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Page 1
Human antigen R as a therapeutic target in pathological cardiac hypertrophy.
Green LC, Anthony SR, Slone S, Lanzillotta L, Nieman ML, Wu X, Robbins N, Jones SM, Roy S, Owens AP 3rd, Aube J, Xu L, Lorenz JN, Blaxall BC, Rubinstein J, Benoit JB, Tranter M. Green LC, et al. JCI Insight. 2019 Feb 21;4(4):e121541. doi: 10.1172/jci.insight.121541. eCollection 2019 Feb 21. JCI Insight. 2019. PMID: 30668549 Free PMC article.
We show that activation of the RNA binding protein human antigen R (HuR) is increased in the failing human heart. To determine the functional role of HuR in pathological cardiac hypertrophy, we created an inducible cardiomyocyte-specific …
We show that activation of the RNA binding protein human antigen R (HuR) is increased in the failing human
LncRNA-Safe contributes to cardiac fibrosis through Safe-Sfrp2-HuR complex in mouse myocardial infarction.
Hao K, Lei W, Wu H, Wu J, Yang Z, Yan S, Lu XA, Li J, Xia X, Han X, Deng W, Zhong G, Zhao ZA, Hu S. Hao K, et al. Theranostics. 2019 Sep 25;9(24):7282-7297. doi: 10.7150/thno.33920. eCollection 2019. Theranostics. 2019. PMID: 31695768 Free PMC article.
Among them, a lncRNA (AK137033) we named Safe was enriched in the nuclei of fibroblasts, and elevated in both myocardial infarction and TGF-β-induced cardiac fibrosis. ...RNA electrophoretic mobility shift assay and RNA immunoprecipitation assay indicated that RNA binding …
Among them, a lncRNA (AK137033) we named Safe was enriched in the nuclei of fibroblasts, and elevated in both myocardial infarction and T
Progress on the relationship between miR-125 family and tumorigenesis.
Yin H, Sun Y, Wang X, Park J, Zhang Y, Li M, Yin J, Liu Q, Wei M. Yin H, et al. Exp Cell Res. 2015 Dec 10;339(2):252-60. doi: 10.1016/j.yexcr.2015.09.015. Epub 2015 Sep 25. Exp Cell Res. 2015. PMID: 26407906 Review.
The downstream targets of miRNA-125 include transcription factors like STAT3, cytokines like IL-6 and TGF-β, tumor suppressing protein p53, pro-apoptotic protein Bak1 and RNA binding protein HuR et al. ...
The downstream targets of miRNA-125 include transcription factors like STAT3, cytokines like IL-6 and TGF-β, tumor supp …
Transcriptomic studies provide insights into the tumor suppressive role of miR-146a-5p in non-small cell lung cancer (NSCLC) cells.
Iacona JR, Monteleone NJ, Lemenze AD, Cornett AL, Lutz CS. Iacona JR, et al. RNA Biol. 2019 Dec;16(12):1721-1732. doi: 10.1080/15476286.2019.1657351. Epub 2019 Aug 23. RNA Biol. 2019. PMID: 31425002 Free PMC article.
Our transcriptomic data revealed that miR-146a-5p exerts its tumor suppressive function beyond previously reported targeting of EGFR and NF-κB signaling. miR-146a-5p mimic transfection downregulated arachidonic acid metabolism genes, the RNA-binding protein HuR, and many …
Our transcriptomic data revealed that miR-146a-5p exerts its tumor suppressive function beyond previously reported targeting of EGFR and NF- …
RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells.
Pan H, Strickland A, Madhu V, Johnson ZI, Chand SN, Brody JR, Fertala A, Zheng Z, Shapiro IM, Risbud MV. Pan H, et al. Matrix Biol. 2019 Apr;77:23-40. doi: 10.1016/j.matbio.2018.08.003. Epub 2018 Aug 7. Matrix Biol. 2019. PMID: 30092282 Free PMC article.
RNA-Sequencing data revealed that important extracellular matrix-related genes including several collagens, MMPs, aggrecan, Tgf-β3 and Sdc4 were regulated by HuR. ...In addition, messenger ribonucleoprotein immunoprecipitation demonstrated HuR binding to T
RNA-Sequencing data revealed that important extracellular matrix-related genes including several collagens, MMPs, aggrecan, Tgf-β3 an …
[Human antigen R regulates TGF-β(1) expression in airway smooth muscle cells under the stimulation of platelet-derived growth factor].
Wang N, Yan D, Gu XM, Liu Y, Jiang SJ. Wang N, et al. Zhonghua Yi Xue Za Zhi. 2016 Oct 18;96(38):3078-3082. doi: 10.3760/cma.j.issn.0376-2491.2016.38.009. Zhonghua Yi Xue Za Zhi. 2016. PMID: 27784449 Chinese.
Objective: To study the role of human antigen R (HuR) regulated transforming growth factor β(1) (TGF-β(1)) expression in airway smooth muscle cells under the stimulation of platelet-derived growth factor (PDGF). ...Conclusions: PDGF can elevate …
Objective: To study the role of human antigen R (HuR) regulated transforming growth factor β(1) (TGF-β(1) …
Human antigen R contributes to hepatic stellate cell activation and liver fibrosis.
Woodhoo A, Iruarrizaga-Lejarreta M, Beraza N, García-Rodríguez JL, Embade N, Fernández-Ramos D, Martínez-López N, Gutiérrez-De Juan V, Arteta B, Caballeria J, Lu SC, Mato JM, Varela-Rey M, Martínez-Chantar ML. Woodhoo A, et al. Hepatology. 2012 Nov;56(5):1870-82. doi: 10.1002/hep.25828. Epub 2012 Oct 9. Hepatology. 2012. PMID: 22576182 Free PMC article.
We examined the role of the RBP, human antigen R (HuR), during cholestatic liver injury and hepatic stellate cell (HSC) activation. ...HuR also controlled transforming growth factor beta (TGF-β)-induced profibrogenic actions by regulating …
We examined the role of the RBP, human antigen R (HuR), during cholestatic liver injury and hepatic stellate cel …
Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma.
Tsai IT, Kuo CC, Liou JP, Chang JY. Tsai IT, et al. J Biomed Sci. 2018 Mar 28;25(1):28. doi: 10.1186/s12929-018-0432-6. J Biomed Sci. 2018. PMID: 29592811 Free PMC article.
It destabilizes hypoxia-inducible factor (HIF)-1α mRNA by blocking the function of human antigen R. Thus, we proposed that MPT0B098 modulates hypoxia-induced EMT. ...MPT0B098 significantly inhibited transforming growth factor(TGF)-β-induced phosphoryla …
It destabilizes hypoxia-inducible factor (HIF)-1α mRNA by blocking the function of human antigen R. Thus, we proposed t …
A HuR/TGF-β1 feedback circuit regulates airway remodeling in airway smooth muscle cells.
Wang N, Yan D, Liu Y, Liu Y, Gu X, Sun J, Long F, Jiang S. Wang N, et al. Respir Res. 2016 Sep 22;17(1):117. doi: 10.1186/s12931-016-0437-1. Respir Res. 2016. PMID: 27658983 Free PMC article.
Human antigen R (HuR), the member of the Hu RNA-binding protein family, can bind to a subset of short-lived mRNAs in their 3' untranslated regions (UTR). ...METHODS: Cultured human ASM cells were stimulated by PDGF for 0, 6, 12 and 24 h. Western
Human antigen R (HuR), the member of the Hu RNA-binding protein family, can bind to a subset of short-lived mRNA
Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells.
Liu ZM, Tseng JT, Hong DY, Huang HS. Liu ZM, et al. Biochem J. 2011 Sep 1;438(2):349-58. doi: 10.1042/BJ20101653. Biochem J. 2011. PMID: 21649584
Using a biotin-labelled RNA probe pull-down assay and in vivo RNA immunoprecipitation analysis, we identified that HuR (human antigen R) bound to the TGIF mRNA 3'-UTR (3'-untranslated region) and prevented it from degradation. ATO treatment increased t …
Using a biotin-labelled RNA probe pull-down assay and in vivo RNA immunoprecipitation analysis, we identified that HuR (human
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