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2015 2
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The Prescription Opioid Addiction Treatment Study: What have we learned.
Weiss RD, Rao V. Weiss RD, et al. Drug Alcohol Depend. 2017 Apr 1;173 Suppl 1(Suppl 1):S48-S54. doi: 10.1016/j.drugalcdep.2016.12.001. Drug Alcohol Depend. 2017. PMID: 28363320 Free PMC article. Clinical Trial.
BACKGROUND: The multi-site Prescription Opioid Addiction Treatment Study (POATS), conducted by the National Drug Abuse Treatment Clinical Trials Network, was the largest clinical trial yet conducted with patients dependent upon prescripti …
BACKGROUND: The multi-site Prescription Opioid Addiction Treatment Study (POATS), conducted by the National Drug Abu
Comparative effectiveness of extended-release naltrexone versus buprenorphine-naloxone for opioid relapse prevention (X:BOT): a multicentre, open-label, randomised controlled trial.
Lee JD, Nunes EV Jr, Novo P, Bachrach K, Bailey GL, Bhatt S, Farkas S, Fishman M, Gauthier P, Hodgkins CC, King J, Lindblad R, Liu D, Matthews AG, May J, Peavy KM, Ross S, Salazar D, Schkolnik P, Shmueli-Blumberg D, Stablein D, Subramaniam G, Rotrosen J. Lee JD, et al. Lancet. 2018 Jan 27;391(10118):309-318. doi: 10.1016/S0140-6736(17)32812-X. Epub 2017 Nov 14. Lancet. 2018. PMID: 29150198 Free PMC article. Clinical Trial.
We aimed to estimate the difference in opioid relapse-free survival between XR-NTX and BUP-NX. METHODS: We initiated this 24 week, open-label, randomised controlled, comparative effectiveness trial at eight US community-based inpatient services and followed u …
We aimed to estimate the difference in opioid relapse-free survival between XR-NTX and BUP-NX. METHODS: We initiated this 24 week, op …
Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes.
Kaltenbach K, O'Grady KE, Heil SH, Salisbury AL, Coyle MG, Fischer G, Martin PR, Stine S, Jones HE. Kaltenbach K, et al. Drug Alcohol Depend. 2018 Apr 1;185:40-49. doi: 10.1016/j.drugalcdep.2017.11.030. Epub 2018 Feb 1. Drug Alcohol Depend. 2018. PMID: 29413437 Free PMC article. Clinical Trial.
BACKGROUND: Methadone and buprenorphine are recommended to treat opioid use disorders during pregnancy. ...METHODS: Participants were 96 children and their mothers who participated in MOTHER, a randomized controlled trial of opioid-agonis …
BACKGROUND: Methadone and buprenorphine are recommended to treat opioid use disorders during pregnancy. ...METHODS: Participan …
Cost-effectiveness of emergency department-initiated treatment for opioid dependence.
Busch SH, Fiellin DA, Chawarski MC, Owens PH, Pantalon MV, Hawk K, Bernstein SL, O'Connor PG, D'Onofrio G. Busch SH, et al. Addiction. 2017 Nov;112(11):2002-2010. doi: 10.1111/add.13900. Epub 2017 Aug 16. Addiction. 2017. PMID: 28815789 Free PMC article. Clinical Trial.
BACKGROUND AND AIMS: In a recent randomized trial, patients with opioid dependence receiving brief intervention, emergency department (ED)-initiated buprenorphine and ongoing follow-up in primary care with buprenorphine (buprenorphine) were twice as li …
BACKGROUND AND AIMS: In a recent randomized trial, patients with opioid dependence receiving brief intervention, …
Weekly and Monthly Subcutaneous Buprenorphine Depot Formulations vs Daily Sublingual Buprenorphine With Naloxone for Treatment of Opioid Use Disorder: A Randomized Clinical Trial.
Lofwall MR, Walsh SL, Nunes EV, Bailey GL, Sigmon SC, Kampman KM, Frost M, Tiberg F, Linden M, Sheldon B, Oosman S, Peterson S, Chen M, Kim S. Lofwall MR, et al. JAMA Intern Med. 2018 Jun 1;178(6):764-773. doi: 10.1001/jamainternmed.2018.1052. JAMA Intern Med. 2018. PMID: 29799968 Free PMC article. Clinical Trial.
IMPORTANCE: Buprenorphine treatment for opioid use disorder may be improved by sustained-release formulations. ...Participants were treatment-seeking adults with moderate-to-severe opioid use disorder. ...
IMPORTANCE: Buprenorphine treatment for opioid use disorder may be improved by sustained-release formulations. ...Participants …
Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial.
Hurd YL, Spriggs S, Alishayev J, Winkel G, Gurgov K, Kudrich C, Oprescu AM, Salsitz E. Hurd YL, et al. Am J Psychiatry. 2019 Nov 1;176(11):911-922. doi: 10.1176/appi.ajp.2019.18101191. Epub 2019 May 21. Am J Psychiatry. 2019. PMID: 31109198 Clinical Trial.
METHODS: This exploratory double-blind randomized placebo-controlled trial assessed the acute (1 hour, 2 hours, and 24 hours), short-term (3 consecutive days), and protracted (7 days after the last of three consecutive daily administrations) effects of CBD ad …
METHODS: This exploratory double-blind randomized placebo-controlled trial assessed the acute (1 hour, 2 hours, and 24 …
Efficacy and safety of a monthly buprenorphine depot injection for opioid use disorder: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
Haight BR, Learned SM, Laffont CM, Fudala PJ, Zhao Y, Garofalo AS, Greenwald MK, Nadipelli VR, Ling W, Heidbreder C; RB-US-13-0001 Study Investigators. Haight BR, et al. Lancet. 2019 Feb 23;393(10173):778-790. doi: 10.1016/S0140-6736(18)32259-1. Epub 2019 Feb 18. Lancet. 2019. PMID: 30792007 Clinical Trial.
BACKGROUND: RBP-6000, referred to as BUP-XR (extended-release buprenorphine), is a subcutaneously injected, monthly buprenorphine treatment for opioid use disorder. BUP-XR provides sustained buprenorphine plasma concentrations to block drug-liking of abused opioi
BACKGROUND: RBP-6000, referred to as BUP-XR (extended-release buprenorphine), is a subcutaneously injected, monthly buprenorphine treatme
Efficacy of Tramadol Extended-Release for Opioid Withdrawal: A Randomized Clinical Trial.
Dunn KE, Tompkins DA, Bigelow GE, Strain EC. Dunn KE, et al. JAMA Psychiatry. 2017 Sep 1;74(9):885-893. doi: 10.1001/jamapsychiatry.2017.1838. JAMA Psychiatry. 2017. PMID: 28700791 Free PMC article. Clinical Trial.
Participants' treatment was stabilized with morphine, 30 mg, administered subcutaneously 4 times daily. ...Data support further examination of tramadol ER as a method to manage opioid withdrawal symptoms. TRIAL REGISTRATION: Clinicaltrials.gov I …
Participants' treatment was stabilized with morphine, 30 mg, administered subcutaneously 4 times daily. ...Data support furthe …
OPRM1 Methylation Contributes to Opioid Tolerance in Cancer Patients.
Viet CT, Dang D, Aouizerat BE, Miaskowski C, Ye Y, Viet DT, Ono K, Schmidt BL. Viet CT, et al. J Pain. 2017 Sep;18(9):1046-1059. doi: 10.1016/j.jpain.2017.04.001. Epub 2017 Apr 27. J Pain. 2017. PMID: 28456745 Free PMC article. Clinical Trial.
Cancer patients in pain require high doses of opioids and quickly become opioid-tolerant. Previous studies have shown that chronic cancer pain as well as high-dose opioid use lead to mu-opioid receptor downregulation. ...PERSPECTIVE: We demonstrate tha …
Cancer patients in pain require high doses of opioids and quickly become opioid-tolerant. Previous studies have shown that chr …
Effectiveness of Injectable Extended-Release Naltrexone vs Daily Buprenorphine-Naloxone for Opioid Dependence: A Randomized Clinical Noninferiority Trial.
Tanum L, Solli KK, Latif ZE, Benth JŠ, Opheim A, Sharma-Haase K, Krajci P, Kunøe N. Tanum L, et al. JAMA Psychiatry. 2017 Dec 1;74(12):1197-1205. doi: 10.1001/jamapsychiatry.2017.3206. JAMA Psychiatry. 2017. PMID: 29049469 Free PMC article. Clinical Trial.
IMPORTANCE: To date, extended-release naltrexone hydrochloride has not previously been compared directly with opioid medication treatment (OMT), currently the most commonly prescribed treatment for opioid dependence. ...MAIN OUTCOMES AND MEASURE …
IMPORTANCE: To date, extended-release naltrexone hydrochloride has not previously been compared directly with opioid medication tr
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