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Year Number of Results
2001 1
2005 1
2007 1
2008 1
2009 2
2010 1
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2012 3
2013 5
2014 4
2015 4
2017 6
2018 3
2019 1
2020 0
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Page 1
The induced RNA-binding protein, HuR, targets 3'-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis.
Ouhara K, Munenaga S, Kajiya M, Takeda K, Matsuda S, Sato Y, Hamamoto Y, Iwata T, Yamasaki S, Akutagawa K, Mizuno N, Fujita T, Sugiyama E, Kurihara H. Ouhara K, et al. Clin Exp Immunol. 2018 Jun;192(3):325-336. doi: 10.1111/cei.13110. Epub 2018 Mar 8. Clin Exp Immunol. 2018. PMID: 29393507 Free PMC article.
Human antigen-R (HuR), one of the RBPs, is involved in the progression of diseases, such as rheumatoid arthritis, diabetes mellitus and some inflammatory diseases. ...These results show that HuR modulates inflammatory responses by regulating
Human antigen-R (HuR), one of the RBPs, is involved in the progression of diseases, such as rheumatoid arthritis
Progress on the relationship between miR-125 family and tumorigenesis.
Yin H, Sun Y, Wang X, Park J, Zhang Y, Li M, Yin J, Liu Q, Wei M. Yin H, et al. Exp Cell Res. 2015 Dec 10;339(2):252-60. doi: 10.1016/j.yexcr.2015.09.015. Epub 2015 Sep 25. Exp Cell Res. 2015. PMID: 26407906 Review.
The downstream targets of miRNA-125 include transcription factors like STAT3, cytokines like IL-6 and TGF-β, tumor suppressing protein p53, pro-apoptotic protein Bak1 and RNA binding protein HuR et al. ...
The downstream targets of miRNA-125 include transcription factors like STAT3, cytokines like IL-6 and TGF-β, tum …
APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells.
Li S, Bao X, Wang D, You L, Li X, Yang H, Bian J, Wang Y, Yang Y. Li S, et al. Sci China Life Sci. 2017 Jun;60(6):617-626. doi: 10.1007/s11427-016-9058-6. Epub 2017 May 29. Sci China Life Sci. 2017. PMID: 28646470
It has been confirmed that interleukin-6 (IL-6) has significant impacts on oncogenesis of HCC. Here, we reported that the expression of IL-6 was substantially up-regulated by A3B in HepG2 cells. A3B induced IL-6 expression through …
It has been confirmed that interleukin-6 (IL-6) has significant impacts on oncogenesis of HCC. Here, we reported that t …
Apigenin Inhibits UVB-Induced Skin Carcinogenesis: The Role of Thrombospondin-1 as an Anti-Inflammatory Factor.
Mirzoeva S, Tong X, Bridgeman BB, Plebanek MP, Volpert OV. Mirzoeva S, et al. Neoplasia. 2018 Sep;20(9):930-942. doi: 10.1016/j.neo.2018.07.005. Epub 2018 Aug 15. Neoplasia. 2018. PMID: 30118999 Free PMC article.
We have previously demonstrated that apigenin promotes the expression of antiangiogenic protein thrombospondin-1 (TSP1) via a mechanism driven by mRNA-binding protein HuR. ...Importantly, TKO mice presented with the elevated cutaneous inflammation at baseline, which was ma …
We have previously demonstrated that apigenin promotes the expression of antiangiogenic protein thrombospondin-1 (TSP1) via a mechanism driv …
The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cells.
Gurgis FM, Yeung YT, Tang MX, Heng B, Buckland M, Ammit AJ, Haapasalo J, Haapasalo H, Guillemin GJ, Grewal T, Munoz L. Gurgis FM, et al. Oncogene. 2015 May 28;34(22):2934-42. doi: 10.1038/onc.2014.225. Epub 2014 Aug 4. Oncogene. 2015. PMID: 25088200
Enhanced IL-6 production and increased sensitivity toward pharmacological p38 MAPK and MK2 inhibitors in EGFRvIII-expressing GBM cells is associated with increased MK2-dependent nuclear-cytoplasmic shuttling and accumulation of human antigen R ( …
Enhanced IL-6 production and increased sensitivity toward pharmacological p38 MAPK and MK2 inhibitors in EGFRvIII-expressing G …
HIV protease inhibitor lopinavir-induced TNF-alpha and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages.
Chen L, Jarujaron S, Wu X, Sun L, Zha W, Liang G, Wang X, Gurley EC, Studer EJ, Hylemon PB, Pandak WM Jr, Zhang L, Wang G, Li X, Dent P, Zhou H. Chen L, et al. Biochem Pharmacol. 2009 Jul 1;78(1):70-7. doi: 10.1016/j.bcp.2009.03.022. Epub 2009 Mar 31. Biochem Pharmacol. 2009. PMID: 19447225 Free PMC article.
We have previously shown that HIV PIs induce endoplasmic reticulum (ER) stress, activate the unfolded protein response (UPR), and increase the synthesis of the inflammatory cytokines, TNF-alpha and IL-6, by regulating the intracellular translocation of RNA binding p …
We have previously shown that HIV PIs induce endoplasmic reticulum (ER) stress, activate the unfolded protein response (UPR), and increase t …
HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuR.
Zhou H, Jarujaron S, Gurley EC, Chen L, Ding H, Studer E, Pandak WM Jr, Hu W, Zou T, Wang JY, Hylemon PB. Zhou H, et al. Atherosclerosis. 2007 Nov;195(1):e134-43. doi: 10.1016/j.atherosclerosis.2007.04.008. Epub 2007 May 24. Atherosclerosis. 2007. PMID: 17531241
Furthermore, we show that the RNA-binding protein, HuR, plays an important role in HIV PI-induced expression of TNF-alpha and IL-6. Atazanavir increased the cytoplasmic levels of HuR and enhanced the binding of HuR to 3'-UTR of TNF-alpha and …
Furthermore, we show that the RNA-binding protein, HuR, plays an important role in HIV PI-induced expression of TNF-alpha and IL
A balancing act: RNA binding protein HuR/TTP axis in endometriosis patients.
Khalaj K, Ahn SH, Bidarimath M, Nasirzadeh Y, Singh SS, Fazleabas AT, Young SL, Lessey BA, Koti M, Tayade C. Khalaj K, et al. Sci Rep. 2017 Jul 19;7(1):5883. doi: 10.1038/s41598-017-06081-7. Sci Rep. 2017. PMID: 28724967 Free PMC article.
Human antigen R (HuR) and Tristetraprolin (TTP) are RNA binding proteins that competitively bind to cytokines involved in inflammation including: tumor necrosis factor alpha (TNF-α), granulocyte macrophage colony stimulating factor (GM-CSF), interleuki
Human antigen R (HuR) and Tristetraprolin (TTP) are RNA binding proteins that competitively bind to cytokines in
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor-induced interleukin-6 expression via human antigen R.
Xu J, Su X, Shi JX, Sun H, Wu T, Shi Y. Xu J, et al. Chin Med J (Engl). 2013 Nov;126(22):4322-6. Chin Med J (Engl). 2013. PMID: 24238522
BACKGROUND: Human antigen R (HuR) is a ubiquitously expressed member of the ELAV family, and has relatively high cytoplasmic abundance in lung tissue regenerating after injury. ...CONCLUSIONS: MK2 regulates the TNF-induced expression of IL-6
BACKGROUND: Human antigen R (HuR) is a ubiquitously expressed member of the ELAV family, and has relatively high …
Pro-inflammatory cytokines reduce human TAFI expression via tristetraprolin-mediated mRNA destabilisation and decreased binding of HuR.
Komnenov D, Scipione CA, Bazzi ZA, Garabon JJ, Koschinsky ML, Boffa MB. Komnenov D, et al. Thromb Haemost. 2015 Aug;114(2):337-49. doi: 10.1160/TH14-08-0653. Epub 2015 Jun 11. Thromb Haemost. 2015. PMID: 26062599
Treatment of human HepG2 cells with pro-inflammatory cytokines TNFα, IL-6 in combination with IL-1β, or with bacterial lipopolysaccharide (LPS) decreased TAFI protein levels by approximately two-fold over 24 to 48 hours of treatment. ...We found that p …
Treatment of human HepG2 cells with pro-inflammatory cytokines TNFα, IL-6 in combination with IL-1β, or with bac …
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