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The long non-coding RNA H19 suppresses carcinogenesis and chemoresistance in hepatocellular carcinoma.
Schultheiss CS, Laggai S, Czepukojc B, Hussein UK, List M, Barghash A, Tierling S, Hosseini K, Golob-Schwarzl N, Pokorny J, Hachenthal N, Schulz M, Helms V, Walter J, Zimmer V, Lammert F, Bohle RM, Dandolo L, Haybaeck J, Kiemer AK, Kessler SM. Schultheiss CS, et al. Cell Stress. 2017 Aug 25;1(1):37-54. doi: 10.15698/cst2017.10.105. Cell Stress. 2017. PMID: 31225433 Free PMC article.
We therefore determined the action of H19 in three different human hepatoma cell lines (HepG2, Plc/Prf5, and Huh7). Clonogenicity and proliferation assays showed that H19 overexpression could suppress tumor cell survival and proliferation after treatment with either sorafe …
We therefore determined the action of H19 in three different human hepatoma cell lines (HepG2, Plc/Prf5, and Huh7). Clonogenicity and …
Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells.
Latorre E, Tebaldi T, Viero G, Spartà AM, Quattrone A, Provenzani A. Latorre E, et al. Mol Cancer. 2012 Mar 21;11:13. doi: 10.1186/1476-4598-11-13. Mol Cancer. 2012. PMID: 22436134 Free PMC article.
In this study, we investigated the role of HuR in the apoptosis and in the chemoresistance induced by the widely used anticancer drug doxorubicin in human breast cancer cells (MCF-7). ...Reducing HuR levels diminished the apoptotic response to doxor …
In this study, we investigated the role of HuR in the apoptosis and in the chemoresistance induced by the widely used anticancer drug …
Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells.
Badawi A, Biyanee A, Nasrullah U, Winslow S, Schmid T, Pfeilschifter J, Eberhardt W. Badawi A, et al. Oncotarget. 2018 Apr 6;9(26):18367-18385. doi: 10.18632/oncotarget.24840. eCollection 2018 Apr 6. Oncotarget. 2018. PMID: 29719611 Free PMC article.
In accordance with the significant drug-induced increase in cytoplasmic HuR abundance, doxorubicin and paclitaxel increased the interaction of cytoplasmic HuR with the 5'untranslated region (5'UTR) of caspase-2 as shown by RNA pull down assay. ...Luciferase a …
In accordance with the significant drug-induced increase in cytoplasmic HuR abundance, doxorubicin and paclitaxel increased th …
Loss of protein kinase Cdelta/HuR interaction is necessary to doxorubicin resistance in breast cancer cell lines.
Latorre E, Castiglioni I, Gatto P, Carelli S, Quattrone A, Provenzani A. Latorre E, et al. J Pharmacol Exp Ther. 2014 Apr;349(1):99-106. doi: 10.1124/jpet.113.211839. Epub 2014 Feb 3. J Pharmacol Exp Ther. 2014. PMID: 24492650
In in vitro select doxorubicin-resistant human breast cancer cell lines upregulating the multidrug resistance marker ABCG2, PKCdelta, and HuR proteins were coordinately downregulated together with the doxorubicin target TOP2A protein whose mRNA was …
In in vitro select doxorubicin-resistant human breast cancer cell lines upregulating the multidrug resistance marker ABCG2, PK …
HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity.
Ale-Agha N, Galban S, Sobieroy C, Abdelmohsen K, Gorospe M, Sies H, Klotz LO. Ale-Agha N, et al. Hepatology. 2009 Nov;50(5):1567-76. doi: 10.1002/hep.23146. Hepatology. 2009. PMID: 19676129 Free PMC article.
Second, HuR silencing reduced both half-life and the levels of beta-catenin mRNA, also a target of HuR; accordingly, HuR silencing lowered the levels of whole-cell and membrane-associated beta-catenin. ...Finally, HuR was demonstrated to support GJIC a …
Second, HuR silencing reduced both half-life and the levels of beta-catenin mRNA, also a target of HuR; accordingly, HuR …
Translational control of TOP2A influences doxorubicin efficacy.
Srikantan S, Abdelmohsen K, Lee EK, Tominaga K, Subaran SS, Kuwano Y, Kulshrestha R, Panchakshari R, Kim HH, Yang X, Martindale JL, Marasa BS, Kim MM, Wersto RP, Indig FE, Chowdhury D, Gorospe M. Srikantan S, et al. Mol Cell Biol. 2011 Sep;31(18):3790-801. doi: 10.1128/MCB.05639-11. Epub 2011 Jul 18. Mol Cell Biol. 2011. PMID: 21768308 Free PMC article.
Using a novel MS2-tagged RNA precipitation method, we identified microRNA miR-548c-3p as a mediator of these effects and further uncovered that the interaction of miR-548c-3p with the TOP2A 3'UTR repressed TOP2A translation by antagonizing the action of HuR. Lowering TOP2A …
Using a novel MS2-tagged RNA precipitation method, we identified microRNA miR-548c-3p as a mediator of these effects and further uncovered t …
Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder.
Guo J, Lv J, Chang S, Chen Z, Lu W, Xu C, Liu M, Pang X. Guo J, et al. Oncotarget. 2016 Jul 19;7(29):45249-45262. doi: 10.18632/oncotarget.9932. Oncotarget. 2016. PMID: 27303922 Free PMC article.
Here we show that HuR is required for the efficacy of chemotherapies in urothelial carcinoma of the bladder. We identify pyrvinium pamoate, an FDA-approved anthelminthic drug, as a novel HuR inhibitor that dose-dependently inhibited cytoplasmic accumulation of Hu …
Here we show that HuR is required for the efficacy of chemotherapies in urothelial carcinoma of the bladder. We identify pyrvinium pa …
Ribonuclease activity of p53 in cytoplasm in response to various stress signals.
Derech-Haim S, Teiblum G, Kadosh R, Rahav G, Bonda E, Sredni B, Bakhanashvili M. Derech-Haim S, et al. Cell Cycle. 2012 Apr 1;11(7):1400-13. doi: 10.4161/cc.19812. Epub 2012 Apr 1. Cell Cycle. 2012. PMID: 22421154
Ribonuclease activity is enhanced in cytoplasmic extracts of HCT116 (p53+/+) cells exposed to gamma-irradiation or treated by the non-genotoxic drug AS101 but decreased following treatment by genotoxic (e.g., doxorubicin) or non-genotoxic (e.g., DFMO) agents, thus indicati …
Ribonuclease activity is enhanced in cytoplasmic extracts of HCT116 (p53+/+) cells exposed to gamma-irradiation or treated by the non-genoto …
A recently evolved class of alternative 3'-terminal exons involved in cell cycle regulation by topoisomerase inhibitors.
Dutertre M, Chakrama FZ, Combe E, Desmet FO, Mortada H, Polay Espinoza M, Gratadou L, Auboeuf D. Dutertre M, et al. Nat Commun. 2014 Feb 28;5:3395. doi: 10.1038/ncomms4395. Nat Commun. 2014. PMID: 24577238 Free article.
The RNA-binding protein HuR/ELAVL1 is a major regulator of this specific set of alternative 3'-terminal exons. HuR binding to the alternative 3'-terminal exon in the pre-messenger RNA promotes its splicing, and is reduced by topoisomerase inhibitors. ...
The RNA-binding protein HuR/ELAVL1 is a major regulator of this specific set of alternative 3'-terminal exons. HuR bind …
Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development.
Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S, Davidson NO. Giammanco A, et al. Cancer Res. 2014 Sep 15;74(18):5322-35. doi: 10.1158/0008-5472.CAN-14-0726. Epub 2014 Aug 1. Cancer Res. 2014. PMID: 25085247 Free PMC article.
In this study, we explored the impact of conditional, tissue-specific genetic deletion of HuR on intestinal growth and tumorigenesis in mice. Mice lacking intestinal expression of HuR (Hur (IKO) mice) displayed reduced levels of cell proliferation in the smal …
In this study, we explored the impact of conditional, tissue-specific genetic deletion of HuR on intestinal growth and tumorigenesis …