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Elevated Hu-Antigen Receptor (HuR) Expression is Associated with Tumor Aggressiveness and Poor Prognosis but not with COX-2 Expression in Invasive Breast Carcinoma Patients.
Giaginis C, Sampani A, Kotta-Loizou I, Giannopoulou I, Danas E, Politi E, Tsourouflis G, Kouraklis G, Patsouris E, Keramopoulos A, Nakopoulou L, Theocharis S. Giaginis C, et al. Pathol Oncol Res. 2018 Jul;24(3):631-640. doi: 10.1007/s12253-017-0288-1. Epub 2017 Aug 14. Pathol Oncol Res. 2018. PMID: 28808873 Free article.
Hu-antigen R (HuR), a RNA-binding protein, is considered to play a crucial role in tumor development and progression by stabilizing or regulating a group of cellular mRNAs of cancer-related genes, such as cyclooxygenase-2 (COX-2). The present study aimed to e …
Hu-antigen R (HuR), a RNA-binding protein, is considered to play a crucial role in tumor development and progression by …
Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells.
Hostetter C, Licata LA, Witkiewicz A, Costantino CL, Yeo CJ, Brody JR, Keen JC. Hostetter C, et al. Cancer Biol Ther. 2008 Sep;7(9):1496-506. doi: 10.4161/cbt.7.9.6490. Epub 2008 Sep 23. Cancer Biol Ther. 2008. PMID: 18769129
While much is known about overexpression of key growth promoting receptors including EGF, erbB2/Her2 and IGF receptors and subsequent activation of MAPK signaling associated with resistance, the underlying mechanism in the development of resistance still remains unknown. . …
While much is known about overexpression of key growth promoting receptors including EGF, erbB2/Her2 and IGF receptors and subsequent …
Oncogenic p95HER2 regulates Na+-HCO3- cotransporter NBCn1 mRNA stability in breast cancer cells via 3'UTR-dependent processes.
Gorbatenko A, Olesen CW, Loebl N, Sigurdsson HH, Bianchi C, Pedraz-Cuesta E, Christiansen J, Pedersen SF. Gorbatenko A, et al. Biochem J. 2016 Nov 1;473(21):4027-4044. doi: 10.1042/BCJ20160054. Epub 2016 Sep 8. Biochem J. 2016. PMID: 27609814
We previously demonstrated that NBCn1 expression and promoter activity are strongly increased in breast cancer cells expressing a constitutively active oncogenic human epidermal growth factor receptor 2 (HER2) (p95HER2). ...The NBCn1 3'UTR interacted directly with t …
We previously demonstrated that NBCn1 expression and promoter activity are strongly increased in breast cancer cells expressing a constituti …
Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy.
Wang J, Li D, Wang B, Wu Y. Wang J, et al. Breast Cancer Res Treat. 2013 Sep;141(2):213-24. doi: 10.1007/s10549-013-2679-7. Epub 2013 Sep 14. Breast Cancer Res Treat. 2013. PMID: 24036660

Cytoplasmic HuR expression was present in 60 cases (43.2 %). The expression of cytoplasmic HuR was significantly associated with high nuclear grade (P < 0.0001) and ER (P = 0.001) and PR (P = 0.005) status. Multivariate regression analysis further revealed that h

Cytoplasmic HuR expression was present in 60 cases (43.2 %). The expression of cytoplasmic HuR was significantly associated wi …
Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer.
Zhu Z, Wang B, Bi J, Zhang C, Guo Y, Chu H, Liang X, Zhong C, Wang J. Zhu Z, et al. Tumour Biol. 2013 Aug;34(4):2299-308. doi: 10.1007/s13277-013-0774-3. Epub 2013 Apr 19. Tumour Biol. 2013. PMID: 23605320
The purpose of this study was to determine the expression of HuR and P-gp in human breast cancer tissues and analyze the relationship between HuR or P-gp expression and the clinical-pathological variables and patient outcomes. Immunohistochemistry was used to …
The purpose of this study was to determine the expression of HuR and P-gp in human breast cancer tissues and analyze the relat …
Hepatitis B virus X upregulates HuR protein level to stabilize HER2 expression in hepatocellular carcinoma cells.
Hung CM, Huang WC, Pan HL, Chien PH, Lin CW, Chen LC, Chien YF, Lin CC, Leow KH, Chen WS, Chen JY, Ho CY, Hou PS, Chen YJ. Hung CM, et al. Biomed Res Int. 2014;2014:827415. doi: 10.1155/2014/827415. Epub 2014 Feb 27. Biomed Res Int. 2014. PMID: 24719890 Free PMC article.
However, it remains unclear whether and how HBx regulates HER2 expression. In this study, our data showed that HBx expression increased HER2 protein level via enhancing its mRNA stability. The induction of RNA-binding protein HuR expression by HBx mediated th …
However, it remains unclear whether and how HBx regulates HER2 expression. In this study, our data showed that HBx expression increas …
Pharmacogenetics in pancreatic cancer. Highlights from the 45th ASCO annual meeting. Orlando, FL, USA. May 29-June 2, 2009.
Strimpakos AS, Syrigos KN, Saif MW. Strimpakos AS, et al. JOP. 2009 Jul 6;10(4):357-60. JOP. 2009. PMID: 19581734 Free article.
KRAS status, mismatch repair genes status, UGT1A1 polymorphisms), lung cancer (EGFR mutations, ERCC1 mutations), breast cancer (HER2/neu overexpression) and many others. ...Interesting abstracts and announcements from the perspective of pharmacogenomics in pancreatic cance …
KRAS status, mismatch repair genes status, UGT1A1 polymorphisms), lung cancer (EGFR mutations, ERCC1 mutations), breast cancer (HER2/ …
Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR.
Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY. Gabai VL, et al. Mol Cell Biol. 2012 Mar;32(5):929-40. doi: 10.1128/MCB.05921-11. Epub 2012 Jan 3. Mol Cell Biol. 2012. PMID: 22215620 Free PMC article.
Previously we demonstrated that the heat shock transcription factor Hsf1 is indispensable for transformation of mammary epithelial cells by the Her2 oncogene. ...Indeed, here we report that Hsf1 knockout suppressed mammary hyperplasia in Her2-expressing mice and red …
Previously we demonstrated that the heat shock transcription factor Hsf1 is indispensable for transformation of mammary epithelial cells by …
Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells.
Hsia TC, Tu CY, Chen YJ, Wei YL, Yu MC, Hsu SC, Tsai SL, Chen WS, Yeh MH, Yen CJ, Yu YL, Huang TC, Huang CY, Hung MC, Huang WC. Hsia TC, et al. Mol Pharmacol. 2013 Apr;83(4):857-69. doi: 10.1124/mol.112.082743. Epub 2013 Jan 25. Mol Pharmacol. 2013. PMID: 23355539
Lapatinib, a dual epidermal growth factor receptor (EGFR)/human epidermal growth factor receptor 2 (HER2) kinase inhibitor, showed clinical benefits in advanced HER2-positive breast cancer patients. ...Strikingly, independent of its kinase activity, the eleva …
Lapatinib, a dual epidermal growth factor receptor (EGFR)/human epidermal growth factor receptor 2 (HER2) kinase inhibitor, sh …
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