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2000 1
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2019 1
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HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation.
Wang W, Caldwell MC, Lin S, Furneaux H, Gorospe M. Wang W, et al. EMBO J. 2000 May 15;19(10):2340-50. doi: 10.1093/emboj/19.10.2340. EMBO J. 2000. PMID: 10811625 Free PMC article.
In gel-shift assays using radiolabeled cyclin RNA transcripts and RKO protein extracts, only those transcripts corresponding to the 3'-untranslated regions of cyclins A and B1 formed RNA-protein complexes in a cell cycle-dependent fashion. HuR directly bound mRNAs e …
In gel-shift assays using radiolabeled cyclin RNA transcripts and RKO protein extracts, only those transcripts corresponding to the 3 …
Interaction between C2ORF68 and HuR in human colorectal cancer.
Lv Z, He K, Shi L, Shi K, Jiang T, Chen Y. Lv Z, et al. Oncol Rep. 2019 Mar;41(3):1918-1928. doi: 10.3892/or.2019.6973. Epub 2019 Jan 21. Oncol Rep. 2019. PMID: 30664176
The mRNA and protein expression levels of C2orf68, HuR, Bcl‑2, c‑Myc, cyclin D and cyclin A were upregulated, while the expression of Bax was downregulated in LoVo+c2orf68 and LoVo+c20rf68,‑HuR cells. Expression levels of C2orf68, HuR, Bcl‑2, c‑Myc, …
The mRNA and protein expression levels of C2orf68, HuR, Bcl‑2, c‑Myc, cyclin D and cyclin A were upregulated, while the …
HuR cytoplasmic expression is associated with increased cyclin A expression and poor outcome with upper urinary tract urothelial carcinoma.
Liang PI, Li WM, Wang YH, Wu TF, Wu WR, Liao AC, Shen KH, Wei YC, Hsing CH, Shiue YL, Huang HY, Hsu HP, Chen LT, Lin CY, Tai C, Lin CM, Li CF. Liang PI, et al. BMC Cancer. 2012 Dec 21;12:611. doi: 10.1186/1471-2407-12-611. BMC Cancer. 2012. PMID: 23259573 Free PMC article.
BACKGROUND: HuR is an RNA-binding protein that post-transcriptionally modulates the expressions of various target genes implicated in carcinogenesis, such as CCNA2 encoding cyclin A. ...Immunostaining for HuR and cyclin A was performed and evaluated by …
BACKGROUND: HuR is an RNA-binding protein that post-transcriptionally modulates the expressions of various target genes implicated in …
HuR cytoplasmic expression is associated with increased cyclin A expression and inferior disease-free survival in patients with gastrointestinal stromal tumours (GISTs).
Wei YC, Chou FF, Li CF, Li WM, Chen YY, Lan J, Li SH, Fang FM, Hu TH, Yu SC, Eng HL, Uen YH, Tian YF, Wang JC, Huang HY. Wei YC, et al. Histopathology. 2013 Oct;63(4):445-54. doi: 10.1111/his.12148. Epub 2013 Jul 26. Histopathology. 2013. PMID: 23889148

AIMS: HuR is an RNA-binding protein that post-transcriptionally modulates the expression of various target genes involved in carcinogenesis, such as CCNA2, which encodes cyclin A. ...Importantly, HuR cytoplasmic expression (P < 0.001) and cyclin A o

AIMS: HuR is an RNA-binding protein that post-transcriptionally modulates the expression of various target genes involved in carcinog …
The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking.
Doller A, Badawi A, Schmid T, Brauss T, Pleli T, zu Heringdorf DM, Piiper A, Pfeilschifter J, Eberhardt W. Doller A, et al. Exp Cell Res. 2015 Jan 1;330(1):66-80. doi: 10.1016/j.yexcr.2014.09.010. Epub 2014 Sep 21. Exp Cell Res. 2015. PMID: 25240929
Despite of elevations in HuR expression levels, an increase in cytoplasmic HuR abundance in many cases correlates with a high grade of malignancy. ...Concomitant with changes in intracellular HuR localization, both cytoskeletal inhibitors markedly decreased t …
Despite of elevations in HuR expression levels, an increase in cytoplasmic HuR abundance in many cases correlates with a high …
Impaired liver regeneration in mice lacking glycine N-methyltransferase.
Varela-Rey M, Fernández-Ramos D, Martínez-López N, Embade N, Gómez-Santos L, Beraza N, Vázquez-Chantada M, Rodríguez J, Luka Z, Wagner C, Lu SC, Martínez-Chantar ML, Mato JM. Varela-Rey M, et al. Hepatology. 2009 Aug;50(2):443-52. doi: 10.1002/hep.23033. Hepatology. 2009. PMID: 19582817 Free PMC article.
In GNMT-KO mice, nuclear factor kappaB (NFkappaB), signal transducer and activator of transcription-3 (STAT3), inducible nitric oxide synthase (iNOS), cyclin D1, cyclin A, and poly (ADP-ribose) polymerase were activated at baseline. ...NFkappaB, cyclin D1 and …
In GNMT-KO mice, nuclear factor kappaB (NFkappaB), signal transducer and activator of transcription-3 (STAT3), inducible nitric oxide syntha …
Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR.
Doller A, Schlepckow K, Schwalbe H, Pfeilschifter J, Eberhardt W. Doller A, et al. Mol Cell Biol. 2010 Mar;30(6):1397-410. doi: 10.1128/MCB.01373-09. Epub 2010 Jan 19. Mol Cell Biol. 2010. PMID: 20086103 Free PMC article.
Stabilization of mRNA by the ubiquitous RNA binding protein human antigen R (HuR), a member of the embryonic lethal abnormal vision (ELAV) protein family, requires canonical binding to AU-rich element (ARE)-bearing target mR …
Stabilization of mRNA by the ubiquitous RNA binding protein human antigen R (HuR), a member of the embryonic
HuR knockdown changes the oncogenic potential of oral cancer cells.
Kakuguchi W, Kitamura T, Kuroshima T, Ishikawa M, Kitagawa Y, Totsuka Y, Shindoh M, Higashino F. Kakuguchi W, et al. Mol Cancer Res. 2010 Apr;8(4):520-8. doi: 10.1158/1541-7786.MCR-09-0367. Epub 2010 Mar 23. Mol Cancer Res. 2010. PMID: 20332213 Free article.
HuR binds to AU-rich element-containing mRNA to protect them from rapid degradation. Here, we show that knockdown of HuR changes the oncogenic properties of oral cancer cells. ...Additionally, the motile and invasive activities of the cells decreased remarkably by
HuR binds to AU-rich element-containing mRNA to protect them from rapid degradation. Here, we show that knockdown of HuR chang
Prognostic significance of cyclin A in gastric cancer.
Mrena J, Wiksten JP, Kokkola A, Nordling S, Haglund C, Ristimäki A. Mrena J, et al. Int J Cancer. 2006 Oct 15;119(8):1897-901. doi: 10.1002/ijc.21944. Int J Cancer. 2006. PMID: 16708383 Free article.
Specimens were stained by cyclin A and HuR specific monoclonal antibodies. Nuclear immunostaining detected in > or =5% of the tumor cells was considered the cut-off for cyclin A positivity. ...Furthermore, cyclin A expression was associated with cyt …
Specimens were stained by cyclin A and HuR specific monoclonal antibodies. Nuclear immunostaining detected in > or =5% of t …
COX-2 is associated with proliferation and apoptosis markers and serves as an independent prognostic factor in gastric cancer.
Mrena J, Wiksten JP, Kokkola A, Nordling S, Ristimäki A, Haglund C. Mrena J, et al. Tumour Biol. 2010 Jan;31(1):1-7. doi: 10.1007/s13277-009-0001-4. Epub 2009 Dec 18. Tumour Biol. 2010. PMID: 20237896
From 342 consecutive patients, 337 archival tissue specimens were available for immunohistochemistry of COX-2, HuR, cyclin A, MMP-2, p53, p21, and Ki-67 and 313 for analysis of DNA index and S-phase fraction by flow cytometry. ...
From 342 consecutive patients, 337 archival tissue specimens were available for immunohistochemistry of COX-2, HuR, cyclin A, …
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