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The RNA-Binding Protein HuR Posttranscriptionally Regulates IL-2 Homeostasis and CD4(+) Th2 Differentiation.
Techasintana P, Ellis JS, Glascock J, Gubin MM, Ridenhour SE, Magee JD, Hart ML, Yao P, Zhou H, Whitney MS, Franklin CL, Martindale JL, Gorospe M, Davis WJ, Fox PL, Li X, Atasoy U. Techasintana P, et al. Immunohorizons. 2017 Aug 1;1(6):109-123. doi: 10.4049/immunohorizons.1700017. Immunohorizons. 2017. PMID: 30035254 Free PMC article.
It was previously demonstrated that HuR facilitates Th2 cytokine expression by mRNA stabilization. However, its effects upon IL-2 homeostasis and CD4(+) Th2 differentiation are not as well understood. ...HuR-knockout CD4(+) T cells from OVA-immunized m …
It was previously demonstrated that HuR facilitates Th2 cytokine expression by mRNA stabilization. However, its effects upon IL
HuR controls apoptosis and activation response without effects on cytokine 3' UTRs.
Karginov FV. Karginov FV. RNA Biol. 2019 May;16(5):686-695. doi: 10.1080/15476286.2019.1582954. Epub 2019 Mar 4. RNA Biol. 2019. PMID: 30777501 Free PMC article.
The broadly expressed HuR/ELAVL1 is important for proper function of multiple immune cell types, and has been proposed to regulate cytokine and other mRNA 3' UTRs upon activation. ...Knockout cells showed a significant defect in IL-2 production, which …
The broadly expressed HuR/ELAVL1 is important for proper function of multiple immune cell types, and has been proposed to regu …
The role of cytokine mRNA stability in the pathogenesis of autoimmune disease.
Seko Y, Cole S, Kasprzak W, Shapiro BA, Ragheb JA. Seko Y, et al. Autoimmun Rev. 2006 May;5(5):299-305. doi: 10.1016/j.autrev.2005.10.013. Epub 2005 Dec 21. Autoimmun Rev. 2006. PMID: 16782553 Review.
Inflammatory cytokines such as interferon (IFN)-gamma, interleukin (IL)-2, tumor-necrosis factor (TNF)-alpha and IL-17 play an important role in the pathogenesis of cell-mediated autoimmune diseases. ...Distinct cis- and trans-acting elements in human
Inflammatory cytokines such as interferon (IFN)-gamma, interleukin (IL)-2, tumor-necrosis factor (TNF)-alpha and IL-17 …
ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation.
Atasoy U, Watson J, Patel D, Keene JD. Atasoy U, et al. J Cell Sci. 1998 Nov;111 ( Pt 21):3145-56. J Cell Sci. 1998. PMID: 9763509 Free article.
ELAV proteins are implicated in regulating the stability and translation of cytokine and growth regulatory mRNAs such as GM-CSF, IL-2, c-myc, c-fos and GLUT1 by binding to their AU-rich 3'UTRs. ...Therefore, much like the primarily cytoplasmic HuB, HuA become …
ELAV proteins are implicated in regulating the stability and translation of cytokine and growth regulatory mRNAs such as GM-CSF, IL- …
Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-alpha and beta and tumor necrosis factor-alpha and beta.
Duncan MR, Berman B. Duncan MR, et al. J Invest Dermatol. 1989 May;92(5):699-706. doi: 10.1111/1523-1747.ep12696891. J Invest Dermatol. 1989. PMID: 2541208 Free article.
In order to clarify the role played by immunologically derived cytokines in dermal connective tissue synthesis and degradation, we investigated the effect of human recombinant (hu-r) interleukin (IL) 1-alpha and beta, hu-r tumor necrosis factor (TNF)-a …
In order to clarify the role played by immunologically derived cytokines in dermal connective tissue synthesis and degradation, we investiga …
mRNA openers and closers: modulating AU-rich element-controlled mRNA stability by a molecular switch in mRNA secondary structure.
Meisner NC, Hackermüller J, Uhl V, Aszódi A, Jaritz M, Auer M. Meisner NC, et al. Chembiochem. 2004 Oct 4;5(10):1432-47. doi: 10.1002/cbic.200400219. Chembiochem. 2004. PMID: 15457527
Thereby they increase in vitro and endogenous HuR-mRNA complex formation which leads to specific mRNA stabilization (as demonstrated for TNFalpha and IL-2, respectively). Induced HuR binding both inside and outside the AU-rich element promotes function …
Thereby they increase in vitro and endogenous HuR-mRNA complex formation which leads to specific mRNA stabilization (as demonstrated …
Effects of recombinant interleukin-2 and revaccination for hepatitis B in previously vaccinated, non-responder, chronic uraemic patients. Collaborative Group of Girona.
Mauri JM, Vallès M. Mauri JM, et al. Nephrol Dial Transplant. 1997 Apr;12(4):729-32. doi: 10.1093/ndt/12.4.729. Nephrol Dial Transplant. 1997. PMID: 9141002 Clinical Trial.
BACKGROUND: Growing evidence suggests that it is possible to seroconvert chronic renal failure patients who are absolute non-responders to hepatitis B vaccine by means of either additional booster vaccine doses or associated IL-2 administration or both. ...When comp …
BACKGROUND: Growing evidence suggests that it is possible to seroconvert chronic renal failure patients who are absolute non-responders to h …
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