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HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells.
Muralidharan R, Mehta M, Ahmed R, Roy S, Xu L, Aubé J, Chen A, Zhao YD, Herman T, Ramesh R, Munshi A. Muralidharan R, et al. Sci Rep. 2017 Aug 30;7(1):9694. doi: 10.1038/s41598-017-07787-4. Sci Rep. 2017. PMID: 28855578 Free PMC article.
Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer correlates with aggressive disease, drug resistance, and poor prognosis. ...CMLD-2 decreased HuR mRNA and the mRNAs of HuR-regulated proteins (Bcl2 and p2
Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer correlates with aggressive d
Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration.
Muralidharan R, Babu A, Amreddy N, Basalingappa K, Mehta M, Chen A, Zhao YD, Kompella UB, Munshi A, Ramesh R. Muralidharan R, et al. J Nanobiotechnology. 2016 Jun 21;14(1):47. doi: 10.1186/s12951-016-0201-1. J Nanobiotechnology. 2016. PMID: 27328938 Free PMC article.
BACKGROUND: Human antigen R (HuR) is an RNA binding protein that is overexpressed in many human cancers, including lung cancer, and has been shown to regulate the expression of several oncoproteins. ...Further, reduced expression of HuR-r …
BACKGROUND: Human antigen R (HuR) is an RNA binding protein that is overexpressed in many human cancers, …
The prolyl isomerase pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteins.
Krishnan N, Titus MA, Thapar R. Krishnan N, et al. PLoS One. 2014 Jan 9;9(1):e85427. doi: 10.1371/journal.pone.0085427. eCollection 2014. PLoS One. 2014. PMID: 24416409 Free PMC article.
Several targets of Pin1 such as c-Myc, the Androgen Receptor, Estrogen Receptor-alpha, Cyclin D1, Cyclin E, p53, RAF kinase and NCOA3 are deregulated in cancer. ...We identified HuR and AUF1 as Pin1 interacting ARE-binding proteins in vivo. Pin1 was al …
Several targets of Pin1 such as c-Myc, the Androgen Receptor, Estrogen Receptor-alpha, Cyclin D1, Cyclin E, p53, RAF ki …
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