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WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1.
Chen Y, Peng C, Chen J, Chen D, Yang B, He B, Hu W, Zhang Y, Liu H, Dai L, Xie H, Zhou L, Wu J, Zheng S. Chen Y, et al. Mol Cancer. 2019 Aug 22;18(1):127. doi: 10.1186/s12943-019-1053-8. Mol Cancer. 2019. PMID: 31438961 Free PMC article.
The m6A modification regulated by WTAP led to post-transcriptional suppression of ETS1, with the implication of Hu-Antigen R (HuR) as an RNA stabilizer. ...WTAP-guided m6A modification contributes to the progression of HCC via the HuR-ETS1-p21/p27
The m6A modification regulated by WTAP led to post-transcriptional suppression of ETS1, with the implication of Hu-Antigen R ( …
HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells.
Muralidharan R, Mehta M, Ahmed R, Roy S, Xu L, Aubé J, Chen A, Zhao YD, Herman T, Ramesh R, Munshi A. Muralidharan R, et al. Sci Rep. 2017 Aug 30;7(1):9694. doi: 10.1038/s41598-017-07787-4. Sci Rep. 2017. PMID: 28855578 Free PMC article.
Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer correlates with aggressive disease, drug resistance, and poor prognosis. ...CMLD-2 decreased HuR mRNA and the mRNAs of HuR-regulated proteins (Bcl2 and
Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer correlates with aggressive d
PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells.
Mukherjee J, Ohba S, See WL, Phillips JJ, Molinaro AM, Pieper RO. Mukherjee J, et al. Int J Cancer. 2016 Jul 1;139(1):99-111. doi: 10.1002/ijc.30041. Epub 2016 Mar 2. Int J Cancer. 2016. PMID: 26874904 Free PMC article.
We here describe a novel mechanism by which PKM2 interacts in the nucleus with the RNA binding protein HuR to regulate HuR sub-cellular localization, p27 levels, cell cycle progression and glioma cell growth. ...These effects could be reversed by shRNA target …
We here describe a novel mechanism by which PKM2 interacts in the nucleus with the RNA binding protein HuR to regulate HuR sub …
Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27(Kip1) levels and poor prognosis.
Kim C, Jeong DE, Heo S, Ji E, Rho JG, Jung M, Ahn S, Kim YJ, Kim YS, Nam SW, Kulkarni RN, Lee KB, Lee EK, Kim W. Kim C, et al. J Pathol. 2018 Oct;246(2):231-243. doi: 10.1002/path.5135. Epub 2018 Aug 28. J Pathol. 2018. PMID: 30014466 Free PMC article.
HuD expression was frequently lost in many human pancreatic NETs, and these pancreatic NETs showed aggressive clinicopathological phenotypes with low p27 levels, increased tumor size, higher World Health Organization grade and pT stage of the tumor, and the presence …
HuD expression was frequently lost in many human pancreatic NETs, and these pancreatic NETs showed aggressive clinicopathological phe …
HuR-targeted nanotherapy in combination with AMD3100 suppresses CXCR4 expression, cell growth, migration and invasion in lung cancer.
Muralidharan R, Panneerselvam J, Chen A, Zhao YD, Munshi A, Ramesh R. Muralidharan R, et al. Cancer Gene Ther. 2015 Dec;22(12):581-90. doi: 10.1038/cgt.2015.55. Epub 2015 Oct 23. Cancer Gene Ther. 2015. PMID: 26494555 Free PMC article.
We treated human H1299 lung cancer cells with HuR-specific siRNA contained in a folate-targeted lipid nanoparticle (HuR-FNP) plus AMD3100, and compared this with AMD3100 alone, HuR-FNP alone and no treatment. ...P27 protein expression increased …
We treated human H1299 lung cancer cells with HuR-specific siRNA contained in a folate-targeted lipid nanoparticle (HuR
CircBACH1 (hsa_circ_0061395) promotes hepatocellular carcinoma growth by regulating p27 repression via HuR.
Liu B, Yang G, Wang X, Liu J, Lu Z, Wang Q, Xu B, Liu Z, Li J. Liu B, et al. J Cell Physiol. 2020 Oct;235(10):6929-6941. doi: 10.1002/jcp.29589. Epub 2020 Jan 31. J Cell Physiol. 2020. PMID: 32003018
Finally, silencing HuR abrogated circBACH1's inhibition of p27 translation and abolished the circBACH1-induced effect on HCC proliferation. In sum, circBACH1 plays a significant role as an oncogene through the circBACH1/HuR/p27 axis in HCC development. …
Finally, silencing HuR abrogated circBACH1's inhibition of p27 translation and abolished the circBACH1-induced effect on HCC p …
The Expression of CUGBP1 After Spinal Cord Injury in Rats.
Yang L, Zhang J, Chen J, Jin H, Liu J, Huang S, Cui Z. Yang L, et al. Neurochem Res. 2015 Sep;40(9):1966-75. doi: 10.1007/s11064-015-1692-0. Epub 2015 Aug 18. Neurochem Res. 2015. PMID: 26283512
CUG-binding protein 1, a member of the CELF (CUGBP and embryonic lethal abnormal vision-like factor) family of RNA-binding proteins, is shown to be multifunctional, regulating many posttranscriptional processes including alternative splicing, de …
CUG-binding protein 1, a member of the CELF (CUGBP and embryonic lethal abnormal vision-like factor) fami …
Embryonic lethal abnormal vision-like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin-dependent kinase inhibitor p27Kip1.
Ziegeler G, Ming J, Koseki JC, Sevinc S, Chen T, Ergun S, Qin X, Aktas BH. Ziegeler G, et al. J Biol Chem. 2010 May 14;285(20):15408-19. doi: 10.1074/jbc.M110.113365. Epub 2010 Mar 23. J Biol Chem. 2010. PMID: 20332085 Free PMC article.
Post-transcriptional regulation of p27(Kip1) expression is of significant interest. The embryonic lethal abnormal vision (ELAV)-like RNA-binding protein HuR is thought be important for the translation of p27(Kip1), however, …
Post-transcriptional regulation of p27(Kip1) expression is of significant interest. The embryonic lethal abnormal
Structure and activity of the internal ribosome entry site within the human p27 Kip1 5'-untranslated region.
Coleman J, Miskimins WK. Coleman J, et al. RNA Biol. 2009 Jan-Mar;6(1):84-9. doi: 10.4161/rna.6.1.7572. Epub 2009 Jan 5. RNA Biol. 2009. PMID: 19106631 Free PMC article.
This is significant because HuR has previously been shown to inhibit p27(Kip1) IRES activity and cause downregulation of endogenous p27(Kip1) protein levels. Thus HuR may inhibit IRES activity by blocking the ribosome entry site....
This is significant because HuR has previously been shown to inhibit p27(Kip1) IRES activity and cause downregulation of endog …
Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration.
Muralidharan R, Babu A, Amreddy N, Basalingappa K, Mehta M, Chen A, Zhao YD, Kompella UB, Munshi A, Ramesh R. Muralidharan R, et al. J Nanobiotechnology. 2016 Jun 21;14(1):47. doi: 10.1186/s12951-016-0201-1. J Nanobiotechnology. 2016. PMID: 27328938 Free PMC article.
BACKGROUND: Human antigen R (HuR) is an RNA binding protein that is overexpressed in many human cancers, including lung cancer, and has been shown to regulate the expression of several oncoproteins. ...Further, reduced expression of HuR-r …
BACKGROUND: Human antigen R (HuR) is an RNA binding protein that is overexpressed in many human cancers, …
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