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2005 2
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2012 1
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2014 1
2016 1
2020 0
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Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR.
Linker K, Pautz A, Fechir M, Hubrich T, Greeve J, Kleinert H. Linker K, et al. Nucleic Acids Res. 2005 Aug 26;33(15):4813-27. doi: 10.1093/nar/gki797. Print 2005. Nucleic Acids Res. 2005. PMID: 16126846 Free PMC article.
In these cells, iNOS expression was increased. Mapping of the binding site revealed KSRP interacting with the most 3'-located AU-rich element (ARE) of the human iNOS mRNA. This sequence is also the target for HuR, an iNOS mRNA stabilizing protei …
In these cells, iNOS expression was increased. Mapping of the binding site revealed KSRP interacting with the most 3'-located AU-rich …
Berberine Decreased Inducible Nitric Oxide Synthase mRNA Stability through Negative Regulation of Human Antigen R in Lipopolysaccharide-Induced Macrophages.
Shin JS, Choi HE, Seo S, Choi JH, Baek NI, Lee KT. Shin JS, et al. J Pharmacol Exp Ther. 2016 Jul;358(1):3-13. doi: 10.1124/jpet.115.231043. Epub 2016 May 12. J Pharmacol Exp Ther. 2016. PMID: 27189969
Suppression of LPS-induced iNOS protein expression by berberine occurred via a human antigen R (HuR)-mediated reduction of iNOS mRNA stability. Molecular data revealed that the suppression on the LPS-induced HuR binding to iNOS
Suppression of LPS-induced iNOS protein expression by berberine occurred via a human antigen R (HuR)-medi …
microRNA and human inducible nitric oxide synthase.
Guo Z, Geller DA. Guo Z, et al. Vitam Horm. 2014;96:19-27. doi: 10.1016/B978-0-12-800254-4.00002-7. Vitam Horm. 2014. PMID: 25189382 Review.
Important posttranscriptional mechanisms also regulate human iNOS mRNA stability through RNA binding proteins HuR, TTP, KSRP, and PABP. Recently, there are several miRNAs that were validated to regulate human and rodent iNOS gene expression. Amo …
Important posttranscriptional mechanisms also regulate human iNOS mRNA stability through RNA binding proteins HuR, TTP, …
Regulation of the expression of inducible nitric oxide synthase.
Pautz A, Art J, Hahn S, Nowag S, Voss C, Kleinert H. Pautz A, et al. Nitric Oxide. 2010 Sep 15;23(2):75-93. doi: 10.1016/j.niox.2010.04.007. Epub 2010 May 8. Nitric Oxide. 2010. PMID: 20438856 Review.
However, dysfunctional induction of iNOS expression seems to be involved in the pathophysiology of several human diseases. Therefore iNOS has to be regulated very tightly. ...However, at least in the human system, also post-transcriptional mechanisms i …
However, dysfunctional induction of iNOS expression seems to be involved in the pathophysiology of several human diseases. The …
Post-transcriptional regulation of the human inducible nitric oxide synthase (iNOS) expression by the cytosolic poly(A)-binding protein (PABP).
Casper I, Nowag S, Koch K, Hubrich T, Bollmann F, Henke J, Schmitz K, Kleinert H, Pautz A. Casper I, et al. Nitric Oxide. 2013 Sep 1;33:6-17. doi: 10.1016/j.niox.2013.05.002. Epub 2013 May 25. Nitric Oxide. 2013. PMID: 23711718
Affinity purification using the 3'-untranslated region (3'-UTR) of the human inducible nitric oxide synthase (iNOS) mRNA identified the cytosolic poly(A)-binding protein (PABP) as a protein interacting with the human iNOS 3'-UTR. ...In summary, our dat …
Affinity purification using the 3'-untranslated region (3'-UTR) of the human inducible nitric oxide synthase (iNOS) mRNA ident …
Clonidine-induced enhancement of iNOS expression involves NF-kappaB.
Su NY, Tsai PS, Huang CJ. Su NY, et al. J Surg Res. 2008 Sep;149(1):131-7. doi: 10.1016/j.jss.2007.11.725. Epub 2008 Jan 10. J Surg Res. 2008. PMID: 18262561
Endotoxin-induced iNOS induction is regulated by nuclear factor-kappaB (NF-kappaB). Stability of iNOS mRNA is regulated by RNA stabilizing factor, e.g., Hu antigen R (HuR), and RNA destabilizing factors, e.g., AU-rich element/poly(U) binding fac …
Endotoxin-induced iNOS induction is regulated by nuclear factor-kappaB (NF-kappaB). Stability of iNOS mRNA is regulated by RNA …
NF-kappa B-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release.
Di Marco S, Mazroui R, Dallaire P, Chittur S, Tenenbaum SA, Radzioch D, Marette A, Gallouzi IE. Di Marco S, et al. Mol Cell Biol. 2005 Aug;25(15):6533-45. doi: 10.1128/MCB.25.15.6533-6545.2005. Mol Cell Biol. 2005. PMID: 16024790 Free PMC article.
Moreover, we show that HuR regulates iNOS expression in an AMP-activated protein kinase (AMPK)-dependent manner. Furthermore, AMPK activation results in HuR nuclear sequestration, inhibition of iNOS synthesis, and reduction in cytokine-induced MyoD los …
Moreover, we show that HuR regulates iNOS expression in an AMP-activated protein kinase (AMPK)-dependent manner. Furthermore, …
Impaired liver regeneration in mice lacking glycine N-methyltransferase.
Varela-Rey M, Fernández-Ramos D, Martínez-López N, Embade N, Gómez-Santos L, Beraza N, Vázquez-Chantada M, Rodríguez J, Luka Z, Wagner C, Lu SC, Martínez-Chantar ML, Mato JM. Varela-Rey M, et al. Hepatology. 2009 Aug;50(2):443-52. doi: 10.1002/hep.23033. Hepatology. 2009. PMID: 19582817 Free PMC article.
PH in GNMT-KO mice was followed by the inactivation of STAT3 phosphorylation and iNOS expression. NFkappaB, cyclin D1 and cyclin A were not further activated after PH. The LKB1/AMP-activated protein kinase/endothelial nitric oxide synthase cascade was inhibited, and cytopl …
PH in GNMT-KO mice was followed by the inactivation of STAT3 phosphorylation and iNOS expression. NFkappaB, cyclin D1 and cyclin A we …
Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis.
Murakami A, Furukawa I, Miyamoto S, Tanaka T, Ohigashi H. Murakami A, et al. Biofactors. 2013 Mar-Apr;39(2):221-32. doi: 10.1002/biof.1054. Epub 2012 Dec 11. Biofactors. 2013. PMID: 23233214
A chase experiment using actinomycin D revealed that ATM accelerated the decay of iNOS and COX-2 mRNA, suggesting a post-transcriptional mechanism. ATM prevented LPS-induced translocation of HuR, an AU-rich element-binding protein that determines mRNA stability of c …
A chase experiment using actinomycin D revealed that ATM accelerated the decay of iNOS and COX-2 mRNA, suggesting a post-transcriptio …
Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes.
Matsui K, Nishizawa M, Ozaki T, Kimura T, Hashimoto I, Yamada M, Kaibori M, Kamiyama Y, Ito S, Okumura T. Matsui K, et al. Hepatology. 2008 Feb;47(2):686-97. doi: 10.1002/hep.22036. Hepatology. 2008. PMID: 18161049
The iNOS mRNA colocalized with the AU-rich element-binding protein HuR, a human homolog of embryonic lethal-abnormal visual protein, and heterogeneous nuclear ribonucleoprotein L (hnRNP L) in the cytoplasm of rat hepatocytes. Interaction …
The iNOS mRNA colocalized with the AU-rich element-binding protein HuR, a human homolog of embryonic lethal
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