus was important for VRK2 to …
BHRF1, an early gene product of Epstein-Barr virus (EBV), is structurally and functionally homologous to Bcl-2, a cellu …
Functional differences between BHRF1, the Epstein-Barr virus-encoded Bcl-2 homologue, and Bcl-2 in human epithelial cells.
Dawson CW, Dawson J, Jones R, Ward K, Young LS. Dawson CW, et al. J Virol. 1998 Nov;72(11):9016-24. doi: 10.1128/JVI.72.11.9016-9024.1998. J Virol. 1998. PMID: 9765446 Free PMC article.
While both BHRF1 and Bcl-2 inhibited epithelial differentiation, the effect of Bcl-2 was more pronounced, resulting in an almost complete blockade of differentiation in organotypic raft cultures. However, BHRF1-expressing SCC12F cells pro …
While both BHRF1 and Bcl-2 inhibited epithelial differentiation, the effect of Bcl-2 was more pronounced, …
Contrasting roles for G-quadruplexes in regulating human Bcl-2 and virus homologues KSHV KS-Bcl-2 and EBV BHRF1.
Kumar S, Ramamurthy C, Choudhary D, Sekar A, Patra A, Bhavesh NS, Vivekanandan P. Kumar S, et al. Sci Rep. 2022 Mar 23;12(1):5019. doi: 10.1038/s41598-022-08161-9. Sci Rep. 2022. PMID: 35322051 Free PMC article.
We sought to understand the role of G-quadruplexes in the regulatory regions of viral Bcl-2 homologues encoded by KSHV (KS-Bcl-2) and EBV (BHRF1). We demonstrate that the KSHV KS-Bcl-2 and the EBV BHRF1 promoter G-qua …
We sought to understand the role of G-quadruplexes in the regulatory regions of viral Bcl-2 homologues encoded by KSHV …
39 results