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Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression.
Chen J, Adamiak W, Huang G, Atasoy U, Rostami A, Yu S. Chen J, et al. Sci Rep. 2017 Dec 8;7(1):17233. doi: 10.1038/s41598-017-17371-5. Sci Rep. 2017. PMID: 29222492 Free PMC article.
The RNA-binding protein HuR functions to promote the stability of target mRNAs via binding the AU-rich elements of the 3' untranslated region (3'UTR) of numerous pro-inflammatory cytokines including IL-4, IL-13, IL-17 and TNF-α. ...Interestingly …
The RNA-binding protein HuR functions to promote the stability of target mRNAs via binding the AU-rich elements of the 3' untranslate …
Interleukin-4-induced posttranscriptional gene regulation of CCL26 by the RNA-binding protein HuR in primary human nasal polyp-derived epithelial cells.
Tian P, Ou H, Wu F, Ma Y, Liu X, Chen Q, Dang H, Zou H. Tian P, et al. Int Forum Allergy Rhinol. 2019 Mar;9(3):311-321. doi: 10.1002/alr.22250. Epub 2018 Nov 24. Int Forum Allergy Rhinol. 2019. PMID: 30472791 Clinical Trial.
The aim of this study was to characterize CCL26 posttranscriptional regulation by the RNA-binding protein HuR in primary human nasal polyp-derived epithelial cells (hNPDECs) challenged with IL-4. ...IL-4 stimulation increased CCL26 mRNA s …
The aim of this study was to characterize CCL26 posttranscriptional regulation by the RNA-binding protein HuR in primary human
Early exposure to IL-4 stabilizes IL-4 mRNA in CD4+ T cells via RNA-binding protein HuR.
Yarovinsky TO, Butler NS, Monick MM, Hunninghake GW. Yarovinsky TO, et al. J Immunol. 2006 Oct 1;177(7):4426-35. doi: 10.4049/jimmunol.177.7.4426. J Immunol. 2006. PMID: 16982877 Free article.
This effect of IL-4 was mediated by the RNA-binding protein HuR. IL-4 mRNA interacted with HuR and the dominant binding site was shown within the coding region of IL-4 mRNA. Exposure of CD4+ T cells to IL-4 had …
This effect of IL-4 was mediated by the RNA-binding protein HuR. IL-4 mRNA interacted with HuR and …
Regulation of eotaxin gene expression by TNF-alpha and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR.
Atasoy U, Curry SL, López de Silanes I, Shyu AB, Casolaro V, Gorospe M, Stellato C. Atasoy U, et al. J Immunol. 2003 Oct 15;171(8):4369-78. doi: 10.4049/jimmunol.171.8.4369. J Immunol. 2003. PMID: 14530362 Free article.
The half-life of the chimeric mRNA was markedly increased in cells stimulated with TNF-alpha and IL-4. Evidence that the mRNA-stabilizing protein HuR participated in the cytokine effect was obtained: first, HuR presence in the cytoplasm, believed to be …
The half-life of the chimeric mRNA was markedly increased in cells stimulated with TNF-alpha and IL-4. Evidence that the mRNA- …
Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis.
Chen J, Cascio J, Magee JD, Techasintana P, Gubin MM, Dahm GM, Calaluce R, Yu S, Atasoy U. Chen J, et al. J Immunol. 2013 Dec 1;191(11):5441-50. doi: 10.4049/jimmunol.1301188. Epub 2013 Oct 28. J Immunol. 2013. PMID: 24166976 Free PMC article.
The RNA-binding protein HuR positively regulates the stability of many target mRNAs via binding the AU-rich elements present in the 3' untranslated region of many inflammatory cytokines including IL-4, IL-13, and TNF-α. However, the regulation of IL
The RNA-binding protein HuR positively regulates the stability of many target mRNAs via binding the AU-rich elements present in the 3 …
Conditional knockout of the RNA-binding protein HuR in CD4⁺ T cells reveals a gene dosage effect on cytokine production.
Gubin MM, Techasintana P, Magee JD, Dahm GM, Calaluce R, Martindale JL, Whitney MS, Franklin CL, Besch-Williford C, Hollingsworth JW, Abdelmohsen K, Gorospe M, Atasoy U. Gubin MM, et al. Mol Med. 2014 Mar 20;20(1):93-108. doi: 10.2119/molmed.2013.00127. Mol Med. 2014. PMID: 24477678 Free PMC article.
The RBP HuR binds to labile mRNAs, usually leading to increases in mRNA stability and/or translation. Previous work demonstrated that HuR binds to the mRNAs encoding the Th2 transcription factor trans-acting T-cell-specific transcription factor (GATA-3) and Th2 cyto …
The RBP HuR binds to labile mRNAs, usually leading to increases in mRNA stability and/or translation. Previous work demonstrated that …
Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR.
Stellato C, Gubin MM, Magee JD, Fang X, Fan J, Tartar DM, Chen J, Dahm GM, Calaluce R, Mori F, Jackson GA, Casolaro V, Franklin CL, Atasoy U. Stellato C, et al. J Immunol. 2011 Jul 1;187(1):441-9. doi: 10.4049/jimmunol.1001881. Epub 2011 May 25. J Immunol. 2011. PMID: 21613615 Free PMC article.
The RBP HuR posttranscriptionally regulates IL-4, IL-13, and other Th2 cell-restricted transcripts. We hypothesized that the ARE-bearing GATA-3 gene, a critical regulator of Th2 polarization, is under HuR control as part of its coordinate posttr …
The RBP HuR posttranscriptionally regulates IL-4, IL-13, and other Th2 cell-restricted transcripts. We hypothesi …
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