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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1964 2
1967 2
1968 1
1969 1
1970 2
1971 3
1972 1
1973 2
1975 2
1976 1
1977 2
1978 1
1981 6
1982 2
1983 1
1984 3
1985 4
1986 2
1987 1
1988 2
1989 4
1990 10
1991 3
1992 2
1993 2
1995 4
1996 7
1997 5
1998 6
1999 6
2000 7
2001 8
2002 4
2003 6
2004 8
2005 9
2006 9
2007 10
2008 8
2009 4
2010 17
2011 10
2012 14
2013 12
2014 16
2015 10
2016 17
2017 18
2018 9
2019 10
2020 8
2021 3
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281 results
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Page 1
Acute lymphoblastic leukemia in children with Down syndrome: Comparative analysis versus patients without Down syndrome.
Pennella CL, Rossi JG, Baialardo EM, Alonso CN, Guitter MR, Sánchez La Rosa CG, Millán NC, Alfaro EM, Zubizarreta PA, Felice MS. Pennella CL, et al. Arch Argent Pediatr. 2018 Aug 1;116(4):e500-e507. doi: 10.5546/aap.2018.eng.e500. Arch Argent Pediatr. 2018. PMID: 30016023 Free article. English, Spanish.

They showed a better response rate to prednisone (p= 0.09) and a higher mortality in induction and complete remission (p < 0.0001). All deaths of patients with DS-ALL were treatment-related. ...The EFI of patients with DS-ALL was lower in the group aged 6-9 years: 39% (

They showed a better response rate to prednisone (p= 0.09) and a higher mortality in induction and complete remission (p < 0.0001)

Neonatal characteristics and perinatal complications in neonates with Down syndrome.
Ergaz-Shaltiel Z, Engel O, Erlichman I, Naveh Y, Schimmel MS, Tenenbaum A. Ergaz-Shaltiel Z, et al. Am J Med Genet A. 2017 May;173(5):1279-1286. doi: 10.1002/ajmg.a.38165. Epub 2017 Apr 6. Am J Med Genet A. 2017. PMID: 28386951

In all gestational ages, the mean birth weight and head circumference percentiles were significantly lower than the general population (P < 0.001 for both) and at each week the HC percentile was lower than the weight percentile (P < 0.0001), worse among males. Mortality

In all gestational ages, the mean birth weight and head circumference percentiles were significantly lower than the general population (P &l …
Improved outcomes for myeloid leukemia of Down syndrome: a report from the Children's Oncology Group AAML0431 trial.
Taub JW, Berman JN, Hitzler JK, Sorrell AD, Lacayo NJ, Mast K, Head D, Raimondi S, Hirsch B, Ge Y, Gerbing RB, Wang YC, Alonzo TA, Campana D, Coustan-Smith E, Mathew P, Gamis AS. Taub JW, et al. Blood. 2017 Jun 22;129(25):3304-3313. doi: 10.1182/blood-2017-01-764324. Epub 2017 Apr 7. Blood. 2017. PMID: 28389462 Free PMC article. Clinical Trial.
Patients with myeloid leukemia of Down syndrome (ML-DS) have favorable event-free survival (EFS), but experience significant treatment-related morbidity and mortality. ...For 204 eligible patients, 5-year EFS was 89.9% and overall survival (OS) was 93.0%. The …
Patients with myeloid leukemia of Down syndrome (ML-DS) have favorable event-free survival (EFS), but experience significant treatmen …
Survival of children with mosaic Down syndrome.
Shin M, Siffel C, Correa A. Shin M, et al. Am J Med Genet A. 2010 Mar;152A(3):800-1. doi: 10.1002/ajmg.a.33295. Am J Med Genet A. 2010. PMID: 20186777 No abstract available.
Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group.
Buitenkamp TD, Izraeli S, Zimmermann M, Forestier E, Heerema NA, van den Heuvel-Eibrink MM, Pieters R, Korbijn CM, Silverman LB, Schmiegelow K, Liang DC, Horibe K, Arico M, Biondi A, Basso G, Rabin KR, Schrappe M, Cario G, Mann G, Morak M, Panzer-Grümayer R, Mondelaers V, Lammens T, Cavé H, Stark B, Ganmore I, Moorman AV, Vora A, Hunger SP, Pui CH, Mullighan CG, Manabe A, Escherich G, Kowalczyk JR, Whitlock JA, Zwaan CM. Buitenkamp TD, et al. Blood. 2014 Jan 2;123(1):70-7. doi: 10.1182/blood-2013-06-509463. Epub 2013 Nov 12. Blood. 2014. PMID: 24222333 Free PMC article.

DS-ALL patients had a higher 8-year cumulative incidence of relapse (26% 2% vs 15% 1%, P < .001) and 2-year treatment-related mortality (TRM) (7% 1% vs 2.0% <1%, P < .0001) than non-DS patients, resulting in lower 8-year event-free survival (EFS) (64% 2% vs

DS-ALL patients had a higher 8-year cumulative incidence of relapse (26% 2% vs 15% 1%, P < .001) and 2-year treatment-related mortalit

Surgical Treatment for Congenital Heart Defects in Down Syndrome Patients.
Santos FCGB, Croti UA, Marchi CH, Murakami AN, Brachine JDP, Borim BC, Finoti RG, Godoy MF. Santos FCGB, et al. Braz J Cardiovasc Surg. 2019 Jan-Feb;34(1):1-7. doi: 10.21470/1678-9741-2018-0358. Braz J Cardiovasc Surg. 2019. PMID: 30810666 Free PMC article.
The data included gender, age, prematurity, weight, preoperative procedures, diagnosis, associated cardiac and non-cardiac anomalies, Risk Adjustment for Congenital Heart Surgery (RACHS-1), type of surgery, cardiopulmonary bypass (CPB), perfusion time, aortic clamping time and CP …
The data included gender, age, prematurity, weight, preoperative procedures, diagnosis, associated cardiac and non-cardiac anomalies, Risk A …
Congenital heart defects associated with aneuploidy syndromes: New insights into familiar associations.
Lin AE, Santoro S, High FA, Goldenberg P, Gutmark-Little I. Lin AE, et al. Am J Med Genet C Semin Med Genet. 2020 Mar;184(1):53-63. doi: 10.1002/ajmg.c.31760. Epub 2019 Dec 23. Am J Med Genet C Semin Med Genet. 2020. PMID: 31868316
When detected prenatally, severe CHDs may influence decision-making, and postnatally, they are often the major determinants of survival. This review should be useful to geneticists, cardiologists, neonatologists, perinatal specialists, other pediatric specialists, and gene …
When detected prenatally, severe CHDs may influence decision-making, and postnatally, they are often the major determinants of survival
Down Syndrome and the Risk of Severe RSV Infection: A Meta-analysis.
Beckhaus AA, Castro-Rodriguez JA. Beckhaus AA, et al. Pediatrics. 2018 Sep;142(3):e20180225. doi: 10.1542/peds.2018-0225. Epub 2018 Aug 9. Pediatrics. 2018. PMID: 30093540 Free article.
The primary outcomes were hospital admission and mortality. Secondary outcomes included length of hospital stay, oxygen requirement, ICU admission, need for respiratory support, and additional medication use. ...DS was associated with a higher risk of hospitalization (odds …
The primary outcomes were hospital admission and mortality. Secondary outcomes included length of hospital stay, oxygen requirement, …
Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971.
Gamis AS, Alonzo TA, Gerbing RB, Hilden JM, Sorrell AD, Sharma M, Loew TW, Arceci RJ, Barnard D, Doyle J, Massey G, Perentesis J, Ravindranath Y, Taub J, Smith FO. Gamis AS, et al. Blood. 2011 Dec 22;118(26):6752-9; quiz 6996. doi: 10.1182/blood-2011-04-350017. Epub 2011 Aug 17. Blood. 2011. PMID: 21849481 Free PMC article. Clinical Trial.
On the basis of the diagnostic clinical findings of hepatomegaly with or without life-threatening symptoms, 3 groups were identified with differing survival: low risk with neither finding (38%), intermediate risk with hepatomegaly alone (40%), and high risk with both (21%; …
On the basis of the diagnostic clinical findings of hepatomegaly with or without life-threatening symptoms, 3 groups were identified with di …
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