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2001 1
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2011 3
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2016 3
2017 2
2018 3
2019 5
2020 1
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Essential role of METTL3-mediated m(6)A modification in glioma stem-like cells maintenance and radioresistance.
Visvanathan A, Patil V, Arora A, Hegde AS, Arivazhagan A, Santosh V, Somasundaram K. Visvanathan A, et al. Oncogene. 2018 Jan 25;37(4):522-533. doi: 10.1038/onc.2017.351. Epub 2017 Oct 9. Oncogene. 2018. PMID: 28991227
Despite advances in biology and therapeutic modalities, existence of highly tumorigenic glioma stem-like cells (GSCs) makes glioblastomas (GBMs) invincible. ...Further, we found that the recruitment of Human antigen R (HuR) to m(6)A-modif …
Despite advances in biology and therapeutic modalities, existence of highly tumorigenic glioma stem-like cells (GSCs) makes gl …
Deletion of the RNA regulator HuR in tumor-associated microglia and macrophages stimulates anti-tumor immunity and attenuates glioma growth.
Wang J, Leavenworth JW, Hjelmeland AB, Smith R, Patel N, Borg B, Si Y, King PH. Wang J, et al. Glia. 2019 Dec;67(12):2424-2439. doi: 10.1002/glia.23696. Epub 2019 Aug 10. Glia. 2019. PMID: 31400163
Analysis of tumor composition by flow cytometry showed that tumor-associated macrophages (TAMs) were decreased, more polarized toward an M1-like phenotype, and had reduced PD-L1 expression. ...In summary, HuR is a key modulator of pro-glioma responses by micr …
Analysis of tumor composition by flow cytometry showed that tumor-associated macrophages (TAMs) were decreased, more polarized toward an M1- …
Long non-coding RNA SNHG12promotes the proliferation and migration of glioma cells by binding to HuR.
Lei W, Wang ZL, Feng HJ, Lin XD, Li CZ, Fan D. Lei W, et al. Int J Oncol. 2018 Sep;53(3):1374-1384. doi: 10.3892/ijo.2018.4478. Epub 2018 Jul 11. Int J Oncol. 2018. PMID: 30015836
The association between SNHG12 and Hu antigen R (HuR) was also determined using RNA immunoprecipitation (RIP) and RNA pull-down assays. ...The silencing of SNHG12 expression by RNA interference led to a reduced viability and mobility, and in an increased apop …
The association between SNHG12 and Hu antigen R (HuR) was also determined using RNA immunoprecipitation (RIP) and RNA p …
PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells.
Mukherjee J, Ohba S, See WL, Phillips JJ, Molinaro AM, Pieper RO. Mukherjee J, et al. Int J Cancer. 2016 Jul 1;139(1):99-111. doi: 10.1002/ijc.30041. Epub 2016 Mar 2. Int J Cancer. 2016. PMID: 26874904 Free PMC article.
We here describe a novel mechanism by which PKM2 interacts in the nucleus with the RNA binding protein HuR to regulate HuR sub-cellular localization, p27 levels, cell cycle progression and glioma cell growth. ...These results define a novel mechanism by which …
We here describe a novel mechanism by which PKM2 interacts in the nucleus with the RNA binding protein HuR to regulate HuR sub …
Hu antigen R (HuR) multimerization contributes to glioma disease progression.
Filippova N, Yang X, Ananthan S, Sorochinsky A, Hackney JR, Gentry Z, Bae S, King P, Nabors LB. Filippova N, et al. J Biol Chem. 2017 Oct 13;292(41):16999-17010. doi: 10.1074/jbc.M117.797878. Epub 2017 Aug 8. J Biol Chem. 2017. PMID: 28790173 Free PMC article.
Previous reports overwhelmingly support the role of the RNA-binding protein Hu antigen R (HuR) as a positive regulator of glioma disease progression. ...Here, we report HuR aggregation (multimerization) in glioma and the analysis of this …
Previous reports overwhelmingly support the role of the RNA-binding protein Hu antigen R (HuR) as a positive regulator …
LncRNA HOXB-AS1 promotes cell growth in multiple myeloma via FUT4 mRNA stability by ELAVL1.
Chen R, Zhang X, Wang C. Chen R, et al. J Cell Biochem. 2020 Oct;121(10):4043-4051. doi: 10.1002/jcb.29573. Epub 2019 Dec 30. J Cell Biochem. 2020. PMID: 31886581
LncRNA HOXB cluster antisense RNA 1 (HOXB-AS1) was once revealed to facilitate glioma progression by affecting cellular activities of glioma cells. ...In subsequence, it was observed from mechanism assays that HOXB-AS1 enhanced the interaction between ELAVL1
LncRNA HOXB cluster antisense RNA 1 (HOXB-AS1) was once revealed to facilitate glioma progression by affecting cellular activities of …
MiR-146b-5p overexpression attenuates stemness and radioresistance of glioma stem cells by targeting HuR/lincRNA-p21/β-catenin pathway.
Yang W, Yu H, Shen Y, Liu Y, Yang Z, Sun T. Yang W, et al. Oncotarget. 2016 Jul 5;7(27):41505-41526. doi: 10.18632/oncotarget.9214. Oncotarget. 2016. PMID: 27166258 Free PMC article.
Downregulation of lincRNA-p21 in GSCs was resulted from upregulation of Hu antigen R (HuR) expression caused by miR-146b-5p downregulation. ...These findings suggest that targeting the miR-146b-5p/HuR/lincRNA-p21/β-catenin signaling pathway may be valu …
Downregulation of lincRNA-p21 in GSCs was resulted from upregulation of Hu antigen R (HuR) expression caused by miR-146 …
Anti-cancer effects of the HuR inhibitor, MS-444, in malignant glioma cells.
Wang J, Hjelmeland AB, Nabors LB, King PH. Wang J, et al. Cancer Biol Ther. 2019;20(7):979-988. doi: 10.1080/15384047.2019.1591673. Epub 2019 Apr 16. Cancer Biol Ther. 2019. PMID: 30991885 Free PMC article.
These findings provide strong evidence that HuR might be a viable therapeutic target in glioblastoma. In this report, we investigated the effects of MS-444, a small molecule inhibitor of HuR, in xenograft-derived human glioblastoma cells and BTICs. ...At sub- …
These findings provide strong evidence that HuR might be a viable therapeutic target in glioblastoma. In this report, we investigated …
Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function.
Filippova N, Yang X, King P, Nabors LB. Filippova N, et al. J Biol Chem. 2012 Sep 14;287(38):32277-87. doi: 10.1074/jbc.M112.353912. Epub 2012 Jul 24. J Biol Chem. 2012. PMID: 22829587 Free PMC article.
Hu antigen R (HuR) is an mRNA-binding protein belonging to the ELAV family. It is highly expressed in cancer and involved in cell survival and proliferation. The impact of post-translational regulation of HuR and resulting cellular effects are poorly u …
Hu antigen R (HuR) is an mRNA-binding protein belonging to the ELAV family. It is highly expressed in cancer and involv …
The Diverse Roles of RNA-Binding Proteins in Glioma Development.
Velasco MX, Kosti A, Penalva LOF, Hernández G. Velasco MX, et al. Adv Exp Med Biol. 2019;1157:29-39. doi: 10.1007/978-3-030-19966-1_2. Adv Exp Med Biol. 2019. PMID: 31342436
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