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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 1
2007 1
2008 1
2009 3
2010 4
2011 3
2013 3
2014 1
2015 2
2016 5
2017 5
2018 7
2019 10
2020 4
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46 results
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UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis.
Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, Wu X, Zhu H, Gao H, Liang J, Li G, Yang W. Wang X, et al. Nature. 2019 Jul;571(7763):127-131. doi: 10.1038/s41586-019-1340-y. Epub 2019 Jun 26. Nature. 2019. PMID: 31243371
Here we show that, after activation of EGFR, UGDH is phosphorylated at tyrosine 473 in human lung cancer cells. Phosphorylated UGDH interacts with Hu antigen R (HuR) and converts UDP-glucose to UDP-glucuronic acid, which attenuates the UD …
Here we show that, after activation of EGFR, UGDH is phosphorylated at tyrosine 473 in human lung cancer cells. Phospho …
Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA.
Wang M, Mao C, Ouyang L, Liu Y, Lai W, Liu N, Shi Y, Chen L, Xiao D, Yu F, Wang X, Zhou H, Cao Y, Liu S, Yan Q, Tao Y, Zhang B. Wang M, et al. Cell Death Differ. 2019 Nov;26(11):2329-2343. doi: 10.1038/s41418-019-0304-y. Epub 2019 Feb 20. Cell Death Differ. 2019. PMID: 30787392 Free PMC article.
Here we demonstrate that a nuclear lncRNA LINC00336 is upregulated in lung cancer and functions as an oncogene by acting as a competing endogenous RNA (ceRNAs). LINC00336 bound RNA-binding protein ELAVL1 (ELAV-like RNA-binding protein 1) using nucleoti …
Here we demonstrate that a nuclear lncRNA LINC00336 is upregulated in lung cancer and functions as an oncogene by acting as a …
Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin β1/FAK/ERK Signaling.
Wu JI, Lin YP, Tseng CW, Chen HJ, Wang LH. Wu JI, et al. Sci Rep. 2019 Jan 29;9(1):845. doi: 10.1038/s41598-018-37443-4. Sci Rep. 2019. PMID: 30696915 Free PMC article.
Increased Crabp2 levels have been found in various types of cancer, and are associated with poor patients' survival. Although Crabp2 is found to be overexpressed in lung cancer, its role in metastasis of lung cancer is unclear. ...Knockdown of C …
Increased Crabp2 levels have been found in various types of cancer, and are associated with poor patients' survival. Although Crabp2 …
Combinatorial Nanoparticle Delivery of siRNA and Antineoplastics for Lung Cancer Treatment.
Ahmed R, Amreddy N, Babu A, Munshi A, Ramesh R. Ahmed R, et al. Methods Mol Biol. 2019;1974:265-290. doi: 10.1007/978-1-4939-9220-1_20. Methods Mol Biol. 2019. PMID: 31099010
In this chapter, we provide detailed protocols for development and application of a multifunctional nanoparticle system for combinatorial delivery of a chemotherapeutic (cisplatin) and small interfering RNA (siRNA) for human antigen R (HuR) mRNA in …
In this chapter, we provide detailed protocols for development and application of a multifunctional nanoparticle system for combinatorial de …
The long intergenic non-protein coding RNA 707 promotes proliferation and metastasis of gastric cancer by interacting with mRNA stabilizing protein HuR.
Xie M, Ma T, Xue J, Ma H, Sun M, Zhang Z, Liu M, Liu Y, Ju S, Wang Z, De W. Xie M, et al. Cancer Lett. 2019 Feb 28;443:67-79. doi: 10.1016/j.canlet.2018.11.032. Epub 2018 Nov 29. Cancer Lett. 2019. PMID: 30502359
Multiple studies have revealed that long non-coding RNAs (lncRNAs) extensively participate in human cancer malignant progression. ...Mechanistically, LINC00707 could abundantly interact with mRNA stabilizing protein HuR; "LINC00707-HuR" coalition ulter …
Multiple studies have revealed that long non-coding RNAs (lncRNAs) extensively participate in human cancer malignant progressi …
Decreased human antigen R expression confers resistance to tyrosine kinase inhibitors in epidermal growth factor receptor-mutant lung cancer by inhibiting Bim expression.
Yao Y, Chu H, Wang J, Wang B. Yao Y, et al. Int J Mol Med. 2018 Nov;42(5):2930-2942. doi: 10.3892/ijmm.2018.3835. Epub 2018 Aug 22. Int J Mol Med. 2018. PMID: 30226552
Primary resistance to epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs) is an obstacle for the treatment of non‑small cell lung cancer (NSCLC); however, the associated mechanisms are not well understood. ...Human antigen R
Primary resistance to epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs) is an obstacle for the treatment of non‑small …
HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells.
Muralidharan R, Mehta M, Ahmed R, Roy S, Xu L, Aubé J, Chen A, Zhao YD, Herman T, Ramesh R, Munshi A. Muralidharan R, et al. Sci Rep. 2017 Aug 30;7(1):9694. doi: 10.1038/s41598-017-07787-4. Sci Rep. 2017. PMID: 28855578 Free PMC article.
Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer correlates with aggressive disease, drug resistance, and poor prognosis. ...In this study, we examined the antitumor activity of CMLD-2, a small-molecule inhibit
Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer correlates with aggre
Transcriptomic studies provide insights into the tumor suppressive role of miR-146a-5p in non-small cell lung cancer (NSCLC) cells.
Iacona JR, Monteleone NJ, Lemenze AD, Cornett AL, Lutz CS. Iacona JR, et al. RNA Biol. 2019 Dec;16(12):1721-1732. doi: 10.1080/15476286.2019.1657351. Epub 2019 Aug 23. RNA Biol. 2019. PMID: 31425002 Free PMC article.
Non-small cell lung cancer (NSCLC) is a complex disease in need of new methods of therapeutic intervention. Recent interest has focused on using microRNAs (miRNAs) as a novel treatment method for various cancers. miRNAs negatively regulate gene expression post-trans …
Non-small cell lung cancer (NSCLC) is a complex disease in need of new methods of therapeutic intervention. Recent interest ha …
Long non-coding RNA FENDRR attenuates the stemness of non-small cell lung cancer cells via decreasing multidrug resistance gene 1 (MDR1) expression through competitively binding with RNA binding protein HuR.
Gong F, Dong D, Zhang T, Xu W. Gong F, et al. Eur J Pharmacol. 2019 Jun 15;853:345-352. doi: 10.1016/j.ejphar.2019.04.022. Epub 2019 Apr 11. Eur J Pharmacol. 2019. PMID: 30981768
The roles of long non-coding RNA (lncRNA) FENDRR in non-small cell lung cancer (NSCLC) cells progression have never been revealed. ...We found that lncRNA FENDRR expression was significantly decreased in lung cancer tissues and cells, especially in NSC …
The roles of long non-coding RNA (lncRNA) FENDRR in non-small cell lung cancer (NSCLC) cells progression have never been revea …
MicroRNA-139-3p Inhibits The Growth And Metastasis Of Ovarian Cancer By Inhibiting ELAVL1.
Xue F, Li QR, Xu YH, Zhou HB. Xue F, et al. Onco Targets Ther. 2019 Nov 5;12:8935-8945. doi: 10.2147/OTT.S210739. eCollection 2019. Onco Targets Ther. 2019. PMID: 31806990 Free PMC article.
The proliferation, colony formation, migration and invasion of ovarian cancer cell were determined, respectively. A luciferase reporter assay was used to confirm ELAV Like RNA Binding Protein 1 (ELAVL1) was a target gene of miR-139-3p. ...Moreover, overexpres …
The proliferation, colony formation, migration and invasion of ovarian cancer cell were determined, respectively. A luciferase report …
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