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The neural ELAVL protein HuB enhances endogenous proto-oncogene activation.
Hatanaka T, Higashino F, Tei K, Yasuda M. Hatanaka T, et al. Biochem Biophys Res Commun. 2019 Sep 17;517(2):330-337. doi: 10.1016/j.bbrc.2019.07.089. Epub 2019 Jul 26. Biochem Biophys Res Commun. 2019. PMID: 31358321
The cytoplasmic distribution of the HuR/ELAVL1 (embryonic lethal abnormal vision 1) protein is recognized as an important prognostic factor of malignant tumors. ...Finally, co-transfection of HuB with the E1 region of type 5 human
The cytoplasmic distribution of the HuR/ELAVL1 (embryonic lethal abnormal vision 1) protein is rec …
An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation.
Degese MS, Tanos T, Naipauer J, Gingerich T, Chiappe D, Echeverria P, LaMarre J, Gutkind JS, Coso OA. Degese MS, et al. Biochem J. 2015 Apr 1;467(1):77-90. doi: 10.1042/BJ20141100. Biochem J. 2015. PMID: 25588078
Several AU-rich binding proteins (AUBPs), including HuR (Hu-antigen R, Elav-like protein 1, ELAVL1) and KSRP (far upstream element-binding protein 2, KHSRP) bind to a fos AU-rich element (ARE) present in the 3'-UTR (untranslated region) o …
Several AU-rich binding proteins (AUBPs), including HuR (Hu-antigen R, Elav-like protein 1, ELAVL1) and K …
Impairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome patients.
Feng X, Shikama Y, Shichishima T, Noji H, Ikeda K, Ogawa K, Kimura H, Takeishi Y, Kimura J. Feng X, et al. PLoS One. 2013 Apr 12;8(4):e61107. doi: 10.1371/journal.pone.0061107. Print 2013. PLoS One. 2013. PMID: 23593403 Free PMC article.
Emetine increased both transcription and mRNA stability of FOS. p38 MAPK inhibition abolished the emetine-induced increase of FOS transcription but did not affect FOS mRNA stabilization. The binding of an AU-rich element (ARE)-binding protein HuR to …
Emetine increased both transcription and mRNA stability of FOS. p38 MAPK inhibition abolished the emetine-induced increase of FOS
ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation.
Atasoy U, Watson J, Patel D, Keene JD. Atasoy U, et al. J Cell Sci. 1998 Nov;111 ( Pt 21):3145-56. J Cell Sci. 1998. PMID: 9763509 Free article.
ELAV proteins are implicated in regulating the stability and translation of cytokine and growth regulatory mRNAs such as GM-CSF, IL-2, c-myc, c-fos and GLUT1 by binding to their AU-rich 3'UTRs. ...Therefore, much like the primarily cytoplasmic HuB, HuA becomes tempo …
ELAV proteins are implicated in regulating the stability and translation of cytokine and growth regulatory mRNAs such as GM-CSF, IL-2, c-myc …
Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein.
Ma WJ, Cheng S, Campbell C, Wright A, Furneaux H. Ma WJ, et al. J Biol Chem. 1996 Apr 5;271(14):8144-51. doi: 10.1074/jbc.271.14.8144. J Biol Chem. 1996. PMID: 8626503 Free article.
We have identified and cloned a fourth member of this family (HuR) that is expressed in a wide variety of cell types. The purified recombinant protein binds avidly to the AU-rich element in c-fos and interleukin-3 mRNAs. In the case of the c-fos AU-rich eleme …
We have identified and cloned a fourth member of this family (HuR) that is expressed in a wide variety of cell types. The purified re …
Loss of CARM1 is linked to reduced HuR function in replicative senescence.
Pang L, Tian H, Chang N, Yi J, Xue L, Jiang B, Gorospe M, Zhang X, Wang W. Pang L, et al. BMC Mol Biol. 2013 Jul 9;14:15. doi: 10.1186/1471-2199-14-15. BMC Mol Biol. 2013. PMID: 23837869 Free PMC article.
In senescent human diploid fibroblasts (HDFs), reduced CARM1 was accompanied by reduced HuR methylation. In addition, knockdown of CARM1 or mutation of the major methylation site of HuR in HDF markedly impaired the ability of HuR to regulate the expres …
In senescent human diploid fibroblasts (HDFs), reduced CARM1 was accompanied by reduced HuR methylation. In addition, knockdow …
HuR knockdown changes the oncogenic potential of oral cancer cells.
Kakuguchi W, Kitamura T, Kuroshima T, Ishikawa M, Kitagawa Y, Totsuka Y, Shindoh M, Higashino F. Kakuguchi W, et al. Mol Cancer Res. 2010 Apr;8(4):520-8. doi: 10.1158/1541-7786.MCR-09-0367. Epub 2010 Mar 23. Mol Cancer Res. 2010. PMID: 20332213 Free article.
HuR binds to AU-rich element-containing mRNA to protect them from rapid degradation. Here, we show that knockdown of HuR changes the oncogenic properties of oral cancer cells. ...In the HuR-knockdown cancer cells, the cytoplasmic expression of c-fos, c
HuR binds to AU-rich element-containing mRNA to protect them from rapid degradation. Here, we show that knockdown of HuR chang
Down-regulation of soluble guanylyl cyclase expression by cyclic AMP is mediated by mRNA-stabilizing protein HuR.
Klöss S, Srivastava R, Mülsch A. Klöss S, et al. Mol Pharmacol. 2004 Jun;65(6):1440-51. doi: 10.1124/mol.65.6.1440. Mol Pharmacol. 2004. PMID: 15155837
In cultured smooth muscle cells from rat aorta, forskolin induced a rapid increase in Fos/p-Fos protein levels and activator protein 1 (AP-1) binding activity. Inhibition of this transcription factor by an AP-1 decoy prevented the forskolin-induced down-regulation o …
In cultured smooth muscle cells from rat aorta, forskolin induced a rapid increase in Fos/p-Fos protein levels and activator p …
Distinct domains of AU-rich elements exert different functions in mRNA destabilization and stabilization by p38 mitogen-activated protein kinase or HuR.
Winzen R, Gowrishankar G, Bollig F, Redich N, Resch K, Holtmann H. Winzen R, et al. Mol Cell Biol. 2004 Jun;24(11):4835-47. doi: 10.1128/MCB.24.11.4835-4847.2004. Mol Cell Biol. 2004. PMID: 15143177 Free PMC article.
Stabilization by ARE binding protein HuR requires different sequence elements. Binding but no stabilization is observed with the IL-8 ARE. Responsiveness to HuR is gained by exchanging the auxiliary domain of the IL-8 ARE with that of GM-CSF or with a domain of the …
Stabilization by ARE binding protein HuR requires different sequence elements. Binding but no stabilization is observed with the IL-8 …
[Aberrant regulation of mRNA 3' untranslated region in cancers and inflammation].
Nguyen-Chi M, Morello D. Nguyen-Chi M, et al. Med Sci (Paris). 2008 Mar;24(3):290-6. doi: 10.1051/medsci/2008243290. Med Sci (Paris). 2008. PMID: 18334178 Free article. Review. French.
Many of them encode oncogenes (for instance c-Myc and c-Fos), cell cycle regulators (cyclin D1, A1, B1), cytokines (TNFalpha, IL2) and growth factors (GM-CSF) which are overexpressed in cancer or inflammatory diseases due to increased mRNA stability and/or translation. ... …
Many of them encode oncogenes (for instance c-Myc and c-Fos), cell cycle regulators (cyclin D1, A1, B1), cytokines (TNFalpha, IL2) an …
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