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2003 1
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2018 1
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Abemaciclib Is Effective Against Pancreatic Cancer Cells and Synergizes with HuR and YAP1 Inhibition.
Dhir T, Schultz CW, Jain A, Brown SZ, Haber A, Goetz A, Xi C, Su GH, Xu L, Posey J 3rd, Jiang W, Yeo CJ, Golan T, Pishvaian MJ, Brody JR. Dhir T, et al. Mol Cancer Res. 2019 Oct;17(10):2029-2041. doi: 10.1158/1541-7786.MCR-19-0589. Epub 2019 Aug 5. Mol Cancer Res. 2019. PMID: 31383722 Free PMC article.
We determined that inhibitors of HuR (ELAVL1), a prosurvival mRNA stability factor that regulates cyclin D1, and an inhibitor of Yes-Associated Protein 1 (YAP1), a pro-oncogenic, transcriptional coactivator important for CDK6 and cyclin D1
We determined that inhibitors of HuR (ELAVL1), a prosurvival mRNA stability factor that regulates cyclin D1, and …
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs.
Lal A, Mazan-Mamczarz K, Kawai T, Yang X, Martindale JL, Gorospe M. Lal A, et al. EMBO J. 2004 Aug 4;23(15):3092-102. doi: 10.1038/sj.emboj.7600305. Epub 2004 Jul 15. EMBO J. 2004. PMID: 15257295 Free PMC article.
RNA-binding proteins HuR and AUF1 bind to many common AU-rich target mRNAs and exert opposing influence on target mRNA stability, but the functional interactions between HuR and AUF1 have not been systematically studied. Here, using common target RNAs encoding p21 a …
RNA-binding proteins HuR and AUF1 bind to many common AU-rich target mRNAs and exert opposing influence on target mRNA stability, but …
Posttranscriptional regulation of cyclin D1 by ARE-binding proteins AUF1 and HuR in cycling myoblasts.
Ghosh U, Adhya S. Ghosh U, et al. J Biosci. 2018 Sep;43(4):685-691. J Biosci. 2018. PMID: 30207314 Free article.
In this report we examine the roles of two RBPs that bind to AU-rich elements (ARE) - AUF1 and HuR - in the stability and translation of cyclin D1 (Ccnd1) mRNA in rat myoblasts transiting the G phase of the cell cycle, and their interactions with miRNAs. ...I …
In this report we examine the roles of two RBPs that bind to AU-rich elements (ARE) - AUF1 and HuR - in the stability and translation …
Regulation of cyclin D1 by arsenic and microRNA inhibits adipogenesis.
Beezhold K, Klei LR, Barchowsky A. Beezhold K, et al. Toxicol Lett. 2017 Jan 4;265:147-155. doi: 10.1016/j.toxlet.2016.12.002. Epub 2016 Dec 5. Toxicol Lett. 2017. PMID: 27932253 Free PMC article.
Arsenic increased the expression of miR-29b in white adipose tissue, as well as human mesenchymal stem cells (hMSCs) isolated from adipose tissue. ...This paradox was attributed to a requirement for miR-29 in regulating cyclin D1 expression as stable inhibiti …
Arsenic increased the expression of miR-29b in white adipose tissue, as well as human mesenchymal stem cells (hMSCs) isolated from ad …
Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9.
Yuan Z, Sanders AJ, Ye L, Wang Y, Jiang WG. Yuan Z, et al. Oncol Rep. 2011 Jul;26(1):237-45. doi: 10.3892/or.2011.1271. Epub 2011 Apr 18. Oncol Rep. 2011. PMID: 21503589
Furthermore, we report that the decreased cell growth rate in MCF7 cells is seen together with a reduction in cyclin D1 transcript and protein levels and that the change in invasiveness in MDA-MB-231 cells seems to be linked with decreased MMP-9 levels. ...These cha …
Furthermore, we report that the decreased cell growth rate in MCF7 cells is seen together with a reduction in cyclin D1 transc …
The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking.
Doller A, Badawi A, Schmid T, Brauss T, Pleli T, zu Heringdorf DM, Piiper A, Pfeilschifter J, Eberhardt W. Doller A, et al. Exp Cell Res. 2015 Jan 1;330(1):66-80. doi: 10.1016/j.yexcr.2014.09.010. Epub 2014 Sep 21. Exp Cell Res. 2015. PMID: 25240929
Despite of elevations in HuR expression levels, an increase in cytoplasmic HuR abundance in many cases correlates with a high grade of malignancy. ...Concomitant with changes in intracellular HuR localization, both cytoskeletal inhibitors markedly decreased t …
Despite of elevations in HuR expression levels, an increase in cytoplasmic HuR abundance in many cases correlates with a high …
Human antigen R contributes to hepatic stellate cell activation and liver fibrosis.
Woodhoo A, Iruarrizaga-Lejarreta M, Beraza N, García-Rodríguez JL, Embade N, Fernández-Ramos D, Martínez-López N, Gutiérrez-De Juan V, Arteta B, Caballeria J, Lu SC, Mato JM, Varela-Rey M, Martínez-Chantar ML. Woodhoo A, et al. Hepatology. 2012 Nov;56(5):1870-82. doi: 10.1002/hep.25828. Epub 2012 Oct 9. Hepatology. 2012. PMID: 22576182 Free PMC article.
We examined the role of the RBP, human antigen R (HuR), during cholestatic liver injury and hepatic stellate cell (HSC) activation. ...HuR regulated platelet-derived growth factor (PDGF)-induced proliferation and migration and controlled the exp …
We examined the role of the RBP, human antigen R (HuR), during cholestatic liver injury and hepatic stellate cel …
Il-19 reduces VSMC activation by regulation of mRNA regulatory factor HuR and reduction of mRNA stability.
Cuneo AA, Herrick D, Autieri MV. Cuneo AA, et al. J Mol Cell Cardiol. 2010 Oct;49(4):647-54. doi: 10.1016/j.yjmcc.2010.04.016. Epub 2010 May 6. J Mol Cell Cardiol. 2010. PMID: 20451530 Free PMC article.
In cultured, primary human VSMC, IL-19 reduces abundance of proliferative and inflammatory gene proteins and mRNA, including Cyclin D1, IL-1beta, IL-8, and COX2. IL-19 does not inhibit NF-kappaB, but does transiently reduce cytoplasmic abundance of the mRNA s …
In cultured, primary human VSMC, IL-19 reduces abundance of proliferative and inflammatory gene proteins and mRNA, including Cycli
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase.
Martínez-Chantar ML, Vázquez-Chantada M, Garnacho M, Latasa MU, Varela-Rey M, Dotor J, Santamaria M, Martínez-Cruz LA, Parada LA, Lu SC, Mato JM. Martínez-Chantar ML, et al. Gastroenterology. 2006 Jul;131(1):223-32. doi: 10.1053/j.gastro.2006.04.019. Gastroenterology. 2006. PMID: 16831604
How SAM regulates hepatocyte growth is unclear, but because SAM blocks hepatocyte growth factor (HGF)-induced cyclin D1 expression and DNA synthesis without affecting HGF-induced extracellular signal-regulated kinase phosphorylation, the mitogen-activated protein ki …
How SAM regulates hepatocyte growth is unclear, but because SAM blocks hepatocyte growth factor (HGF)-induced cyclin D1 expres …
Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer.
Topisirovic I, Siddiqui N, Orolicki S, Skrabanek LA, Tremblay M, Hoang T, Borden KL. Topisirovic I, et al. Mol Cell Biol. 2009 Mar;29(5):1152-62. doi: 10.1128/MCB.01532-08. Epub 2008 Dec 29. Mol Cell Biol. 2009. PMID: 19114552 Free PMC article.
Eukaryotic translation initiation factor 4E (eIF4E) is encoded by a potent oncogene which is highly elevated in many human cancers. ...Further, HuR and eIF4E regulate a common set of transcripts involved in cellular proliferation (cyclin D1 and c-myc) …
Eukaryotic translation initiation factor 4E (eIF4E) is encoded by a potent oncogene which is highly elevated in many human cancers. . …
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