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Page 1
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Liu K, Qiu D, Liang X, Huang Y, Wang Y, Jia X, Li K, Zhao J, Du C, Qiu X, Cui J, Xiao Z, Qin Y, Zhang Q. Liu K, et al. Autophagy. 2022 Apr;18(4):860-876. doi: 10.1080/15548627.2021.1961072. Epub 2021 Aug 12. Autophagy. 2022. PMID: 34382907 Free PMC article.
Our findings may facilitate the development of new strategies for clinical treatment of hepatic steatosis.Abbreviations: AA: amino acid; ACTB: actin beta; cGAMP: cyclic GMP-AMP; CGAS: cyclic GMP-AMP synthase; DEPTOR: DEP domain containing MTOR interacting protein; EIF4EBP1: eukar …
Our findings may facilitate the development of new strategies for clinical treatment of hepatic steatosis.Abbreviations: AA: amino acid; ACT …
Characterization of a Cytopathogenic Reporter CSFV.
Reuscher CM, Schmidt L, Netsch A, Lamp B. Reuscher CM, et al. Viruses. 2021 Jun 23;13(7):1209. doi: 10.3390/v13071209. Viruses. 2021. PMID: 34201706 Free PMC article.
Cp strains of BVDV have been used as naturally attenuated live vaccines and for species-specific plaque reduction tests for the indirect serological detection of BVDV. ...This genetically stabilized cp CSFV strain could be further used as a basis for potential new modified …
Cp strains of BVDV have been used as naturally attenuated live vaccines and for species-specific plaque reduction tests for the indir …
Development of an optimized RT-LAMP test for the detection of SARS-CoV-2.
Momenifar N, Pirouzfar M, Hashemian Z, Daneshvar Amoli A. Momenifar N, et al. Biologicals. 2023 Nov;84:101716. doi: 10.1016/j.biologicals.2023.101716. Epub 2023 Oct 4. Biologicals. 2023. PMID: 37801803
There are several measures for control and prevention of Covid-19 including using mask, vaccine injections, as well as screening the potential cases. We aimed to design and develop a molecular method (RT-LAMP) for detecting coronavirus in biological samples that is …
There are several measures for control and prevention of Covid-19 including using mask, vaccine injections, as well as screening the …
Bis-benzylisoquinoline alkaloids inhibit African swine fever virus internalization and replication by impairing late endosomal/lysosomal function.
Zhu J, Chen H, Gao F, Jian W, Huang G, Sunkang Y, Chen X, Liao M, Zhang K, Qi W, Huang L. Zhu J, et al. J Virol. 2024 Aug 20;98(8):e0032724. doi: 10.1128/jvi.00327-24. Epub 2024 Jul 31. J Virol. 2024. PMID: 39082785 Free PMC article.
It exhibits an alarming acute infection fatality rate of up to 100%. Regrettably, no commercial vaccines or specific drugs for combating this disease are currently available. This study evaluated the anti-ASFV activities in porcine alveolar macrophages, 3D4/21 cells, and P …
It exhibits an alarming acute infection fatality rate of up to 100%. Regrettably, no commercial vaccines or specific drugs for combat …
Reports of New and Recurrent Keratitis following mRNA-based COVID-19 Vaccination.
Shah PP, Glidai Y, Braunstein R, Gorski M, Lee J, Anwar F, Schrier A, Winokur J, Steiner AS. Shah PP, et al. Ocul Immunol Inflamm. 2023 Aug;31(6):1169-1174. doi: 10.1080/09273948.2022.2133730. Epub 2022 Nov 7. Ocul Immunol Inflamm. 2023. PMID: 36345233
PURPOSE: As ophthalmic side effects of messenger RNA (mRNA)-based COVID-19 vaccination are not well understood, it is crucial to document and report such instances should they occur. ...CONCLUSIONS: The immunological reaction following mRNA-base …
PURPOSE: As ophthalmic side effects of messenger RNA (mRNA)-based COVID-19 vaccination are not well understood, …
Lassa Virus Structural Biology and Replication.
Garry RF. Garry RF. Curr Top Microbiol Immunol. 2023;440:147-164. doi: 10.1007/82_2023_262. Curr Top Microbiol Immunol. 2023. PMID: 37100973
Large is a polymerase that catalyzes viral RNA transcription and replication. LASV virion entry occurs via a clathrin-independent endocytic pathway usually involving alpha-dystroglycan and lysosomal associated membrane protein 1 as surface and intracellular r …
Large is a polymerase that catalyzes viral RNA transcription and replication. LASV virion entry occurs via a clathrin-independent end …
Lit-LAMP-DNA-vaccine for shrimp allergy prevents anaphylactic symptoms in a murine model.
Kubo K, Takeda S, Uchida M, Maeda M, Endo N, Sugahara S, Suzuki H, Fukahori H. Kubo K, et al. Int Immunopharmacol. 2022 Dec;113(Pt A):109394. doi: 10.1016/j.intimp.2022.109394. Epub 2022 Nov 2. Int Immunopharmacol. 2022. PMID: 36334369
Here, we investigated the potential of a single DNA plasmid vaccine (Lit-LAMP-DNA-vaccine) encoding multivalent shrimp antigens (Lit v (Litopenaeus vannamei; Whiteleg shrimp) 1, Lit v4, and Lit v3) and a lysosomal-associated membra …
Here, we investigated the potential of a single DNA plasmid vaccine (Lit-LAMP-DNA-vaccine) encoding multi …
DNA Vaccines Against Maedi-Visna Virus.
Henriques AM, Fevereiro M, Monteiro GA. Henriques AM, et al. Methods Mol Biol. 2016;1404:59-76. doi: 10.1007/978-1-4939-3389-1_4. Methods Mol Biol. 2016. PMID: 27076290
Therefore, measures aiming at the control of MVV infection are necessary, and the development of DNA vaccines may be the ideal approach. A DNA vaccine is an antigen-encoding bacterial plasmid designed to mimic infections safely, with ability to generat …
Therefore, measures aiming at the control of MVV infection are necessary, and the development of DNA vaccines may be the ideal …
Development and Characterization of an HCMV Multi-Antigen Therapeutic Vaccine for Glioblastoma Using the UNITE Platform.
Adhikari AS, Macauley J, Johnson Y, Connolly M, Coleman T, Heiland T. Adhikari AS, et al. Front Oncol. 2022 May 16;12:850546. doi: 10.3389/fonc.2022.850546. eCollection 2022. Front Oncol. 2022. PMID: 35651802 Free PMC article.
We utilized our UNITE (UNiversal Intracellular Targeted Expression) platform to develop a multi-antigen DNA vaccine (ITI-1001) that codes for the HCMV proteins pp65, gB, and IE-1. The UNITE platform involves lysosomal targeting technology, fusing ly …
We utilized our UNITE (UNiversal Intracellular Targeted Expression) platform to develop a multi-antigen DNA vaccine (ITI-1001) …
Melanoma LAMP-2C Modulates Tumor Growth and Autophagy.
Pérez L, Sinn AL, Sandusky GE, Pollok KE, Blum JS. Pérez L, et al. Front Cell Dev Biol. 2018 Aug 29;6:101. doi: 10.3389/fcell.2018.00101. eCollection 2018. Front Cell Dev Biol. 2018. PMID: 30211163 Free PMC article.
This report documents a novel inhibitory role for a lysosome-associated membrane protein, LAMP-2C in modulating autophagy and melanoma cell growth in vitro and in vivo. ...In vitro analysis showed increasing LAMP-2C expression in a melanoma cell line, …
This report documents a novel inhibitory role for a lysosome-associated membrane protein, LAMP-2C in modulating autopha …
178 results