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Year Number of Results
2003 1
2004 4
2005 4
2006 3
2007 3
2008 4
2009 2
2010 3
2011 3
2012 3
2013 2
2014 5
2015 9
2016 6
2017 4
2018 7
2019 1
2020 4
2021 2
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64 results
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Page 1
Protein disulfide isomerase a4 acts as a novel regulator of cancer growth through the procaspase pathway.
Kuo TF, Chen TY, Jiang ST, Chen KW, Chiang YM, Hsu YJ, Liu YJ, Chen HM, Yokoyama KK, Tsai KC, Yeh HH, Chen YR, Yang MT, Yang CY, Yang WC. Kuo TF, et al. Oncogene. 2017 Sep 28;36(39):5484-5496. doi: 10.1038/onc.2017.156. Epub 2017 May 22. Oncogene. 2017. PMID: 28534513
Protein disulfide isomerase a4 (PDIA4) is implicated in the growth and death of tumor cells; however, its molecular mechanism and therapeutic potential in cancer are unclear. ...Finally, we found that 1,2-dihydroxytrideca-5,7,9,11-tetrayne, a PDIA4 inh
Protein disulfide isomerase a4 (PDIA4) is implicated in the growth and death of tumor cells; however, its molecu
A traditional Chinese medicine formula NRICM101 to target COVID-19 through multiple pathways: A bedside-to-bench study.
Tsai KC, Huang YC, Liaw CC, Tsai CI, Chiou CT, Lin CJ, Wei WC, Lin SJ, Tseng YH, Yeh KM, Lin YL, Jan JT, Liang JJ, Liao CC, Chiou WF, Kuo YH, Lee SM, Lee MY, Su YC. Tsai KC, et al. Biomed Pharmacother. 2021 Jan;133:111037. doi: 10.1016/j.biopha.2020.111037. Epub 2020 Nov 19. Biomed Pharmacother. 2021. PMID: 33249281 Free PMC article.
No therapies or vaccines so far are recommended to treat or prevent the new coronavirus. A novel traditional Chinese medicine formula, Taiwan Chingguan Yihau (NRICM101), has been administered to patients with COVID-19 in Taiwan since April 2020. ...Pharmacological assays d …
No therapies or vaccines so far are recommended to treat or prevent the new coronavirus. A novel traditional Chinese medicine formula …
Generation and characterization of avian-derived anti-human CD19 single chain fragment antibodies.
Tsai KC, Chiang CW, Lo YN, Chang FL, Lin TY, Chang CY, Chen WC, Lee YC. Tsai KC, et al. Anim Biotechnol. 2019 Oct;30(4):293-301. doi: 10.1080/10495398.2018.1486323. Epub 2018 Sep 27. Anim Biotechnol. 2019. PMID: 30261812
After constructing a scFv antibody library with 2.5 10(8) compositional diversity for panning, one representative scFv clone S2 which can specifically recognize to the CD19 protein was isolated and characterized. The binding reactivity of the scFv S2 to the endogenous CD19 …
After constructing a scFv antibody library with 2.5 10(8) compositional diversity for panning, one representative scFv clone S2 which can sp …
How to generate reliable and predictive CoMFA models.
Zhang L, Tsai KC, Du L, Fang H, Li M, Xu W. Zhang L, et al. Among authors: tsai kc. Curr Med Chem. 2011;18(6):923-30. doi: 10.2174/092986711794927702. Curr Med Chem. 2011. PMID: 21182474 Review.
Accordingly, so far numerous endeavors have been accomplished to ameliorate the CoMFA model's robustness and predictive accuracy by considering various factors, including molecular conformation and alignment, field descriptors and grid spacing. Herein, we would like to mak …
Accordingly, so far numerous endeavors have been accomplished to ameliorate the CoMFA model's robustness and predictive accuracy by c …
Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses.
Hsu PH, Chiu DC, Wu KL, Lee PS, Jan JT, Cheng YE, Tsai KC, Cheng TJ, Fang JM. Hsu PH, et al. Among authors: tsai kc. Eur J Med Chem. 2018 Jun 25;154:314-323. doi: 10.1016/j.ejmech.2018.05.030. Epub 2018 May 21. Eur J Med Chem. 2018. PMID: 29843102
The acylguanidine derivatives were prepared by coupling with either n-octanoic acid or (S)-naproxen. The lipophilic acyl substituents were verified to improve cell permeability, and may also improve the bioavailability of acylguanidine compounds. ...
The acylguanidine derivatives were prepared by coupling with either n-octanoic acid or (S)-naproxen. The lipophilic acyl substituents …
Isolation of anti-VEGF monoclonal antibodies with neutralizing effects from an Astragalus-induced immune antibody library.
Lee YC, Huang HT, Chang CD, Chen CT, Lin TY, Yang TW, Chang FL, Lu MK, Chiou CT, Chen WC, Pan SL, Tsai KC. Lee YC, et al. Among authors: tsai kc. Int Immunopharmacol. 2020 Nov;88:107007. doi: 10.1016/j.intimp.2020.107007. Epub 2020 Sep 18. Int Immunopharmacol. 2020. PMID: 33182041
In addition, this study indirectly expounded the correlations of APS enhancing immunity regulation in vivo....
In addition, this study indirectly expounded the correlations of APS enhancing immunity regulation in vivo....
Engineering a nanopore with co-chaperonin function.
Ho CW, Van Meervelt V, Tsai KC, De Temmerman PJ, Mast J, Maglia G. Ho CW, et al. Among authors: tsai kc. Sci Adv. 2015 Dec 11;1(11):e1500905. doi: 10.1126/sciadv.1500905. eCollection 2015 Dec. Sci Adv. 2015. PMID: 26824063 Free PMC article.
We engineered an alpha hemolysin nanopore to function as GroES, a protein that, in complex with GroEL, forms a two-stroke protein-folding nanomachine. The transmembrane co-chaperonin was prepared by recombination of GroES functional elements with the nanopore, sugge …
We engineered an alpha hemolysin nanopore to function as GroES, a protein that, in complex with GroEL, forms a two-stroke protein
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