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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 2
1989 1
1991 1
1992 3
1993 3
1994 2
1995 2
1996 4
1997 1
1998 3
1999 5
2000 6
2001 5
2002 9
2003 13
2004 10
2005 11
2006 10
2007 13
2008 15
2009 10
2010 9
2011 16
2012 19
2013 17
2014 9
2015 11
2016 15
2017 18
2018 7
2019 8
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2021 8
2022 10
2023 5

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261 results

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Page 1
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections.
Yum S, Li M, Fang Y, Chen ZJ. Yum S, et al. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2100225118. doi: 10.1073/pnas.2100225118. Proc Natl Acad Sci U S A. 2021. PMID: 33785602 Free PMC article.
However, STING activation can also trigger other downstream pathways such as nuclear factor kappaB (NF-kappaB) signaling and autophagy, and the roles of interferon (IFN)-independent functions of STING in infectious diseases or cancer are not well understood. Here, we gener …
However, STING activation can also trigger other downstream pathways such as nuclear factor kappaB (NF-kappaB) signaling and autophag …
USP13 negatively regulates antiviral responses by deubiquitinating STING.
Sun H, Zhang Q, Jing YY, Zhang M, Wang HY, Cai Z, Liuyu T, Zhang ZD, Xiong TC, Wu Y, Zhu QY, Yao J, Shu HB, Lin D, Zhong B. Sun H, et al. Nat Commun. 2017 May 23;8:15534. doi: 10.1038/ncomms15534. Nat Commun. 2017. PMID: 28534493 Free PMC article.
Knockdown or knockout of USP13 potentiates activation of IRF3 and NF-kappaB and expression of downstream genes after HSV-1 infection or transfection of DNA ligands. ...
Knockdown or knockout of USP13 potentiates activation of IRF3 and NF-kappaB and expression of downstream genes after HSV-1 infection …
STAT3/NF-κB-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer.
Kuo WY, Hwu L, Wu CY, Lee JS, Chang CW, Liu RS. Kuo WY, et al. Theranostics. 2017 Jan 15;7(3):647-663. doi: 10.7150/thno.16827. eCollection 2017. Theranostics. 2017. PMID: 28255357 Free PMC article.
In this study, we have cloned a novel STAT3/NF-kappaB-based reporter system to drive the expression of herpes simplex virus thymidine kinase (HSV-TK) against breast cancer. ...The Lenti-CMV-TK showed ~5 fold higher (3)H-FEAU uptake then Lenti -STAT3-NF-kappaB …
In this study, we have cloned a novel STAT3/NF-kappaB-based reporter system to drive the expression of herpes simplex virus th …
USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.
Zhang M, Zhang MX, Zhang Q, Zhu GF, Yuan L, Zhang DE, Zhu Q, Yao J, Shu HB, Zhong B. Zhang M, et al. Cell Res. 2016 Dec;26(12):1302-1319. doi: 10.1038/cr.2016.125. Epub 2016 Nov 1. Cell Res. 2016. PMID: 27801882 Free PMC article.
USP18 deficiency or knockdown of USP20 resulted in enhanced K48-linked ubiquitination and accelerated degradation of STING, and impaired activation of IRF3 and NF-kappaB as well as induction of downstream genes after infection with DNA virus HSV-1 or transfection of variou …
USP18 deficiency or knockdown of USP20 resulted in enhanced K48-linked ubiquitination and accelerated degradation of STING, and impaired act …
Transcription Factor NF-κB: An Update on Intervention Strategies.
Panday A, Inda ME, Bagam P, Sahoo MK, Osorio D, Batra S. Panday A, et al. Arch Immunol Ther Exp (Warsz). 2016 Dec;64(6):463-483. doi: 10.1007/s00005-016-0405-y. Epub 2016 May 28. Arch Immunol Ther Exp (Warsz). 2016. PMID: 27236331 Review.
The chronic activation or dysregulation of NF-kappaB signaling is the central cause of pathogenesis in many disease conditions and, therefore, NF-kappaB is a major focus of therapeutic intervention. ...In this review, we provide an updated synopsis of the role of …
The chronic activation or dysregulation of NF-kappaB signaling is the central cause of pathogenesis in many disease conditions and, t …
Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases.
Bustamante J, Boisson-Dupuis S, Jouanguy E, Picard C, Puel A, Abel L, Casanova JL. Bustamante J, et al. Curr Opin Immunol. 2008 Feb;20(1):39-48. doi: 10.1016/j.coi.2007.10.005. Curr Opin Immunol. 2008. PMID: 18083507 Review.
Human primary immunodeficiencies impairing myeloid and/or lymphoid cellular responses to activating receptors other than antigen receptors have recently been described in children with various infectious diseases. Germline mutations in NEMO and IKBA impair NF-kappaB-mediat …
Human primary immunodeficiencies impairing myeloid and/or lymphoid cellular responses to activating receptors other than antigen receptors h …
Several Alphaherpesviruses Interact Similarly with the NF-κB Pathway and Suppress NF-κB-Dependent Gene Expression.
Romero N, Tishchenko A, Verhamme R, Wuerzberger-Davis SM, Van Waesberghe C, Nauwynck HJ, Miyamoto S, Favoreel HW. Romero N, et al. Microbiol Spectr. 2023 Aug 17;11(4):e0142123. doi: 10.1128/spectrum.01421-23. Epub 2023 Jul 19. Microbiol Spectr. 2023. PMID: 37466427 Free PMC article.
Here, we report that infection of epithelial cells with several alphaherpesviruses of different species, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), feline alphaherpesvirus 1 (FHV-1), and bovine alphaherpesvirus 1 (BoHV-1) results in the inactivation of the r …
Here, we report that infection of epithelial cells with several alphaherpesviruses of different species, including herpes simplex vir …
Herpes simplex type 1 induction of persistent NF-kappa B nuclear translocation increases the efficiency of virus replication.
Patel A, Hanson J, McLean TI, Olgiate J, Hilton M, Miller WE, Bachenheimer SL. Patel A, et al. Virology. 1998 Aug 1;247(2):212-22. doi: 10.1006/viro.1998.9243. Virology. 1998. PMID: 9705914 Free article.
The latent form of the dimeric transcription factor NF-kappa B is sequestered in the cytoplasm by proteins containing ankyrin repeats, such as 1 kappa B alpha and beta, or by the p105 precursor form of the NF-kappa B p50 sub …
The latent form of the dimeric transcription factor NF-kappa B is sequestered in the cytoplasm by proteins containing a …
Nuclear Factor-κB: central regulator in ocular surface inflammation and diseases.
Lan W, Petznick A, Heryati S, Rifada M, Tong L. Lan W, et al. Ocul Surf. 2012 Jul;10(3):137-48. doi: 10.1016/j.jtos.2012.04.001. Epub 2012 Apr 30. Ocul Surf. 2012. PMID: 22814642 Review.
The purpose this article is to summarize key findings with regard to the pathways regulating NF-kappaB and processes governed by the NF-kappaB pathway. In the innate defense system, NF-kappaB is involved in signaling from the toll-like receptors 2, 3, 4, 5 an …
The purpose this article is to summarize key findings with regard to the pathways regulating NF-kappaB and processes governed by the …
Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1 beta-converting enzyme inhibitory protein (vFLIP).
Matta H, Chaudhary PM. Matta H, et al. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9399-404. doi: 10.1073/pnas.0308016101. Epub 2004 Jun 9. Proc Natl Acad Sci U S A. 2004. PMID: 15190178 Free PMC article.
We report that PEL cell lines have constitutive active alternative NF-kappa B pathway and demonstrate high-level expression of NF-kappa B2/p100 precursor and its processed subunit p52. ...K13-induced up-regulation and processing of p100 critical …
We report that PEL cell lines have constitutive active alternative NF-kappa B pathway and demonstrate high-level expres …
261 results