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Year Number of Results
1988 2
1989 1
1991 1
1992 3
1993 3
1994 2
1995 2
1996 4
1997 1
1998 3
1999 5
2000 6
2001 5
2002 9
2003 13
2004 10
2005 11
2006 10
2007 13
2008 15
2009 10
2010 9
2011 16
2012 18
2013 17
2014 9
2015 11
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2017 18
2018 7
2019 6
2020 1
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234 results
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USP13 negatively regulates antiviral responses by deubiquitinating STING.
Sun H, Zhang Q, Jing YY, Zhang M, Wang HY, Cai Z, Liuyu T, Zhang ZD, Xiong TC, Wu Y, Zhu QY, Yao J, Shu HB, Lin D, Zhong B. Sun H, et al. Nat Commun. 2017 May 23;8:15534. doi: 10.1038/ncomms15534. Nat Commun. 2017. PMID: 28534493 Free PMC article.
Knockdown or knockout of USP13 potentiates activation of IRF3 and NF-κB and expression of downstream genes after HSV-1 infection or transfection of DNA ligands. ...
Knockdown or knockout of USP13 potentiates activation of IRF3 and NF-κB and expression of downstream genes after HSV-1 infection or t …
Anti-Infectivity against Herpes Simplex Virus and Selected Microbes and Anti-Inflammatory Activities of Compounds Isolated from Eucalyptus globulus Labill.
Brezáni V, Leláková V, Hassan STS, Berchová-Bímová K, Nový P, Klouček P, Maršík P, Dall'Acqua S, Hošek J, Šmejkal K. Brezáni V, et al. Viruses. 2018 Jul 6;10(7):360. doi: 10.3390/v10070360. Viruses. 2018. PMID: 29986399 Free PMC article.
Herpes simplex virus (HSV) causes numerous mild-to-serious human diseases, including mucocutaneous herpes infections and life-threatening herpes encephalitis. ...The anti-inflammatory potential was examined using LPS-stimulated THP-1-XBlue™-MD2-CD14 and THP-1
Herpes simplex virus (HSV) causes numerous mild-to-serious human diseases, including mucocutaneous herpes infections and life-
USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling.
Cai J, Chen HY, Peng SJ, Meng JL, Wang Y, Zhou Y, Qian XP, Sun XY, Pang XW, Zhang Y, Zhang J. Cai J, et al. FASEB J. 2018 Oct;32(10):5238-5249. doi: 10.1096/fj.201700473RR. Epub 2018 Apr 24. FASEB J. 2018. PMID: 29688809
In this study, we identified a deubiquitinase, the ubiquitin-specific peptidase 7/herpes virus associated ubiquitin-specific protease (USP7/HAUSP) as an important negative modulator of virus-induced signaling. ...In addition, TNF receptor-associated factor family member-as …
In this study, we identified a deubiquitinase, the ubiquitin-specific peptidase 7/herpes virus associated ubiquitin-specific protease …
Boswellia serrata oleo-gum-resin and β-boswellic acid inhibits HSV-1 infection in vitro through modulation of NF-кB and p38 MAP kinase signaling.
Goswami D, Mahapatra AD, Banerjee S, Kar A, Ojha D, Mukherjee PK, Chattopadhyay D. Goswami D, et al. Phytomedicine. 2018 Dec 1;51:94-103. doi: 10.1016/j.phymed.2018.10.016. Epub 2018 Oct 16. Phytomedicine. 2018. PMID: 30466633
BACKGROUND: Herpes Simplex Virus (HSV), a highly contagious pathogen, is responsible for causing lifelong oral to genital infection in human. ...Based on target analysis we examined the inhibition of NF-κB, essential for virus replication, and observed significant d …
BACKGROUND: Herpes Simplex Virus (HSV), a highly contagious pathogen, is responsible for causing lifelong oral to genital infection i …
STAT3/NF-κB-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer.
Kuo WY, Hwu L, Wu CY, Lee JS, Chang CW, Liu RS. Kuo WY, et al. Theranostics. 2017 Jan 15;7(3):647-663. doi: 10.7150/thno.16827. eCollection 2017. Theranostics. 2017. PMID: 28255357 Free PMC article.
In this study, we have cloned a novel STAT3/NF-κB-based reporter system to drive the expression of herpes simplex virus thymidine kinase (HSV-TK) against breast cancer. ...The Lenti-CMV-TK showed ~5 fold higher (3)H-FEAU uptake then Lenti -STAT3-NF-κB-TK. In …
In this study, we have cloned a novel STAT3/NF-κB-based reporter system to drive the expression of herpes simplex virus thymid …
USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.
Zhang M, Zhang MX, Zhang Q, Zhu GF, Yuan L, Zhang DE, Zhu Q, Yao J, Shu HB, Zhong B. Zhang M, et al. Cell Res. 2016 Dec;26(12):1302-1319. doi: 10.1038/cr.2016.125. Epub 2016 Nov 1. Cell Res. 2016. PMID: 27801882 Free PMC article.
USP18 deficiency or knockdown of USP20 resulted in enhanced K48-linked ubiquitination and accelerated degradation of STING, and impaired activation of IRF3 and NF-κB as well as induction of downstream genes after infection with DNA virus HSV-1 or transfection of various DN …
USP18 deficiency or knockdown of USP20 resulted in enhanced K48-linked ubiquitination and accelerated degradation of STING, and impaired act …
NF-κB-Dependent Production of ROS and Restriction of HSV-1 Infection in U937 Monocytic Cells.
Marino-Merlo F, Papaianni E, Frezza C, Pedatella S, De Nisco M, Macchi B, Grelli S, Mastino A. Marino-Merlo F, et al. Viruses. 2019 May 10;11(5):428. doi: 10.3390/v11050428. Viruses. 2019. PMID: 31083280 Free PMC article.
Herpes simplex virus 1 (HSV-1) can infect a wide range of cell types, including cells of the adaptive and innate immunity but, normally, it completes a fully-permissive replication cycle only in epithelial or neural cells. ...We have recently demonstrated that the transcri
Herpes simplex virus 1 (HSV-1) can infect a wide range of cell types, including cells of the adaptive and innate immunity but, normal
RIG-I-Mediated STING Upregulation Restricts Herpes Simplex Virus 1 Infection.
Liu Y, Goulet ML, Sze A, Hadj SB, Belgnaoui SM, Lababidi RR, Zheng C, Fritz JH, Olagnier D, Lin R. Liu Y, et al. J Virol. 2016 Sep 29;90(20):9406-19. doi: 10.1128/JVI.00748-16. Print 2016 Oct 15. J Virol. 2016. PMID: 27512060 Free PMC article.
Physiologically, this cross talk between the RNA- and DNA-sensing pathways allowed 5'pppRNA to efficiently block infection by herpes simplex virus 1 (HSV-1) both in vitro and in vivo in a STING-dependent fashion. These observations demonstrate that STING induction by RIG-I …
Physiologically, this cross talk between the RNA- and DNA-sensing pathways allowed 5'pppRNA to efficiently block infection by herpes
Assessment of a new arbidol derivative against herpes simplex virus II in human cervical epithelial cells and in BALB/c mice.
Ma N, Shen M, Chen T, Liu Y, Mao Y, Chen L, Xiong H, Hou W, Liu D, Yang Z. Ma N, et al. Biomed Pharmacother. 2019 Oct;118:109359. doi: 10.1016/j.biopha.2019.109359. Epub 2019 Aug 28. Biomed Pharmacother. 2019. PMID: 31545243 Free article.
As one of the highly contagious forms, herpes simplex virus type 2 (HSV-2) commonly caused severe genital diseases and closely referred to the HIV infection. ...The ARD-mediated HSV-2 inhibition was partially attained by blocking NF-κB pathways and down-regulating t …
As one of the highly contagious forms, herpes simplex virus type 2 (HSV-2) commonly caused severe genital diseases and closely referr …
Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1.
Abe T, Barber GN. Abe T, et al. J Virol. 2014 May;88(10):5328-41. doi: 10.1128/JVI.00037-14. Epub 2014 Mar 5. J Virol. 2014. PMID: 24600004 Free PMC article.
STING (stimulator of interferon genes) is known to control the induction of innate immune genes in response to the recognition of cytosolic DNA species, including the genomes of viruses such as herpes simplex virus 1 (HSV-1). ...Thus, our results establish TBK1 as a downst …
STING (stimulator of interferon genes) is known to control the induction of innate immune genes in response to the recognition of cytosolic …
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