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The role of HuR in the post-transcriptional regulation of interleukin-3 in T cells.
González-Feliciano JA, Hernández-Pérez M, Estrella LA, Colón-López DD, López A, Martínez M, Maurás-Rivera KR, Lasalde C, Martínez D, Araujo-Pérez F, González CI. González-Feliciano JA, et al. PLoS One. 2014 Mar 21;9(3):e92457. doi: 10.1371/journal.pone.0092457. eCollection 2014. PLoS One. 2014. PMID: 24658545 Free PMC article.
Human Interleukin-3 (IL-3) is a lymphokine member of a class of transiently expressed mRNAs harboring Adenosine/Uridine-Rich Elements (ARE) in their 3' untranslated regions (3'-UTRs). ...In this report, we show that the human IL
Human Interleukin-3 (IL-3) is a lymphokine member of a class of transiently expressed mRNAs harboring Adenosine/
LFA-1-dependent HuR nuclear export and cytokine mRNA stabilization in T cell activation.
Wang JG, Collinge M, Ramgolam V, Ayalon O, Fan XC, Pardi R, Bender JR. Wang JG, et al. J Immunol. 2006 Feb 15;176(4):2105-13. doi: 10.4049/jimmunol.176.4.2105. J Immunol. 2006. PMID: 16455966 Free article.
In this study we demonstrate that engagement of the beta(2) integrin LFA-1 in human peripheral T cells markedly extends the half-life of TNF-alpha, GM-CSF, and IL-3 mRNA, as well as a chimeric beta-globin mRNA reporter construct containing a strongly destabil …
In this study we demonstrate that engagement of the beta(2) integrin LFA-1 in human peripheral T cells markedly extends the half-life …
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