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2003 1
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2019 4
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Page 1
Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.
Frau M, Feo F, Pascale RM. Frau M, et al. J Hepatol. 2013 Oct;59(4):830-41. doi: 10.1016/j.jhep.2013.04.031. Epub 2013 May 7. J Hepatol. 2013. PMID: 23665184 Free article. Review.
All of these changes are reversed by SAM treatment in vivo or forced MAT1A overexpression or MAT2A inhibition in cultured HCC cells. In human HCC, MAT1A:MAT2A and MATI/III:MATII ratios correlate negatively with cell proliferation and genomic instability, and positively wit …
All of these changes are reversed by SAM treatment in vivo or forced MAT1A overexpression or MAT2A inhibition in cultured HCC cells. In h
The neural ELAVL protein HuB enhances endogenous proto-oncogene activation.
Hatanaka T, Higashino F, Tei K, Yasuda M. Hatanaka T, et al. Biochem Biophys Res Commun. 2019 Sep 17;517(2):330-337. doi: 10.1016/j.bbrc.2019.07.089. Epub 2019 Jul 26. Biochem Biophys Res Commun. 2019. PMID: 31358321
The cytoplasmic distribution of the HuR/ELAVL1 (embryonic lethal abnormal vision 1) protein is recognized as an important prognostic factor of malignant tumors. ...Finally, co-transfection of HuB with the E1 region of type 5 human
The cytoplasmic distribution of the HuR/ELAVL1 (embryonic lethal abnormal vision 1) protein is rec …
Multifaceted roles of HSF1 in cancer.
Jiang S, Tu K, Fu Q, Schmitt DC, Zhou L, Lu N, Zhao Y. Jiang S, et al. Tumour Biol. 2015 Jul;36(7):4923-31. doi: 10.1007/s13277-015-3674-x. Epub 2015 Jun 25. Tumour Biol. 2015. PMID: 26108999 Review.
Accumulating evidence shows that HSF1 is overexpressed in a variety of human cancers, is associated with cancer aggressiveness, and could serve as an independent diagnostic or prognostic biomarker. ...Third, HSF1 serves as a regulator of different signaling pathways, such …
Accumulating evidence shows that HSF1 is overexpressed in a variety of human cancers, is associated with cancer aggressiveness, and c …
Pharmacological activities of dihydrotanshinone I, a natural product from Salvia miltiorrhiza Bunge.
Chen X, Yu J, Zhong B, Lu J, Lu JJ, Li S, Lu Y. Chen X, et al. Pharmacol Res. 2019 Jul;145:104254. doi: 10.1016/j.phrs.2019.104254. Epub 2019 May 1. Pharmacol Res. 2019. PMID: 31054311
Furthermore, several molecules such as hypoxia-inducible factor (HIF-1alpha), human antigen R (HuR), acetylcholinesterase (AchE), etc. have been identified as the potential targets for DHT. ...
Furthermore, several molecules such as hypoxia-inducible factor (HIF-1alpha), human antigen R (HuR), acet …
RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1alpha signaling in nucleus pulposus cells.
Pan H, Strickland A, Madhu V, Johnson ZI, Chand SN, Brody JR, Fertala A, Zheng Z, Shapiro IM, Risbud MV. Pan H, et al. Matrix Biol. 2019 Apr;77:23-40. doi: 10.1016/j.matbio.2018.08.003. Epub 2018 Aug 7. Matrix Biol. 2019. PMID: 30092282 Free PMC article.
HuR did not show cytoplasmic translocation in hypoxia and its silencing did not alter levels of Hif-1alpha or HIF-targets in NP cells. ...Interestingly, while HuR bound to Hif-1alpha and Vegf mRNAs, it was clear that compensatory mechanisms sust
HuR did not show cytoplasmic translocation in hypoxia and its silencing did not alter levels of Hif-1alpha or HIF-targe
Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma.
Tsai IT, Kuo CC, Liou JP, Chang JY. Tsai IT, et al. J Biomed Sci. 2018 Mar 28;25(1):28. doi: 10.1186/s12929-018-0432-6. J Biomed Sci. 2018. PMID: 29592811 Free PMC article.
We recently discovered a novel microtubule inhibitor, MPT0B098, that employs a novel antitumor mechanism. It destabilizes hypoxia-inducible factor (HIF)-1alpha mRNA by blocking the function of human antigen R. Thus, we proposed that MPT0B098 modulates …
We recently discovered a novel microtubule inhibitor, MPT0B098, that employs a novel antitumor mechanism. It destabilizes hypoxia-inducible …
Transcriptomic studies provide insights into the tumor suppressive role of miR-146a-5p in non-small cell lung cancer (NSCLC) cells.
Iacona JR, Monteleone NJ, Lemenze AD, Cornett AL, Lutz CS. Iacona JR, et al. RNA Biol. 2019 Dec;16(12):1721-1732. doi: 10.1080/15476286.2019.1657351. Epub 2019 Aug 23. RNA Biol. 2019. PMID: 31425002 Free PMC article.
Our transcriptomic data revealed that miR-146a-5p exerts its tumor suppressive function beyond previously reported targeting of EGFR and NF-kappaB signaling. miR-146a-5p mimic transfection downregulated arachidonic acid metabolism genes, the RNA-binding protein HuR, and ma …
Our transcriptomic data revealed that miR-146a-5p exerts its tumor suppressive function beyond previously reported targeting of EGFR and NF- …
HIF-inducible miR-191 promotes migration in breast cancer through complex regulation of TGFbeta-signaling in hypoxic microenvironment.
Nagpal N, Ahmad HM, Chameettachal S, Sundar D, Ghosh S, Kulshreshtha R. Nagpal N, et al. Sci Rep. 2015 Apr 13;5:9650. doi: 10.1038/srep09650. Sci Rep. 2015. PMID: 25867965 Free PMC article.
Our results show that hypoxia through hypoxia-inducible factor (HIF) brings about a time-dependent increase in the level of an oncogenic microRNA, miR-191 in various breast cancer cell lines. miR-191 enhances breast cancer aggressiveness by promoting cell proliferation, mi …
Our results show that hypoxia through hypoxia-inducible factor (HIF) brings about a time-dependent increase in the level of an oncoge …
Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair.
Mikhed Y, Görlach A, Knaus UG, Daiber A. Mikhed Y, et al. Redox Biol. 2015 Aug;5:275-289. doi: 10.1016/j.redox.2015.05.008. Epub 2015 Jun 3. Redox Biol. 2015. PMID: 26079210 Free PMC article. Review.
In addition, classical regulation of gene expression or activity, including gene transcription to RNA followed by translation to the protein level, by transcription factors (e.g. NF-kappaB, HIF-1alpha) and mRNA binding proteins (e.g. GAPDH, HuR) is subject to redox …
In addition, classical regulation of gene expression or activity, including gene transcription to RNA followed by translation to the protein …
MiR675-5p Acts on HIF-1alpha to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma.
Lo Dico A, Costa V, Martelli C, Diceglie C, Rajata F, Rizzo A, Mancone C, Tripodi M, Ottobrini L, Alessandro R, Conigliaro A. Lo Dico A, et al. Theranostics. 2016 May 8;6(8):1105-18. doi: 10.7150/thno.14700. eCollection 2016. Theranostics. 2016. PMID: 27279905 Free PMC article.
We demonstrated, in vitro and in vivo, that miR675-5p over expression in normoxia is sufficient to induce a hypoxic moreover, miR675-5p depletion in low oxygen conditions, drastically abolishes hypoxic responses including angiogenesis. In addition, our data indicate an interactio …
We demonstrated, in vitro and in vivo, that miR675-5p over expression in normoxia is sufficient to induce a hypoxic moreover, miR675-5p depl …
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