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Year Number of Results
2003 1
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2005 1
2007 1
2008 4
2009 2
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2011 1
2012 2
2013 2
2014 2
2015 3
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2018 2
2019 4
2020 1
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Page 1
Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.
Frau M, Feo F, Pascale RM. Frau M, et al. J Hepatol. 2013 Oct;59(4):830-41. doi: 10.1016/j.jhep.2013.04.031. Epub 2013 May 7. J Hepatol. 2013. PMID: 23665184 Free article. Review.
In human HCC, MAT1A:MAT2A and MATI/III:MATII ratios correlate negatively with cell proliferation and genomic instability, and positively with apoptosis and global DNA methylation. ...Finally, MATI/III:MATII ratio strongly predicts patients' survival length suggesting that …
In human HCC, MAT1A:MAT2A and MATI/III:MATII ratios correlate negatively with cell proliferation and genomic instability, and positiv …
The neural ELAVL protein HuB enhances endogenous proto-oncogene activation.
Hatanaka T, Higashino F, Tei K, Yasuda M. Hatanaka T, et al. Biochem Biophys Res Commun. 2019 Sep 17;517(2):330-337. doi: 10.1016/j.bbrc.2019.07.089. Epub 2019 Jul 26. Biochem Biophys Res Commun. 2019. PMID: 31358321
The cytoplasmic distribution of the HuR/ELAVL1 (embryonic lethal abnormal vision 1) protein is recognized as an important prognostic factor of malignant tumors. ...Finally, co-transfection of HuB with the E1 region of type 5 human
The cytoplasmic distribution of the HuR/ELAVL1 (embryonic lethal abnormal vision 1) protein is rec …
RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells.
Pan H, Strickland A, Madhu V, Johnson ZI, Chand SN, Brody JR, Fertala A, Zheng Z, Shapiro IM, Risbud MV. Pan H, et al. Matrix Biol. 2019 Apr;77:23-40. doi: 10.1016/j.matbio.2018.08.003. Epub 2018 Aug 7. Matrix Biol. 2019. PMID: 30092282 Free PMC article.
HuR did not show cytoplasmic translocation in hypoxia and its silencing did not alter levels of Hif-1α or HIF-targets in NP cells. ...In addition, messenger ribonucleoprotein immunoprecipitation demonstrated HuR binding to Tgf-β3 and Sdc4 mRNAs. Intere
HuR did not show cytoplasmic translocation in hypoxia and its silencing did not alter levels of Hif-1α or HIF-targets i
Transcriptomic studies provide insights into the tumor suppressive role of miR-146a-5p in non-small cell lung cancer (NSCLC) cells.
Iacona JR, Monteleone NJ, Lemenze AD, Cornett AL, Lutz CS. Iacona JR, et al. RNA Biol. 2019 Dec;16(12):1721-1732. doi: 10.1080/15476286.2019.1657351. Epub 2019 Aug 23. RNA Biol. 2019. PMID: 31425002 Free PMC article.
Our transcriptomic data revealed that miR-146a-5p exerts its tumor suppressive function beyond previously reported targeting of EGFR and NF-κB signaling. miR-146a-5p mimic transfection downregulated arachidonic acid metabolism genes, the RNA-binding protein HuR, and many …
Our transcriptomic data revealed that miR-146a-5p exerts its tumor suppressive function beyond previously reported targeting of EGFR and NF- …
Pharmacological activities of dihydrotanshinone I, a natural product from Salvia miltiorrhiza Bunge.
Chen X, Yu J, Zhong B, Lu J, Lu JJ, Li S, Lu Y. Chen X, et al. Pharmacol Res. 2019 Jul;145:104254. doi: 10.1016/j.phrs.2019.104254. Epub 2019 May 1. Pharmacol Res. 2019. PMID: 31054311
Furthermore, several molecules such as hypoxia-inducible factor (HIF-1α), human antigen R (HuR), acetylcholinesterase (AchE), etc. have been identified as the potential targets for DHT. ...
Furthermore, several molecules such as hypoxia-inducible factor (HIF-1α), human antigen R (HuR), acetylch …
Androgens regulate the binding of endogenous HuR to the AU-rich 3'UTRs of HIF-1alpha and EGF mRNA.
Sheflin LG, Zou AP, Spaulding SW. Sheflin LG, et al. Biochem Biophys Res Commun. 2004 Sep 17;322(2):644-51. doi: 10.1016/j.bbrc.2004.07.173. Biochem Biophys Res Commun. 2004. PMID: 15325278
Androgens regulate the level and subcellular shuttling of HuR, a major ARE-binding protein that stabilizes many ARE-mRNAs. Pull down of biotinylated 3'UTRs of HIF-1alpha or EGF enriches HuR on blots from Jurkat cell lysates 5-fold, and enriches the amount of …
Androgens regulate the level and subcellular shuttling of HuR, a major ARE-binding protein that stabilizes many ARE-mRNAs. Pull down …
Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1.
Tong X, Mirzoeva S, Veliceasa D, Bridgeman BB, Fitchev P, Cornwell ML, Crawford SE, Pelling JC, Volpert OV. Tong X, et al. Oncotarget. 2014 Nov 30;5(22):11413-27. doi: 10.18632/oncotarget.2551. Oncotarget. 2014. PMID: 25526033 Free PMC article.
Cox-2 and HIF-1α are important mediators of angiogenesis. Both apigenin and TSP1 peptide mimetic attenuated their induction by UVB. ...Knockdown studies implicated the RNA-binding protein HuR, which controls mRNA stability and translation. Apigenin increased HuR
Cox-2 and HIF-1α are important mediators of angiogenesis. Both apigenin and TSP1 peptide mimetic attenuated their induction by UVB. . …
Multifaceted roles of HSF1 in cancer.
Jiang S, Tu K, Fu Q, Schmitt DC, Zhou L, Lu N, Zhao Y. Jiang S, et al. Tumour Biol. 2015 Jul;36(7):4923-31. doi: 10.1007/s13277-015-3674-x. Epub 2015 Jun 25. Tumour Biol. 2015. PMID: 26108999 Review.
Accumulating evidence shows that HSF1 is overexpressed in a variety of human cancers, is associated with cancer aggressiveness, and could serve as an independent diagnostic or prognostic biomarker. ...Third, HSF1 serves as a regulator of different signaling pathways, such …
Accumulating evidence shows that HSF1 is overexpressed in a variety of human cancers, is associated with cancer aggressiveness, and c …
Expression of vascular endothelial growth factor-A and mRNA stability factor HuR in human astrocytic tumors.
Ido K, Nakagawa T, Sakuma T, Takeuchi H, Sato K, Kubota T. Ido K, et al. Neuropathology. 2008 Dec;28(6):604-11. doi: 10.1111/j.1440-1789.2008.00926.x. Epub 2008 May 21. Neuropathology. 2008. PMID: 18498284
While the former mechanism mediated by hypoxia inducible factor-1 alpha (HIF-1alpha) has been revealed, the latter mediated by mRNA stability factor HuR remains unclear in astrocytic tumors. ...These findings suggest that the expression of VEGF-A and cytoplasmic tra …
While the former mechanism mediated by hypoxia inducible factor-1 alpha (HIF-1alpha) has been revealed, the latter mediated by mRNA s …
Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma.
Tsai IT, Kuo CC, Liou JP, Chang JY. Tsai IT, et al. J Biomed Sci. 2018 Mar 28;25(1):28. doi: 10.1186/s12929-018-0432-6. J Biomed Sci. 2018. PMID: 29592811 Free PMC article.
It destabilizes hypoxia-inducible factor (HIF)-1α mRNA by blocking the function of human antigen R. Thus, we proposed that MPT0B098 modulates hypoxia-induced EMT. ...RESULTS: MPT0B098 significantly inhibited HIF-1α expression, epithelial-to-mese …
It destabilizes hypoxia-inducible factor (HIF)-1α mRNA by blocking the function of human antigen R. Thus, we pro …
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