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Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression.
Chen J, Adamiak W, Huang G, Atasoy U, Rostami A, Yu S. Chen J, et al. Sci Rep. 2017 Dec 8;7(1):17233. doi: 10.1038/s41598-017-17371-5. Sci Rep. 2017. PMID: 29222492 Free PMC article.
The RNA-binding protein HuR functions to promote the stability of target mRNAs via binding the AU-rich elements of the 3' untranslated region (3'UTR) of numerous pro-inflammatory cytokines including IL-4, IL-13, IL-17 and TNF-α. ...Interestingly …
The RNA-binding protein HuR functions to promote the stability of target mRNAs via binding the AU-rich elements of the 3' untranslate …
Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis.
Chen J, Cascio J, Magee JD, Techasintana P, Gubin MM, Dahm GM, Calaluce R, Yu S, Atasoy U. Chen J, et al. J Immunol. 2013 Dec 1;191(11):5441-50. doi: 10.4049/jimmunol.1301188. Epub 2013 Oct 28. J Immunol. 2013. PMID: 24166976 Free PMC article.
The RNA-binding protein HuR positively regulates the stability of many target mRNAs via binding the AU-rich elements present in the 3' untranslated region of many inflammatory cytokines including IL-4, IL-13, and TNF-α. However, the regulation of IL
The RNA-binding protein HuR positively regulates the stability of many target mRNAs via binding the AU-rich elements present in the 3 …
Posttranscriptional regulation of IL-13 in T cells: role of the RNA-binding protein HuR.
Casolaro V, Fang X, Tancowny B, Fan J, Wu F, Srikantan S, Asaki SY, De Fanis U, Huang SK, Gorospe M, Atasoy UX, Stellato C. Casolaro V, et al. J Allergy Clin Immunol. 2008 Apr;121(4):853-9.e4. doi: 10.1016/j.jaci.2007.12.1166. Epub 2008 Feb 14. J Allergy Clin Immunol. 2008. PMID: 18279945 Free PMC article.
METHODS: IL-13 mRNA decay was monitored in human T(H)2-skewed cells by using the transcriptional inhibitor actinomycin D. The IL-13 3'UTR was subcloned into an inducible beta-globin reporter transiently expressed in H2 cells in the absence or pr …
METHODS: IL-13 mRNA decay was monitored in human T(H)2-skewed cells by using the transcriptional inhibitor actinomycin …
Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR.
Stellato C, Gubin MM, Magee JD, Fang X, Fan J, Tartar DM, Chen J, Dahm GM, Calaluce R, Mori F, Jackson GA, Casolaro V, Franklin CL, Atasoy U. Stellato C, et al. J Immunol. 2011 Jul 1;187(1):441-9. doi: 10.4049/jimmunol.1001881. Epub 2011 May 25. J Immunol. 2011. PMID: 21613615 Free PMC article.
The RBP HuR posttranscriptionally regulates IL-4, IL-13, and other Th2 cell-restricted transcripts. We hypothesized that the ARE-bearing GATA-3 gene, a critical regulator of Th2 polarization, is under HuR control as part of its coordinate posttr …
The RBP HuR posttranscriptionally regulates IL-4, IL-13, and other Th2 cell-restricted transcripts. We hypothesi …
Conditional knockout of the RNA-binding protein HuR in CD4⁺ T cells reveals a gene dosage effect on cytokine production.
Gubin MM, Techasintana P, Magee JD, Dahm GM, Calaluce R, Martindale JL, Whitney MS, Franklin CL, Besch-Williford C, Hollingsworth JW, Abdelmohsen K, Gorospe M, Atasoy U. Gubin MM, et al. Mol Med. 2014 Mar 20;20(1):93-108. doi: 10.2119/molmed.2013.00127. Mol Med. 2014. PMID: 24477678 Free PMC article.
The RBP HuR binds to labile mRNAs, usually leading to increases in mRNA stability and/or translation. Previous work demonstrated that HuR binds to the mRNAs encoding the Th2 transcription factor trans-acting T-cell-specific transcription factor (GATA-3) and Th2 cyto …
The RBP HuR binds to labile mRNAs, usually leading to increases in mRNA stability and/or translation. Previous work demonstrated that …
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