TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections.
Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2100225118. doi: 10.1073/pnas.2100225118.
Proc Natl Acad Sci U S A. 2021.
PMID: 33785602
Free PMC article.
However, STING activation can also trigger other downstream pathways such as nuclear factor kappaB (NF-kappaB) signaling and autophagy, and the roles of interferon (IFN)-independent functions of STING in infectious diseases or cancer are not well understood. Here, we gener …
However, STING activation can also trigger other downstream pathways such as nuclear factor kappaB (NF-kappaB) signaling and autophag …