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RNA-Binding Proteins in the Control of LPS-Induced Macrophage Response.
Ostareck DH, Ostareck-Lederer A. Ostareck DH, et al. Front Genet. 2019 Feb 4;10:31. doi: 10.3389/fgene.2019.00031. eCollection 2019. Front Genet. 2019. PMID: 30778370 Free PMC article. Review.
Innate immune response is triggered by pathogen components, like lipopolysaccharides (LPS) of gram-negative bacteria. LPS initiates Toll-like receptor 4 (TLR4) signaling, which involves mitogen activated protein kinases (MAPK) and nuclear factor kappa B (NFκB …
Innate immune response is triggered by pathogen components, like lipopolysaccharides (LPS) of gram-negative bacteria. LPS initiates T …
Regulation of the ARE-binding proteins, TTP (tristetraprolin) and HuR (human antigen R), in inflammatory response in astrocytes.
Astakhova AA, Chistyakov DV, Sergeeva MG, Reiser G. Astakhova AA, et al. Neurochem Int. 2018 Sep;118:82-90. doi: 10.1016/j.neuint.2018.04.014. Epub 2018 Apr 24. Neurochem Int. 2018. PMID: 29702146
Two widely recognized proteins in this machinery are HuR (human antigen R) - a protein that stabilizes ARE-containing mRNA and TTP (tristetraprolin) - a protein that shortens half-lives of ARE-containing mRNA. ...Therefore we evaluated the existence of …
Two widely recognized proteins in this machinery are HuR (human antigen R) - a protein that stabilizes ARE-conta …
Ginkgo biloba extract inhibits endotoxin-induced human aortic smooth muscle cell proliferation via suppression of toll-like receptor 4 expression and NADPH oxidase activation.
Lin FY, Chen YH, Chen YL, Wu TC, Li CY, Chen JW, Lin SJ. Lin FY, et al. J Agric Food Chem. 2007 Mar 7;55(5):1977-84. doi: 10.1021/jf062945r. Epub 2007 Feb 1. J Agric Food Chem. 2007. PMID: 17266329
Toll-like receptor 4 (TLR4) initiates the inflammatory response in blood vessels in reaction to immune stimuli such as lipopolysaccharide (LPS) produced by gram-negative bacteria. ...The effects of G. biloba extract on LPS-induced proliferation and TLR4 expre …
Toll-like receptor 4 (TLR4) initiates the inflammatory response in blood vessels in reaction to immune stimuli such as lipopol …
Reduction of TLR4 mRNA stability and protein expressions through inhibiting cytoplasmic translocation of HuR transcription factor by E₂ and/or ERα in LPS-treated H9c2 cardiomyoblast cells.
Fan MJ, Huang-Liu R, Shen CY, Ju DT, Lin YM, Pai P, Huang PY, Ho TJ, Tsai FJ, Tsai CH, Huang CY. Fan MJ, et al. Chin J Physiol. 2014 Feb 28;57(1):8-18. doi: 10.4077/CJP.2014.BAC197. Chin J Physiol. 2014. PMID: 24621334
Toll-like receptor 4 (TLR4) mRNAs often contain AU-rich elements (AREs) in their 3'-untranslated regions (3'UTR) which have a high affinity for RNA-binding proteins. It is not known whether E₂ and ERα affect TLR4 mRNA stability and TLR4 protein express …
Toll-like receptor 4 (TLR4) mRNAs often contain AU-rich elements (AREs) in their 3'-untranslated regions (3'UTR) which have a …
The role of human antigen R, an RNA-binding protein, in mediating the stabilization of toll-like receptor 4 mRNA induced by endotoxin: a novel mechanism involved in vascular inflammation.
Lin FY, Chen YH, Lin YW, Tsai JS, Chen JW, Wang HJ, Chen YL, Li CY, Lin SJ. Lin FY, et al. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2622-9. doi: 10.1161/01.ATV.0000246779.78003.cf. Epub 2006 Sep 21. Arterioscler Thromb Vasc Biol. 2006. PMID: 16990552
OBJECTIVE: Lipopolysaccharide (LPS) interacts with toll-like receptor 4 (TLR4) and induces proliferation of vascular smooth muscle cells (VSMCs) which plays a causal role in atherogenesis. ...It is not know whether the RNA-binding protein, human antigen
OBJECTIVE: Lipopolysaccharide (LPS) interacts with toll-like receptor 4 (TLR4) and induces proliferation of vascular smooth mu …
Eotaxin-2 increased toll-like receptor 4 expression in endothelial cells in vitro and exacerbates high-cholesterol diet-induced atherogenesis in vivo.
Tsai CS, Huang CY, Chen CH, Lin YW, Shih CM, Tsao NW, Chiang KH, Lee CY, Jeng H, Lin FY. Tsai CS, et al. Am J Transl Res. 2016 Dec 15;8(12):5338-5353. eCollection 2016. Am J Transl Res. 2016. PMID: 28078007 Free PMC article.
Toll-like receptor 4 (TLR4) plays a major role mediating vascular inflammation, which is related to atherogenesis. In the results, we demonstrated that eotaxin-2 potentially impairs the tube formation capacity of human coronary artery endothelial cells (HCAEC …
Toll-like receptor 4 (TLR4) plays a major role mediating vascular inflammation, which is related to atherogenesis. In the resu …
The GroEL protein of Porphyromonas gingivalis regulates atherogenic phenomena in endothelial cells mediated by upregulating toll-like receptor 4 expression.
Huang CY, Shih CM, Tsao NW, Lin YW, Shih CC, Chiang KH, Shyue SK, Chang YJ, Hsieh CK, Lin FY. Huang CY, et al. Am J Transl Res. 2016 Feb 15;8(2):384-404. eCollection 2016. Am J Transl Res. 2016. PMID: 27158334 Free PMC article.
Here, we constructed recombinant GroEL from P. gingivalis to investigate its effects in human coronary artery endothelial cells (HCAECs) in vitro and on aortas of high-cholesterol (HC)-fed B57BL/6 and B57BL/6-Tlr4(lps-del) mice in vivo. ...Furthermore, GroEL interac …
Here, we constructed recombinant GroEL from P. gingivalis to investigate its effects in human coronary artery endothelial cells (HCAE …
Interleukin-1/toll-like receptor-induced nuclear factor kappa B signaling participates in intima hyperplasia after carotid artery balloon injury in goto-kakizaki rats: a potential target therapy pathway.
Zhang X, Wang Y, Hu W, Li D, Zhou Z, Pan D, Wu W, Xu T. Zhang X, et al. PLoS One. 2014 Aug 1;9(8):e103794. doi: 10.1371/journal.pone.0103794. eCollection 2014. PLoS One. 2014. PMID: 25083789 Free PMC article.
Interleukin-1/Toll-like receptor (IL-1/TLR) signaling is involved in innate and adaptive immune responses, but whether and how the IL-1/TLR-induced nuclear factor kappa B (NFκB) pathway plays key roles in intimal formation is unclear. ...TLR4, IL-1 receptor associat …
Interleukin-1/Toll-like receptor (IL-1/TLR) signaling is involved in innate and adaptive immune responses, but whether and how the IL …
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