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148 results

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Page 1
The Taxus genome provides insights into paclitaxel biosynthesis.
Xiong X, Gou J, Liao Q, Li Y, Zhou Q, Bi G, Li C, Du R, Wang X, Sun T, Guo L, Liang H, Lu P, Wu Y, Zhang Z, Ro DK, Shang Y, Huang S, Yan J. Xiong X, et al. Nat Plants. 2021 Aug;7(8):1026-1036. doi: 10.1038/s41477-021-00963-5. Epub 2021 Jul 15. Nat Plants. 2021. PMID: 34267359 Free PMC article.
The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug paclitaxel, yet no reference genome sequences are available for comprehensively elucidating the paclitaxel biosynthesis pathway. We have completed a chromosome-level genome of Taxus chinen
The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug paclitaxel, yet no reference genome sequences are availabl …
Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III.
Jiang B, Gao L, Wang H, Sun Y, Zhang X, Ke H, Liu S, Ma P, Liao Q, Wang Y, Wang H, Liu Y, Du R, Rogge T, Li W, Shang Y, Houk KN, Xiong X, Xie D, Huang S, Lei X, Yan J. Jiang B, et al. Science. 2024 Feb 9;383(6683):622-629. doi: 10.1126/science.adj3484. Epub 2024 Jan 25. Science. 2024. PMID: 38271490
In this work, we identified a bifunctional cytochrome P450 enzyme [taxane oxetanase 1 (TOT1)] in Taxus mairei that catalyzes an oxidative rearrangement in paclitaxel oxetane formation, which represents a previously unknown enzyme mechanism for oxetane ring formation …
In this work, we identified a bifunctional cytochrome P450 enzyme [taxane oxetanase 1 (TOT1)] in Taxus mairei that catalyzes a …
Nigrospora musae Causing Taxus chinensis var. mairei stem blight in Sichuan, China.
Chen X, Xu X, Yuan H, Luo T, Cui H, Zhu T, Li S, Liu Y, Lin T, Qiao T, Yang C, Li S, Xie L, Dong J, Han S. Chen X, et al. Plant Dis. 2023 May 4. doi: 10.1094/PDIS-08-22-1892-PDN. Online ahead of print. Plant Dis. 2023. PMID: 37142964 Free article.
Taxus chinensis var. mairei is the endemic, endangered, and first-class protected tree species in China. ...
Taxus chinensis var. mairei is the endemic, endangered, and first-class protected tree species in China. ...
Response of rhizosphere bacterial community of Taxus chinensis var. mairei to temperature changes.
Yu X, Liu X, Liu X. Yu X, et al. PLoS One. 2019 Dec 12;14(12):e0226500. doi: 10.1371/journal.pone.0226500. eCollection 2019. PLoS One. 2019. PMID: 31830112 Free PMC article.
BACKGROUND: Temperature is a key factor influencing the growth and distribution of Taxus chinensis var. mairei, which is of high medicinal value. However, there is little information about the changes in rhizosphere bacterial community of Taxus chinens …
BACKGROUND: Temperature is a key factor influencing the growth and distribution of Taxus chinensis var. mairei, …
Aqueous extract of Taxus chinensis var. mairei targeting CD47 enhanced antitumor effects in non-small cell lung cancer.
Dai S, Liu Y, Zhao F, Wang H, Shao T, Xu Z, Shou L, Chen S, Zhang GC, Shu Q. Dai S, et al. Biomed Pharmacother. 2022 Oct;154:113628. doi: 10.1016/j.biopha.2022.113628. Epub 2022 Sep 1. Biomed Pharmacother. 2022. PMID: 36058145 Free article.
Immunoglobulin protein CD47 is overexpressed in malignant tumor cells, allowing them to evade host immunity mainly by inhibiting macrophage-mediated phagocytosis. Taxus chinensis var. mairei (TC) exhibits high antitumor efficacy with low toxicity and n …
Immunoglobulin protein CD47 is overexpressed in malignant tumor cells, allowing them to evade host immunity mainly by inhibiting macrophage- …
Insights from multi-omics integration into seed germination of Taxus chinensis var mairei.
Chen L, Qin L, Zhang Y, Xu H, Bu Y, Wu R, Liu H, Hao Q, Hu H, Zhou Y, Feng J, Jing Y, Han J, Wang X. Chen L, et al. Commun Biol. 2023 Sep 11;6(1):931. doi: 10.1038/s42003-023-05307-x. Commun Biol. 2023. PMID: 37697020 Free PMC article.
The transition from deep dormancy to seed germination is essential for the life cycle of plants, but how this process occurs in the gymnosperm Chinese yew (Taxus chinensis var mairei), the natural source of the anticancer drug paclitaxel, remains uncle …
The transition from deep dormancy to seed germination is essential for the life cycle of plants, but how this process occurs in the gymnospe …
A new taxane diterpenoid from Taxus chinensis var. mairei.
Zhou ZH, Qu W, Liu MZ, Sun JB, Wang MH, Liang JY, Wu FH. Zhou ZH, et al. Nat Prod Res. 2014;28(8):530-3. doi: 10.1080/14786419.2014.881360. Epub 2014 Feb 28. Nat Prod Res. 2014. PMID: 24579793
Taxadiene (3), a new taxane diterpenoid with an unusual hydroxy substituting at C-17, and six known compounds including two taxane diterpenoids (1 and 2) and four flavonoids (4-7) were isolated from the whole seedling of the Taxus chinensis var. mairei
Taxadiene (3), a new taxane diterpenoid with an unusual hydroxy substituting at C-17, and six known compounds including two taxane diterpeno …
148 results