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Apigenin Inhibits UVB-Induced Skin Carcinogenesis: The Role of Thrombospondin-1 as an Anti-Inflammatory Factor.
Mirzoeva S, Tong X, Bridgeman BB, Plebanek MP, Volpert OV. Mirzoeva S, et al. Neoplasia. 2018 Sep;20(9):930-942. doi: 10.1016/j.neo.2018.07.005. Epub 2018 Aug 15. Neoplasia. 2018. PMID: 30118999 Free PMC article.
We have previously demonstrated that apigenin promotes the expression of antiangiogenic protein thrombospondin-1 (TSP1) via a mechanism driven by mRNA-binding protein HuR. ...Apigenin significantly inhibited UVB-induced carcinogenesis in the wild-type (WT) animals b …
We have previously demonstrated that apigenin promotes the expression of antiangiogenic protein thrombospondin-1 (TSP1) via a mechani …
Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1.
Tong X, Mirzoeva S, Veliceasa D, Bridgeman BB, Fitchev P, Cornwell ML, Crawford SE, Pelling JC, Volpert OV. Tong X, et al. Oncotarget. 2014 Nov 30;5(22):11413-27. doi: 10.18632/oncotarget.2551. Oncotarget. 2014. PMID: 25526033 Free PMC article.
Knockdown studies implicated the RNA-binding protein HuR, which controls mRNA stability and translation. Apigenin increased HuR cytoplasmic localization and physical association with TSP1 mRNA causing de novo TSP1 synthesis. HuR cytoplasmic loca …
Knockdown studies implicated the RNA-binding protein HuR, which controls mRNA stability and translation. Apigenin increased HuR
Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis.
Gubin MM, Calaluce R, Davis JW, Magee JD, Strouse CS, Shaw DP, Ma L, Brown A, Hoffman T, Rold TL, Atasoy U. Gubin MM, et al. Cell Cycle. 2010 Aug 15;9(16):3337-46. doi: 10.4161/cc.9.16.12711. Epub 2010 Aug 17. Cell Cycle. 2010. PMID: 20724828 Free PMC article.
HuR controls the expression of multiple genes involved in angiogenesis including VEGFα, HIF1α and thrombospondin 1 (TSP1). We investigated the role of HuR in estrogen receptor negative (ER(-)) breast cancer. ...The putative mechanism seems to be an anti-angio
HuR controls the expression of multiple genes involved in angiogenesis including VEGFα, HIF1α and thrombospondin 1 (TSP1). We
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.
Mazan-Mamczarz K, Hagner PR, Corl S, Srikantan S, Wood WH, Becker KG, Gorospe M, Keene JD, Levenson AS, Gartenhaus RB. Mazan-Mamczarz K, et al. Oncogene. 2008 Oct 16;27(47):6151-63. doi: 10.1038/onc.2008.215. Epub 2008 Jul 21. Oncogene. 2008. PMID: 18641687 Free PMC article.
Increases in the tumor microvascular density are accompanied by a strong reduction in the levels of the angiogenesis inhibitor thrombospondin-1 (TSP1), but the mechanisms underlying this process are unknown. We show that TSP1 expression is controlled, at least in pa …
Increases in the tumor microvascular density are accompanied by a strong reduction in the levels of the angiogenesis inhibitor thrombospondi …
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