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2001 1
2003 1
2004 1
2005 2
2006 2
2007 2
2008 2
2009 3
2010 1
2011 2
2012 6
2013 2
2014 4
2015 2
2016 2
2017 5
2018 6
2019 3
2020 3
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47 results
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MiR-155-5p controls colon cancer cell migration via post-transcriptional regulation of Human Antigen R (HuR).
Al-Haidari A, Algaber A, Madhi R, Syk I, Thorlacius H. Al-Haidari A, et al. Cancer Lett. 2018 May 1;421:145-151. doi: 10.1016/j.canlet.2018.02.026. Epub 2018 Feb 20. Cancer Lett. 2018. PMID: 29471005
HuR (ELAVL1) is overexpressed in CRC and has been reported to promote colon cancer growth by targeting RNA in the cell cytoplasm. Herein, the role of miR-155-5p in regulating HuR expression and cell migration was examined in colon cancer cells.
HuR (ELAVL1) is overexpressed in CRC and has been reported to promote colon cancer growth by targeting RNA in the cell
Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes.
Chen Y, Yang F, Fang E, Xiao W, Mei H, Li H, Li D, Song H, Wang J, Hong M, Wang X, Huang K, Zheng L, Tong Q. Chen Y, et al. Cell Death Differ. 2019 Jul;26(7):1346-1364. doi: 10.1038/s41418-018-0220-6. Epub 2018 Oct 19. Cell Death Differ. 2019. PMID: 30341421 Free PMC article.
CircAGO2 is up-regulated in gastric cancer, colon cancer, prostate cancer, and neuroblastoma, and is associated with poor prognosis of patients. ...Mechanistic studies reveal that circAGO2 physically interacts with human antigen R (HuR) protein …
CircAGO2 is up-regulated in gastric cancer, colon cancer, prostate cancer, and neuroblastoma, and is associated with poor prognosis o …
HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis.
Lang M, Berry D, Passecker K, Mesteri I, Bhuju S, Ebner F, Sedlyarov V, Evstatiev R, Dammann K, Loy A, Kuzyk O, Kovarik P, Khare V, Beibel M, Roma G, Meisner-Kober N, Gasche C. Lang M, et al. Cancer Res. 2017 May 1;77(9):2424-2438. doi: 10.1158/0008-5472.CAN-15-1726. Epub 2017 Feb 20. Cancer Res. 2017. PMID: 28428272 Free PMC article.
In human specimens, levels of cytoplasmic HuR were increased in colonic epithelial cells from patients with IBD, IBD-cancer, FAP-adenoma, and colorectal cancer, but not in patients with IBD-dysplasia. ...In contrast, HuR inhibition in APC(Min) mice, a model o …
In human specimens, levels of cytoplasmic HuR were increased in colonic epithelial cells from patients with IBD, IBD-cancer, F …
Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.
Lan Y, Xiao X, He Z, Luo Y, Wu C, Li L, Song X. Lan Y, et al. Nucleic Acids Res. 2018 Jun 20;46(11):5809-5821. doi: 10.1093/nar/gky214. Nucleic Acids Res. 2018. PMID: 29931370 Free PMC article.
Overexpressed in colon carcinoma-1 (OCC-1) is one of the earliest annotated long noncoding RNAs (lncRNAs) in colorectal cancer (CRC); however, its function remains largely unknown. ...OCC-1 exerts its function by binding to and destabilizing HuR (ELAVL1), a c …
Overexpressed in colon carcinoma-1 (OCC-1) is one of the earliest annotated long noncoding RNAs (lncRNAs) in colorectal cancer (CRC); …
Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells.
Bowler E, Porazinski S, Uzor S, Thibault P, Durand M, Lapointe E, Rouschop KMA, Hancock J, Wilson I, Ladomery M. Bowler E, et al. BMC Cancer. 2018 Apr 2;18(1):355. doi: 10.1186/s12885-018-4227-7. BMC Cancer. 2018. PMID: 29606096 Free PMC article.
The expression of the splice factors SRSF1, SRSF2, SRSF3, SAM68, HuR, hnRNPA1, and of the splice factor kinases SRPK1 and CLK1 increased significantly in hypoxia. ...The expression of several splice factors and splice factor kinases increases during hypoxia, in particular …
The expression of the splice factors SRSF1, SRSF2, SRSF3, SAM68, HuR, hnRNPA1, and of the splice factor kinases SRPK1 and CLK1 increa …
Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?
Eberhardt W, Nasrullah U, Haeussler K. Eberhardt W, et al. Cells. 2019 Jul 30;8(8):797. doi: 10.3390/cells8080797. Cells. 2019. PMID: 31366165 Free PMC article. Review.
An increased expression and cytoplasmic abundance of the ubiquitous RNA binding protein human antigen R (HuR) is critically implicated in the dysregulated control of post- transcriptional gene expression during colorectal cancer development and is freq …
An increased expression and cytoplasmic abundance of the ubiquitous RNA binding protein human antigen R (HuR) is …
CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype.
Lal S, Cheung EC, Zarei M, Preet R, Chand SN, Mambelli-Lisboa NC, Romeo C, Stout MC, Londin E, Goetz A, Lowder CY, Nevler A, Yeo CJ, Campbell PM, Winter JM, Dixon DA, Brody JR. Lal S, et al. Mol Cancer Res. 2017 Jun;15(6):696-707. doi: 10.1158/1541-7786.MCR-16-0361. Epub 2017 Feb 27. Mol Cancer Res. 2017. PMID: 28242812 Free PMC article.
The RNA-binding protein HuR (ELAVL1) supports a pro-oncogenic network in gastrointestinal (GI) cancer cells through enhanced HuR expression. ...Importantly, HuR-deficient MIA PaCa-2 and Hs 766T cells were unable to engraft tumors in vivo compared with …
The RNA-binding protein HuR (ELAVL1) supports a pro-oncogenic network in gastrointestinal (GI) cancer cells through enhanced …
Butyrate mediated regulation of RNA binding proteins in the post-transcriptional regulation of inflammatory gene expression.
Torun A, Enayat S, Sheraj I, Tunçer S, Ülgen DH, Banerjee S. Torun A, et al. Cell Signal. 2019 Dec;64:109410. doi: 10.1016/j.cellsig.2019.109410. Epub 2019 Sep 2. Cell Signal. 2019. PMID: 31487531
Using bioinformatics analyses of publicly available microarray data as well as colon cancer cell lines treated with sodium butyrate, we have observed that butyrate treatment led to a general reduction in expression of several (but not all) RBPs and inhibition in the cytoso …
Using bioinformatics analyses of publicly available microarray data as well as colon cancer cell lines treated with sodium butyrate, …
Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L.
Winkler C, Doller A, Imre G, Badawi A, Schmid T, Schulz S, Steinmeyer N, Pfeilschifter J, Rajalingam K, Eberhardt W. Winkler C, et al. Cell Death Dis. 2014 Jul 10;5(7):e1321. doi: 10.1038/cddis.2014.279. Cell Death Dis. 2014. PMID: 25010987 Free PMC article.
Using ribonucleoprotein (RNP)-immunoprecipitation assay, we identified the proapoptotic caspase-2L encoding mRNA as a novel target of the ubiquitous RNA-binding protein HuR in DLD-1 colon carcinoma cells. ...Collectively, our findings support the hypothesis that …
Using ribonucleoprotein (RNP)-immunoprecipitation assay, we identified the proapoptotic caspase-2L encoding mRNA as a novel target of the ub …
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation.
Embade N, Fernández-Ramos D, Varela-Rey M, Beraza N, Sini M, Gutiérrez de Juan V, Woodhoo A, Martínez-López N, Rodríguez-Iruretagoyena B, Bustamante FJ, de la Hoz AB, Carracedo A, Xirodimas DP, Rodríguez MS, Lu SC, Mato JM, Martínez-Chantar ML. Embade N, et al. Hepatology. 2012 Apr;55(4):1237-48. doi: 10.1002/hep.24795. Epub 2012 Mar 1. Hepatology. 2012. PMID: 22095636 Free PMC article.
Hu antigen R (HuR) is a central RNA-binding protein regulating cell dedifferentiation, proliferation, and survival, which are well-established hallmarks of cancer. ...Here, we unraveled a novel mean of regulation of HuR expression in hepatocellular car …
Hu antigen R (HuR) is a central RNA-binding protein regulating cell dedifferentiation, proliferation, and survival, whi …
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