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MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1.
Jeyabal P, Thandavarayan RA, Joladarashi D, Suresh Babu S, Krishnamurthy S, Bhimaraj A, Youker KA, Kishore R, Krishnamurthy P. Jeyabal P, et al. Biochem Biophys Res Commun. 2016 Mar 18;471(4):423-9. doi: 10.1016/j.bbrc.2016.02.065. Epub 2016 Feb 17. Biochem Biophys Res Commun. 2016. PMID: 26898797 Free PMC article.
ELAV-like protein 1 (ELAVL1) plays a critical role in the progression of inflammation and HF. However the role of ELAVL-1 in inflammation induced cardiac cell death (pyroptosis) under hyperglycemic condition remains elusive. Our data demonstrates that …
ELAV-like protein 1 (ELAVL1) plays a critical role in the progression of inflammation and HF. However the role of ELAVL …
HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts.
Di Mari JF, Saada JI, Mifflin RC, Valentich JD, Powell DW. Di Mari JF, et al. Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G719-28. doi: 10.1152/ajpgi.00117.2007. Epub 2007 Jul 19. Am J Physiol Gastrointest Liver Physiol. 2007. PMID: 17640979 Free article.
We have previously demonstrated that IL-1alpha-induced cyclooxygenase-2 (COX-2) expression is the result of NF-kappaB- and ERK-mediated transcription, as well as COX-2 message stabilization, which depends on p38, MAPKAPK-2 (MK-2) and human antigen R ( …
We have previously demonstrated that IL-1alpha-induced cyclooxygenase-2 (COX-2) expression is the result of NF-kappaB- and ERK-mediat …
RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment.
Yeh CH, Hung LY, Hsu C, Le SY, Lee PT, Liao WL, Lin YT, Chang WC, Tseng JT. Yeh CH, et al. Mol Biol Cell. 2008 Sep;19(9):3812-22. doi: 10.1091/mbc.e07-09-0962. Epub 2008 Jun 25. Mol Biol Cell. 2008. PMID: 18579691 Free PMC article.
When cells were treated with IL-1beta, the IRES activity was suppressed and accompanied by an increased interaction between HuR and TM 5'UTR. ...In summary, HuR plays an important role in suppression of TM protein synthesis in IL-1beta treatment and se …
When cells were treated with IL-1beta, the IRES activity was suppressed and accompanied by an increased interaction between HuR
Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-alpha and beta and tumor necrosis factor-alpha and beta.
Duncan MR, Berman B. Duncan MR, et al. J Invest Dermatol. 1989 May;92(5):699-706. doi: 10.1111/1523-1747.ep12696891. J Invest Dermatol. 1989. PMID: 2541208 Free article.
In order to clarify the role played by immunologically derived cytokines in dermal connective tissue synthesis and degradation, we investigated the effect of human recombinant (hu-r) interleukin (IL) 1-alpha and beta, hu-r tumor necrosis factor …
In order to clarify the role played by immunologically derived cytokines in dermal connective tissue synthesis and degradation, we investiga …
Interleukin 1β Regulation of the System xc- Substrate-specific Subunit, xCT, in Primary Mouse Astrocytes Involves the RNA-binding Protein HuR.
Shi J, He Y, Hewett SJ, Hewett JA. Shi J, et al. J Biol Chem. 2016 Jan 22;291(4):1643-51. doi: 10.1074/jbc.M115.697821. Epub 2015 Nov 24. J Biol Chem. 2016. PMID: 26601945 Free PMC article.
Additionally, IL-1β induces HuR translocation from the nucleus to the cytoplasm. RNA immunoprecipitation analysis reveals that HuR binds directly to the 3'-UTR of xCT in an IL-1β-dependent manner. ...Altogether, these data support a critical role for …
Additionally, IL-1β induces HuR translocation from the nucleus to the cytoplasm. RNA immunoprecipitation analysis reveals that …
ATP potentiates interleukin-1 beta-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR.
Huwiler A, Akool el-S, Aschrafi A, Hamada FM, Pfeilschifter J, Eberhardt W. Huwiler A, et al. J Biol Chem. 2003 Dec 19;278(51):51758-69. doi: 10.1074/jbc.M305722200. Epub 2003 Oct 1. J Biol Chem. 2003. PMID: 14523003 Free article.
Renal mesangial cells express high levels of matrix metalloproteinase 9 (MMP-9) in response to inflammatory cytokines such as interleukin (IL)-1 beta. ...Mutation of each ARE element strongly impaired the RNA binding of the HuR containing complexes. Reporter …
Renal mesangial cells express high levels of matrix metalloproteinase 9 (MMP-9) in response to inflammatory cytokines such as interleukin ( …
Interleukin-1/toll-like receptor-induced nuclear factor kappa B signaling participates in intima hyperplasia after carotid artery balloon injury in goto-kakizaki rats: a potential target therapy pathway.
Zhang X, Wang Y, Hu W, Li D, Zhou Z, Pan D, Wu W, Xu T. Zhang X, et al. PLoS One. 2014 Aug 1;9(8):e103794. doi: 10.1371/journal.pone.0103794. eCollection 2014. PLoS One. 2014. PMID: 25083789 Free PMC article.
Interleukin-1/Toll-like receptor (IL-1/TLR) signaling is involved in innate and adaptive immune responses, but whether and how the IL-1/TLR-induced nuclear factor kappa B (NFκB) pathway plays key roles in intimal formation is unclear. ... …
Interleukin-1/Toll-like receptor (IL-1/TLR) signaling is involved in innate and adaptive immune responses, but w …
Radiation protection and restoration by the synthetic 163-171 nonapeptide of human interleukin 1 beta.
Frasca D, Baschieri S, Boraschi D, Tagliabue A, Doria G. Frasca D, et al. Radiat Res. 1991 Oct;128(1):43-7. Radiat Res. 1991. PMID: 1924727
We have previously reported that the synthetic nonapeptide VQGEESNDK, position 163-171 of human interleukin 1 (IL-1 beta), when injected in immunodepressed mice, shows immunorestorative activity similar to that of the whole protein, but with no IL
We have previously reported that the synthetic nonapeptide VQGEESNDK, position 163-171 of human interleukin 1 (IL-1
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