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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 2
1989 1
1991 1
1992 3
1993 3
1994 2
1995 2
1996 4
1997 1
1998 3
1999 5
2000 6
2001 5
2002 9
2003 13
2004 10
2005 11
2006 10
2007 13
2008 15
2009 10
2010 9
2011 16
2012 19
2013 17
2014 9
2015 11
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2018 7
2019 8
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2021 8
2022 4
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251 results
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TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections.
Yum S, Li M, Fang Y, Chen ZJ. Yum S, et al. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2100225118. doi: 10.1073/pnas.2100225118. Proc Natl Acad Sci U S A. 2021. PMID: 33785602 Free PMC article.
However, STING activation can also trigger other downstream pathways such as nuclear factor kappaB (NF-kappaB) signaling and autophagy, and the roles of interferon (IFN)-independent functions of STING in infectious diseases or cancer are not well understood. Here, we gener …
However, STING activation can also trigger other downstream pathways such as nuclear factor kappaB (NF-kappaB) signaling and autophag …
USP13 negatively regulates antiviral responses by deubiquitinating STING.
Sun H, Zhang Q, Jing YY, Zhang M, Wang HY, Cai Z, Liuyu T, Zhang ZD, Xiong TC, Wu Y, Zhu QY, Yao J, Shu HB, Lin D, Zhong B. Sun H, et al. Nat Commun. 2017 May 23;8:15534. doi: 10.1038/ncomms15534. Nat Commun. 2017. PMID: 28534493 Free PMC article.
Knockdown or knockout of USP13 potentiates activation of IRF3 and NF-kappaB and expression of downstream genes after HSV-1 infection or transfection of DNA ligands. ...
Knockdown or knockout of USP13 potentiates activation of IRF3 and NF-kappaB and expression of downstream genes after HSV-1 infection …
USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.
Zhang M, Zhang MX, Zhang Q, Zhu GF, Yuan L, Zhang DE, Zhu Q, Yao J, Shu HB, Zhong B. Zhang M, et al. Cell Res. 2016 Dec;26(12):1302-1319. doi: 10.1038/cr.2016.125. Epub 2016 Nov 1. Cell Res. 2016. PMID: 27801882 Free PMC article.
USP18 deficiency or knockdown of USP20 resulted in enhanced K48-linked ubiquitination and accelerated degradation of STING, and impaired activation of IRF3 and NF-kappaB as well as induction of downstream genes after infection with DNA virus HSV-1 or transfection of variou …
USP18 deficiency or knockdown of USP20 resulted in enhanced K48-linked ubiquitination and accelerated degradation of STING, and impaired act …
STAT3/NF-κB-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer.
Kuo WY, Hwu L, Wu CY, Lee JS, Chang CW, Liu RS. Kuo WY, et al. Theranostics. 2017 Jan 15;7(3):647-663. doi: 10.7150/thno.16827. eCollection 2017. Theranostics. 2017. PMID: 28255357 Free PMC article.
In this study, we have cloned a novel STAT3/NF-kappaB-based reporter system to drive the expression of herpes simplex virus thymidine kinase (HSV-TK) against breast cancer. ...The Lenti-CMV-TK showed ~5 fold higher (3)H-FEAU uptake then Lenti -STAT3-NF-kappaB …
In this study, we have cloned a novel STAT3/NF-kappaB-based reporter system to drive the expression of herpes simplex virus th …
Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1.
Abe T, Barber GN. Abe T, et al. J Virol. 2014 May;88(10):5328-41. doi: 10.1128/JVI.00037-14. Epub 2014 Mar 5. J Virol. 2014. PMID: 24600004 Free PMC article.
The triggering of NF-kappaB function was noted to require TRAF6 activation. Our findings detail a novel dsDNA-mediated NF-kappaB activation pathway facilitated through a STING-TRAF6-TBK1 axis and suggest a target for therapeutic intervention to plausibly stimulate a …
The triggering of NF-kappaB function was noted to require TRAF6 activation. Our findings detail a novel dsDNA-mediated NF-kapp …
Herpes Simplex Virus Type 2 Glycoprotein D Inhibits NF-κB Activation by Interacting with p65.
Li C, Zhang M, Guan X, Hu H, Fu M, Liu Y, Hu Q. Li C, et al. J Immunol. 2021 Jun 15;206(12):2852-2861. doi: 10.4049/jimmunol.2001336. Epub 2021 May 28. J Immunol. 2021. PMID: 34049972
NF-kappaB plays a crucial role in regulating cell proliferation, inflammation, apoptosis, and immune responses. ...Mechanistically, HSV-2 gD inhibited NF-kappaB, but not IFN-regulatory factor 3 (IRF3), activation and suppressed NF-kappaB activation mediated b
NF-kappaB plays a crucial role in regulating cell proliferation, inflammation, apoptosis, and immune responses. ...Mechanistically, H
Transcription Factor NF-κB: An Update on Intervention Strategies.
Panday A, Inda ME, Bagam P, Sahoo MK, Osorio D, Batra S. Panday A, et al. Arch Immunol Ther Exp (Warsz). 2016 Dec;64(6):463-483. doi: 10.1007/s00005-016-0405-y. Epub 2016 May 28. Arch Immunol Ther Exp (Warsz). 2016. PMID: 27236331 Review.
The chronic activation or dysregulation of NF-kappaB signaling is the central cause of pathogenesis in many disease conditions and, therefore, NF-kappaB is a major focus of therapeutic intervention. ...In this review, we provide an updated synopsis of the role of …
The chronic activation or dysregulation of NF-kappaB signaling is the central cause of pathogenesis in many disease conditions and, t …
Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases.
Bustamante J, Boisson-Dupuis S, Jouanguy E, Picard C, Puel A, Abel L, Casanova JL. Bustamante J, et al. Curr Opin Immunol. 2008 Feb;20(1):39-48. doi: 10.1016/j.coi.2007.10.005. Curr Opin Immunol. 2008. PMID: 18083507 Review.
Human primary immunodeficiencies impairing myeloid and/or lymphoid cellular responses to activating receptors other than antigen receptors have recently been described in children with various infectious diseases. Germline mutations in NEMO and IKBA impair NF-kappaB-mediat …
Human primary immunodeficiencies impairing myeloid and/or lymphoid cellular responses to activating receptors other than antigen receptors h …
Herpes simplex type 1 induction of persistent NF-kappa B nuclear translocation increases the efficiency of virus replication.
Patel A, Hanson J, McLean TI, Olgiate J, Hilton M, Miller WE, Bachenheimer SL. Patel A, et al. Virology. 1998 Aug 1;247(2):212-22. doi: 10.1006/viro.1998.9243. Virology. 1998. PMID: 9705914 Free article.
The latent form of the dimeric transcription factor NF-kappa B is sequestered in the cytoplasm by proteins containing ankyrin repeats, such as 1 kappa B alpha and beta, or by the p105 precursor form of the NF-kappa B p50 sub …
The latent form of the dimeric transcription factor NF-kappa B is sequestered in the cytoplasm by proteins containing a …
Wogonin inhibits in vitro herpes simplex virus type 1 and 2 infection by modulating cellular NF-κB and MAPK pathways.
Chu Y, Lv X, Zhang L, Fu X, Song S, Su A, Chen D, Xu L, Wang Y, Wu Z, Yun Z. Chu Y, et al. BMC Microbiol. 2020 Jul 28;20(1):227. doi: 10.1186/s12866-020-01916-2. BMC Microbiol. 2020. PMID: 32723300 Free PMC article.
BACKGROUND: Wogonin, a natural flavonoid-like chemical compound, exhibits anti-inflammatory, antitumor, antiviral, neuroprotective, and anxiolytic effects by modulating a variety of cellular signaling pathways including PI3K-Akt, p53, nuclear factor kappaB (NF-kappaB), mit …
BACKGROUND: Wogonin, a natural flavonoid-like chemical compound, exhibits anti-inflammatory, antitumor, antiviral, neuroprotective, and anxi …
251 results