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145 results
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WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1.
Chen Y, Peng C, Chen J, Chen D, Yang B, He B, Hu W, Zhang Y, Liu H, Dai L, Xie H, Zhou L, Wu J, Zheng S. Chen Y, et al. Mol Cancer. 2019 Aug 22;18(1):127. doi: 10.1186/s12943-019-1053-8. Mol Cancer. 2019. PMID: 31438961 Free PMC article.
METHODS: We determined the expression of WTAP and its correlation with clinicopathological features using tissue microarrays and the Cancer Genome Atlas (TCGA) dataset. ...The m6A modification regulated by WTAP led to post-transcriptional suppression of ETS1, with the impl …
METHODS: We determined the expression of WTAP and its correlation with clinicopathological features using tissue microarrays and the …
METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer.
Yue B, Song C, Yang L, Cui R, Cheng X, Zhang Z, Zhao G. Yue B, et al. Mol Cancer. 2019 Oct 13;18(1):142. doi: 10.1186/s12943-019-1065-4. Mol Cancer. 2019. PMID: 31607270 Free PMC article.
METHODS: qRT-PCR and immunohistochemistry were used to evaluate the expression of methyltransferase-like 3 (METTL3) in gastric cancer (GC). ...The m6A modification of ZMYM1 mRNA by METTL3 enhanced its stability relying on the "reader" protein HuR (also known as E
METHODS: qRT-PCR and immunohistochemistry were used to evaluate the expression of methyltransferase-like 3 (METTL3) in gastric cancer …
5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs.
Chen X, Li A, Sun BF, Yang Y, Han YN, Yuan X, Chen RX, Wei WS, Liu Y, Gao CC, Chen YS, Zhang M, Ma XD, Liu ZW, Luo JH, Lyu C, Wang HL, Ma J, Zhao YL, Zhou FJ, Huang Y, Xie D, Yang YG. Chen X, et al. Nat Cell Biol. 2019 Aug;21(8):978-990. doi: 10.1038/s41556-019-0361-y. Epub 2019 Jul 29. Nat Cell Biol. 2019. PMID: 31358969
Here, we provide the single-nucleotide resolution landscape of messenger RNA m(5)C modifications in human urothelial carcinoma of the bladder (UCB). ...YBX1 maintains the stability of its target mRNA by recruiting ELAVL1. Moreover, NSUN2 and YBX1 are demonstrated to …
Here, we provide the single-nucleotide resolution landscape of messenger RNA m(5)C modifications in human urothelial carcinoma of the …
Abemaciclib Is Effective Against Pancreatic Cancer Cells and Synergizes with HuR and YAP1 Inhibition.
Dhir T, Schultz CW, Jain A, Brown SZ, Haber A, Goetz A, Xi C, Su GH, Xu L, Posey J 3rd, Jiang W, Yeo CJ, Golan T, Pishvaian MJ, Brody JR. Dhir T, et al. Mol Cancer Res. 2019 Oct;17(10):2029-2041. doi: 10.1158/1541-7786.MCR-19-0589. Epub 2019 Aug 5. Mol Cancer Res. 2019. PMID: 31383722 Free PMC article.
We determined that inhibitors of HuR (ELAVL1), a prosurvival mRNA stability factor that regulates cyclin D1, and an inhibitor of Yes-Associated Protein 1 (YAP1), a pro-oncogenic, transcriptional coactivator important for CDK6 and cyclin D1, were both synergistic wit …
We determined that inhibitors of HuR (ELAVL1), a prosurvival mRNA stability factor that regulates cyclin D1, and an inhibitor …
Multiple functions of HuR in urinary tumors.
Zhang F, Cai Z, Lv H, Li W, Liang M, Wei X, Zhou F. Zhang F, et al. J Cancer Res Clin Oncol. 2019 Jan;145(1):11-18. doi: 10.1007/s00432-018-2778-2. Epub 2018 Oct 28. J Cancer Res Clin Oncol. 2019. PMID: 30370480 Review.
PURPOSE: Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. ...What's more, more preclinical and clinical trials of thi …
PURPOSE: Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu f …
LncRNA-HGBC stabilized by HuR promotes gallbladder cancer progression by regulating miR-502-3p/SET/AKT axis.
Hu YP, Jin YP, Wu XS, Yang Y, Li YS, Li HF, Xiang SS, Song XL, Jiang L, Zhang YJ, Huang W, Chen SL, Liu FT, Chen C, Zhu Q, Chen HZ, Shao R, Liu YB. Hu YP, et al. Mol Cancer. 2019 Nov 21;18(1):167. doi: 10.1186/s12943-019-1097-9. Mol Cancer. 2019. PMID: 31752906 Free PMC article.
LncRNA-HGBC specifically bound to RNA binding protein Hu Antigen R (HuR) that in turn stabilized lncRNA-HGBC. LncRNA-HGBC functioned as a competitive endogenous RNA to bind to miR-502-3p that inhibits target gene SET. ...Clinically, lncRNA-HGBC express …
LncRNA-HGBC specifically bound to RNA binding protein Hu Antigen R (HuR) that in turn stabilized lncRNA-HGBC. LncRNA-HG …
Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes.
Chen Y, Yang F, Fang E, Xiao W, Mei H, Li H, Li D, Song H, Wang J, Hong M, Wang X, Huang K, Zheng L, Tong Q. Chen Y, et al. Cell Death Differ. 2019 Jul;26(7):1346-1364. doi: 10.1038/s41418-018-0220-6. Epub 2018 Oct 19. Cell Death Differ. 2019. PMID: 30341421 Free PMC article.
Mechanistic studies reveal that circAGO2 physically interacts with human antigen R (HuR) protein to facilitate its activation and enrichment on the 3'-untranslated region of target genes, resulting in reduction of AGO2 binding and repression of AGO2/mi …
Mechanistic studies reveal that circAGO2 physically interacts with human antigen R (HuR) protein to facilitate i …
Human antigen R as a therapeutic target in pathological cardiac hypertrophy.
Green LC, Anthony SR, Slone S, Lanzillotta L, Nieman ML, Wu X, Robbins N, Jones SM, Roy S, Owens AP 3rd, Aube J, Xu L, Lorenz JN, Blaxall BC, Rubinstein J, Benoit JB, Tranter M. Green LC, et al. JCI Insight. 2019 Feb 21;4(4):e121541. doi: 10.1172/jci.insight.121541. eCollection 2019 Feb 21. JCI Insight. 2019. PMID: 30668549 Free PMC article.
We show that activation of the RNA binding protein human antigen R (HuR) is increased in the failing human heart. To determine the functional role of HuR in pathological cardiac hypertrophy, we created an inducible cardiomyocyte-specific …
We show that activation of the RNA binding protein human antigen R (HuR) is increased in the failing human
Identification and Functional Characterization of Long Non-coding RNA MIR22HG as a Tumor Suppressor for Hepatocellular Carcinoma.
Zhang DY, Zou XJ, Cao CH, Zhang T, Lei L, Qi XL, Liu L, Wu DH. Zhang DY, et al. Theranostics. 2018 Jun 13;8(14):3751-3765. doi: 10.7150/thno.22493. eCollection 2018. Theranostics. 2018. PMID: 30083257 Free PMC article.
However, the function of lncRNAs in human hepatocellular carcinoma (HCC) remains largely unknown. Our study was designed to explore the biological function and clinical implication of lncRNA MIR22HG in HCC. ...Additionally, MIR22HG directly interacted with HuR
However, the function of lncRNAs in human hepatocellular carcinoma (HCC) remains largely unknown. Our study was designed to explore t …
Human Antigen R (HuR): A Regulator of Heme Oxygenase-1 Cytoprotection in Mouse and Human Liver Transplant Injury.
Dery KJ, Nakamura K, Kadono K, Hirao H, Kageyama S, Ito T, Kojima H, Kaldas FM, Busuttil RW, Kupiec-Weglinski JW. Dery KJ, et al. Hepatology. 2019 Dec 27. doi: 10.1002/hep.31093. Online ahead of print. Hepatology. 2019. PMID: 31879990
Here, we hypothesized that human antigen R (HuR), the stabilizer of adenylate-uridylate (AU)-rich mRNAs, is required for hepatoprotection in LT. ...Using the HuR-inhibitor, we showed that HuR likely regulates HO-1 through its 3' untransla …
Here, we hypothesized that human antigen R (HuR), the stabilizer of adenylate-uridylate (AU)-rich mRNAs, is requ …
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