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EULAR recommendations for the management of antiphospholipid syndrome in adults.
Tektonidou MG, Andreoli L, Limper M, Amoura Z, Cervera R, Costedoat-Chalumeau N, Cuadrado MJ, Dörner T, Ferrer-Oliveras R, Hambly K, Khamashta MA, King J, Marchiori F, Meroni PL, Mosca M, Pengo V, Raio L, Ruiz-Irastorza G, Shoenfeld Y, Stojanovich L, Svenungsson E, Wahl D, Tincani A, Ward MM. Tektonidou MG, et al. Ann Rheum Dis. 2019 Oct;78(10):1296-1304. doi: 10.1136/annrheumdis-2019-215213. Epub 2019 May 15. Ann Rheum Dis. 2019. PMID: 31092409
The objective was to develop evidence-based recommendations for the management of antiphospholipid syndrome (APS) in adults. Based on evidence from a systematic literature review and expert opinion, overarching principles and recommendations were formulated and voted. High …
The objective was to develop evidence-based recommendations for the management of antiphospholipid syndrome (APS) in adults. Based on …
Increased risk of thrombosis in antiphospholipid syndrome patients treated with direct oral anticoagulants. Results from an international patient-level data meta-analysis.
Dufrost V, Risse J, Reshetnyak T, Satybaldyeva M, Du Y, Yan XX, Salta S, Gerotziafas G, Jing ZC, Elalamy I, Wahl D, Zuily S. Dufrost V, et al. Autoimmun Rev. 2018 Oct;17(10):1011-1021. doi: 10.1016/j.autrev.2018.04.009. Epub 2018 Aug 11. Autoimmun Rev. 2018. PMID: 30103045 Review.
Rates of recurrent thromboses were 16.9% and 15% in APS patients receiving either anti-Xa inhibitors or dabigatran respectively. Triple positivity (positivity for all three antiphospholipid antibodies) was associated with a four-fold increased risk of recurrent thro …
Rates of recurrent thromboses were 16.9% and 15% in APS patients receiving either anti-Xa inhibitors or dabigatran respectively. Trip …
Antiphospholipid antibodies and the risk of thrombocytopenia in patients with systemic lupus erythematosus: A systematic review and meta-analysis.
Chock YP, Moulinet T, Dufrost V, Erkan D, Wahl D, Zuily S. Chock YP, et al. Autoimmun Rev. 2019 Nov;18(11):102395. doi: 10.1016/j.autrev.2019.102395. Epub 2019 Sep 11. Autoimmun Rev. 2019. PMID: 31520800
METHODS: We evaluated the role of antiphospholipid antibodies (aPL) and different aPL profiles on the risk of thrombocytopenia in SLE patients by conducting a systematic review and meta-analysis of available literature from 1987 to 2018. ...Among aPL subtypes, the risk of …
METHODS: We evaluated the role of antiphospholipid antibodies (aPL) and different aPL profiles on the risk of thrombocytopenia in SLE …
Use of direct oral anticoagulants in patients with thrombotic antiphospholipid syndrome: Guidance from the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis.
Zuily S, Cohen H, Isenberg D, Woller SC, Crowther M, Dufrost V, Wahl D, Doré CJ, Cuker A, Carrier M, Pengo V, Devreese KMJ. Zuily S, et al. J Thromb Haemost. 2020 Sep;18(9):2126-2137. doi: 10.1111/jth.14935. J Thromb Haemost. 2020. PMID: 32881337
Clarity and guidance is required with regard to the use of direct oral anticoagulants in antiphospholipid syndrome (APS) patients, within the confines of the recent European Medicines Agency recommendations, discrepant recommendations in other international guidelines and …
Clarity and guidance is required with regard to the use of direct oral anticoagulants in antiphospholipid syndrome (APS) patients, wi …
The (non-)sense of detecting anti-cardiolipin and anti-beta2glycoprotein I IgM antibodies in the antiphospholipid syndrome.
Chayoua W, Kelchtermans H, Gris JC, Moore GW, Musiał J, Wahl D, de Groot PG, de Laat B, Devreese KMJ. Chayoua W, et al. J Thromb Haemost. 2020 Jan;18(1):169-179. doi: 10.1111/jth.14633. Epub 2019 Sep 27. J Thromb Haemost. 2020. PMID: 31519058
BACKGROUND: The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with the persistent presence of lupus anticoagulant (LAC), anti-cardiolipin (aCL) and/or anti-beta2glycoprotein I (abeta2GPI) antibodies of the immunoglo …
BACKGROUND: The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with the persistent presenc …
Efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies: an international and collaborative meta-analysis.
Arnaud L, Mathian A, Ruffatti A, Erkan D, Tektonidou M, Cervera R, Forastiero R, Pengo V, Lambert M, Martinez-Zamora MA, Balasch J, Zuily S, Wahl D, Amoura Z. Arnaud L, et al. Autoimmun Rev. 2014 Mar;13(3):281-91. doi: 10.1016/j.autrev.2013.10.014. Epub 2013 Nov 2. Autoimmun Rev. 2014. PMID: 24189281 Review.
We performed a meta-analysis to determine whether aspirin has a significant protective effect on risk of first thrombosis among patients with antiphospholipid antibodies (aPL+). Observational and interventional studies identified from the Medline, Embase and Cochrane datab …
We performed a meta-analysis to determine whether aspirin has a significant protective effect on risk of first thrombosis among patients wit …
The relevance of "non-criteria" clinical manifestations of antiphospholipid syndrome: 14th International Congress on Antiphospholipid Antibodies Technical Task Force Report on Antiphospholipid Syndrome Clinical Features.
Abreu MM, Danowski A, Wahl DG, Amigo MC, Tektonidou M, Pacheco MS, Fleming N, Domingues V, Sciascia S, Lyra JO, Petri M, Khamashta M, Levy RA. Abreu MM, et al. Autoimmun Rev. 2015 May;14(5):401-14. doi: 10.1016/j.autrev.2015.01.002. Epub 2015 Jan 29. Autoimmun Rev. 2015. PMID: 25641203 Free article. Review.
The next step can be a critical redefinition of an APS gold standard, for instance derived from the APS ACTION registry that will include not only current APS patients but also those with antiphospholipid antibodies not meeting current classification criteria....
The next step can be a critical redefinition of an APS gold standard, for instance derived from the APS ACTION registry that will include no …
Detection of Anti-Cardiolipin and Anti-beta2glycoprotein I Antibodies Differs between Platforms without Influence on Association with Clinical Symptoms.
Chayoua W, Kelchtermans H, Moore GW, Gris JC, Musial J, Wahl D, Zuily S, Gianniello F, Fontana P, Remijn J, Urbanus RT, de Laat B, Devreese KMJ. Chayoua W, et al. Thromb Haemost. 2019 May;119(5):797-806. doi: 10.1055/s-0039-1679901. Epub 2019 Mar 1. Thromb Haemost. 2019. PMID: 30822809
BACKGROUND: The anti-phospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with persistent presence of anti-phospholipid antibodies (aPL). Laboratory criteria include aPL detection by coagulation tests for lupus anticoag …
BACKGROUND: The anti-phospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with persistent pre …
Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis: Update of the guidelines for lupus anticoagulant detection and interpretation.
Devreese KMJ, de Groot PG, de Laat B, Erkan D, Favaloro EJ, Mackie I, Martinuzzo M, Ortel TL, Pengo V, Rand JH, Tripodi A, Wahl D, Cohen H. Devreese KMJ, et al. J Thromb Haemost. 2020 Nov;18(11):2828-2839. doi: 10.1111/jth.15047. J Thromb Haemost. 2020. PMID: 33462974
Also, routine coagulation tests are advised to obtain more information on the coagulation background of the patient, and when necessary, anti-Xa activity measurement for heparins or specific assays for direct oral anticoagulants should be performed. ...
Also, routine coagulation tests are advised to obtain more information on the coagulation background of the patient, and when necessary, …
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