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2007 2
2008 1
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2012 1
2013 2
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Page 1
Health-related quality of life in patients with microsatellite instability-high or mismatch repair deficient metastatic colorectal cancer treated with first-line pembrolizumab versus chemotherapy (KEYNOTE-177): an open-label, randomised, phase 3 trial.
Andre T, Amonkar M, Norquist JM, Shiu KK, Kim TW, Jensen BV, Jensen LH, Punt CJA, Smith D, Garcia-Carbonero R, Sevilla I, De La Fouchardiere C, Rivera F, Elez E, Diaz LA Jr, Yoshino T, Van Cutsem E, Yang P, Farooqui M, Le DT. Andre T, et al. Lancet Oncol. 2021 May;22(5):665-677. doi: 10.1016/S1470-2045(21)00064-4. Epub 2021 Apr 1. Lancet Oncol. 2021. PMID: 33812497 Clinical Trial.
HRQOL outcomes were mean change from baseline to prespecified week 18 in European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and EORTC Quality of Life Questionnaire-Colorectal 29 (EORTC QLQ-CR29) scale and item scores, …
HRQOL outcomes were mean change from baseline to prespecified week 18 in European Organisation for Research and Treatment of Cancer Quality …
Nivolumab plus ipilimumab versus chemotherapy as first-line treatment in advanced non-small-cell lung cancer with high tumour mutational burden: patient-reported outcomes results from the randomised, open-label, phase III CheckMate 227 trial.
Reck M, Schenker M, Lee KH, Provencio M, Nishio M, Lesniewski-Kmak K, Sangha R, Ahmed S, Raimbourg J, Feeney K, Corre R, Franke FA, Richardet E, Penrod JR, Yuan Y, Nathan FE, Bhagavatheeswaran P, DeRosa M, Taylor F, Lawrance R, Brahmer J. Reck M, et al. Eur J Cancer. 2019 Jul;116:137-147. doi: 10.1016/j.ejca.2019.05.008. Epub 2019 Jun 11. Eur J Cancer. 2019. PMID: 31195357 Free article. Clinical Trial.
During treatment, mean changes from baseline with nivolumab + ipilimumab showed early, clinically meaningful improvements in LCSS ASBI/3-IGI and EQ-5D VAS/UI; with chemotherapy, symptoms and health-related quality of life remained stable (LCSS ASBI/3-IGI, EQ-5D UI) …
During treatment, mean changes from baseline with nivolumab + ipilimumab showed early, clinically meaningful improvements in LCSS ASBI/3-IGI …
Improvement in patient-reported outcomes and work productivity following 3-year ustekinumab or tumour necrosis factor inhibitor treatment in patients with psoriatic arthritis: results from the PsABio real-world study.
Gossec L, Siebert S, Bergmans P, de Vlam K, Gremese E, Joven-Ibáñez B, Korotaeva TV, Lavie F, Noël W, Nurmohamed MT, Sfikakis PP, Sharaf M, Theander E, Smolen JS. Gossec L, et al. Arthritis Res Ther. 2023 Jun 23;25(1):109. doi: 10.1186/s13075-023-03058-y. Arthritis Res Ther. 2023. PMID: 37353788 Free PMC article.
METHODS: In PsABio (NCT02627768), a prospective, observational study, patients with PsA that were prescribed first- to third-line ustekinumab or a TNFi, and remained on that drug for 3 years, were analysed for change in baseline in PROs (EuroQol-5 dimensions health state VAS [EQ- …
METHODS: In PsABio (NCT02627768), a prospective, observational study, patients with PsA that were prescribed first- to third-line ustekinuma …
A head-to-head comparison of the EQ-5D-5L and 15D descriptive systems and index values in a general population sample.
Nikl A, Janssen MF, Brodszky V, Rencz F. Nikl A, et al. Health Qual Life Outcomes. 2023 Feb 19;21(1):17. doi: 10.1186/s12955-023-02096-z. Health Qual Life Outcomes. 2023. PMID: 36803866 Free PMC article.
The 15D index values showed lower ceiling than the EQ-5D-5L (21% vs. 36%). The mean index values were 0.86 for the Danish EQ-5D-5L, 0.87 for the Hungarian EQ-5D-5L, 0.91 for the Danish 15D and 0.81 for the Norwegian 15D. Strong correlations were found between …
The 15D index values showed lower ceiling than the EQ-5D-5L (21% vs. 36%). The mean index values were 0.86 for the Danish EQ-5D …
Analysis of intervertebral discs adjacent to thoracolumbar A3 fractures treated by percutaneous instrumentation and kyphoplasty.
Collinet A, Charles YP, Ntilikina Y, Tuzin N, Steib JP. Collinet A, et al. Orthop Traumatol Surg Res. 2020 Oct;106(6):1221-1226. doi: 10.1016/j.otsr.2020.05.006. Epub 2020 Sep 2. Orthop Traumatol Surg Res. 2020. PMID: 32888918 Free article. Review.
The Pfirrmann grade was determined on an MRI taken at the final assessment. Clinical scores were the pain level (VAS), EQ-5D-3L, and ODI. The relationships between Pfirrmann grades, age and radiographic parameters were analyzed. ...At the final assessment, the average pain …
The Pfirrmann grade was determined on an MRI taken at the final assessment. Clinical scores were the pain level (VAS), EQ-5D-3L, and …
Systematic Literature Review of Economic Evaluations of Biological Treatment Sequences for Patients with Moderate to Severe Rheumatoid Arthritis Previously Treated with Disease-Modifying Anti-rheumatic Drugs.
Ghabri S, Lam L, Bocquet F, Spath HM. Ghabri S, et al. Pharmacoeconomics. 2020 May;38(5):459-471. doi: 10.1007/s40273-020-00887-6. Pharmacoeconomics. 2020. PMID: 32052376 Review.
Individual models such as discrete-event simulations were used in over two-fifths (22/51, 43%) of the selected studies. Few studies (7/51, 14%) used utility scores based on generic instruments (e.g. EQ-5D). Estimation of hospitalization costs was described in only a …
Individual models such as discrete-event simulations were used in over two-fifths (22/51, 43%) of the selected studies. Few studies ( …
Feed restriction to induce and meloxicam to mitigate potential systemic inflammation in dairy cows before calving.
Pascottini OB, Carvalho MR, Van Schyndel SJ, Ticiani E, Spricigo JW, Mamedova LK, Ribeiro ES, LeBlanc SJ. Pascottini OB, et al. J Dairy Sci. 2019 Oct;102(10):9285-9297. doi: 10.3168/jds.2019-16558. Epub 2019 Aug 7. J Dairy Sci. 2019. PMID: 31400891 Free article.
Holstein cows (n = 45) were assigned to control (n = 13), feed restriction (FR) untreated (FR-U; n = 15), and FR treated with MEL (FR-T; n = 17) groups. Daily feed intake was measured from -22 d from expected parturition until 35 d postpartum. C …
Holstein cows (n = 45) were assigned to control (n = 13), feed restriction (FR) untreated (FR-U; n = 15), and FR treate …
Folate receptor targeted alpha-therapy using terbium-149.
Müller C, Reber J, Haller S, Dorrer H, Köster U, Johnston K, Zhernosekov K, Türler A, Schibli R. Müller C, et al. Pharmaceuticals (Basel). 2014 Mar 13;7(3):353-65. doi: 10.3390/ph7030353. Pharmaceuticals (Basel). 2014. PMID: 24633429 Free PMC article.
The goal of this study was to investigate the anticancer efficacy of a 149Tb-labeled DOTA-folate conjugate (cm09) using folate receptor (FR)-positive cancer cells in vitro and in tumor-bearing mice. 149Tb was produced at the ISOLDE facility at CERN. ...In vitro assays perf …
The goal of this study was to investigate the anticancer efficacy of a 149Tb-labeled DOTA-folate conjugate (cm09) using folate receptor ( …
General and Skin-Specific Health-Related Quality of Life in Patients With Atopic Dermatitis Before and During the COVID-19 Pandemic.
Koszorú K, Hajdu K, Brodszky V, Szabó Á, Borza J, Bodai K, Pónyai G, Szegedi A, Sárdy M, Rencz F. Koszorú K, et al. Dermatitis. 2022 Nov-Dec 01;33(6S):S92-S103. doi: 10.1097/DER.0000000000000908. Epub 2022 Jun 8. Dermatitis. 2022. PMID: 35674639 Free PMC article.
Severity was measured using objective SCORing Atopic Dermatitis, Eczema Area and Severity Index, and Investigator Global Assessment. RESULTS: The mean SD EQ-5D-5L utility, Skindex-16, DLQI, and DLQI-R scores were 0.82 0.22, 56.84 27.46, 13.44 8.46, and 13.76 8.60, r …
Severity was measured using objective SCORing Atopic Dermatitis, Eczema Area and Severity Index, and Investigator Global Assessment. RESULTS …
Anatomy of the epidemiological literature on the 2003 SARS outbreaks in Hong Kong and Toronto: a time-stratified review.
Xing W, Hejblum G, Leung GM, Valleron AJ. Xing W, et al. PLoS Med. 2010 May 4;7(5):e1000272. doi: 10.1371/journal.pmed.1000272. PLoS Med. 2010. PMID: 20454570 Free PMC article. Review.
Descriptive, analytical, theoretical, and experimental epidemiology concerned, respectively, 54%, 30%, 11%, and 6% of the studies. Only 22% of the studies were submitted, 8% accepted, and 7% published during the epidemic. ...
Descriptive, analytical, theoretical, and experimental epidemiology concerned, respectively, 54%, 30%, 11%, and 6% of the studies. Only 2 …
58 results