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2008 1
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2011 4
2012 1
2013 1
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2018 2
2019 1
2020 0
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Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.
Frau M, Feo F, Pascale RM. Frau M, et al. J Hepatol. 2013 Oct;59(4):830-41. doi: 10.1016/j.jhep.2013.04.031. Epub 2013 May 7. J Hepatol. 2013. PMID: 23665184 Free article. Review.
In human HCC, MAT1A:MAT2A and MATI/III:MATII ratios correlate negatively with cell proliferation and genomic instability, and positively with apoptosis and global DNA methylation. ...Finally, MATI/III:MATII ratio strongly predicts patients' survival length suggesting that …
In human HCC, MAT1A:MAT2A and MATI/III:MATII ratios correlate negatively with cell proliferation and genomic instability, and positiv …
Decreased human antigen R expression confers resistance to tyrosine kinase inhibitors in epidermal growth factor receptor-mutant lung cancer by inhibiting Bim expression.
Yao Y, Chu H, Wang J, Wang B. Yao Y, et al. Int J Mol Med. 2018 Nov;42(5):2930-2942. doi: 10.3892/ijmm.2018.3835. Epub 2018 Aug 22. Int J Mol Med. 2018. PMID: 30226552
Human antigen R (HuR) regulates the mRNA and protein expression of target genes, including certain B‑cell lymphoma 2 family members. ...Therefore, altered HuR/Bim expression is proposed to be a novel mechanism of EGFR‑TKI resistance in NS
Human antigen R (HuR) regulates the mRNA and protein expression of target genes, including certain B‑cell lym
Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo.
Leucci E, Zriwil A, Gregersen LH, Jensen KT, Obad S, Bellan C, Leoncini L, Kauppinen S, Lund AH. Leucci E, et al. Oncogene. 2012 Dec 6;31(49):5081-9. doi: 10.1038/onc.2012.15. Epub 2012 Feb 6. Oncogene. 2012. PMID: 22310293
MicroRNAs are important regulators of gene expression in normal development and disease. miR-9 is overexpressed in several cancer forms, including brain tumours, hepatocellular carcinomas, breast cancer and Hodgkin lymphoma (HL). ...We show that inhibition of miR-9 leads t …
MicroRNAs are important regulators of gene expression in normal development and disease. miR-9 is overexpressed in several cancer forms, inc …
miR-291b-3p mediated ROS-induced endothelial cell dysfunction by targeting HUR.
Sui X, Yu S, Dou L, Chen X, Li X, Yang J, Su Y, Wang S, Wang F, Li J. Sui X, et al. Int J Mol Med. 2018 Nov;42(5):2383-2392. doi: 10.3892/ijmm.2018.3821. Epub 2018 Aug 10. Int J Mol Med. 2018. PMID: 30106126 Free PMC article.
The level of phosphorylated extracellular signal‑regulated kinase, and levels of B‑cell lymphoma 2 (Bcl‑2)‑associated X protein and Bcl‑2 protein were detected by western blot analysis. ...In addition, Hu antigen R (HuR) was identified as a target gene …
The level of phosphorylated extracellular signal‑regulated kinase, and levels of B‑cell lymphoma 2 (Bcl‑2)‑associated X protein and B …
HuR-mediated control of C/EBPbeta mRNA stability and translation in ALK-positive anaplastic large cell lymphomas.
Bergalet J, Fawal M, Lopez C, Desjobert C, Lamant L, Delsol G, Morello D, Espinos E. Bergalet J, et al. Mol Cancer Res. 2011 Apr;9(4):485-96. doi: 10.1158/1541-7786.MCR-10-0351. Epub 2011 Feb 22. Mol Cancer Res. 2011. PMID: 21343335 Free article.
The CCAAT/enhancer-binding protein β (C/EBPβ) plays a major role in the pathogenesis of anaplastic large cell lymphomas (ALCL) that express the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) tyrosine kinase (ALK(+)). ...By using human ALCL-derived cells and a mu …
The CCAAT/enhancer-binding protein β (C/EBPβ) plays a major role in the pathogenesis of anaplastic large cell lymphomas (ALCL) that express …
Genome-wide screening identifies oncofetal lncRNA Ptn-dt promoting the proliferation of hepatocellular carcinoma cells by regulating the Ptn receptor.
Huang JF, Jiang HY, Cai H, Liu Y, Zhu YQ, Lin SS, Hu TT, Wang TT, Yang WJ, Xiao B, Sun SH, Ma LY, Yin HR, Wang F. Huang JF, et al. Oncogene. 2019 May;38(18):3428-3445. doi: 10.1038/s41388-018-0643-z. Epub 2019 Jan 14. Oncogene. 2019. PMID: 30643194
RNA pulldown assay showed that Ptn-dt could interact with the HuR protein. Interestingly, miR-96 binds with HuR to maintain its stability as well. ...Meanwhile, previous studies have reported that Ptn can promote tumor growth and vascular abnormalization via anaplas …
RNA pulldown assay showed that Ptn-dt could interact with the HuR protein. Interestingly, miR-96 binds with HuR to maintain it …
Novel mRNA-containing cytoplasmic granules in ALK-transformed cells.
Fawal M, Jean-Jean O, Vanzo N, Morello D. Fawal M, et al. Mol Biol Cell. 2011 Mar 15;22(6):726-35. doi: 10.1091/mbc.E10-07-0569. Epub 2011 Jan 13. Mol Biol Cell. 2011. PMID: 21233286 Free PMC article.
In the present study, we have thoroughly characterized cytoplasmic foci, hereafter called AGs for ALK granules that form in transformed cells expressing the constitutively active anaplastic lymphoma kinase (ALK). AGs contain polyadenylated mRNAs and a unique combination of …
In the present study, we have thoroughly characterized cytoplasmic foci, hereafter called AGs for ALK granules that form in transformed cell …
Hepatitis C virus upregulates B-cell receptor signaling: a novel mechanism for HCV-associated B-cell lymphoproliferative disorders.
Dai B, Chen AY, Corkum CP, Peroutka RJ, Landon A, Houng S, Muniandy PA, Zhang Y, Lehrmann E, Mazan-Mamczarz K, Steinhardt J, Shlyak M, Chen QC, Becker KG, Livak F, Michalak TI, Talwani R, Gartenhaus RB. Dai B, et al. Oncogene. 2016 Jun 9;35(23):2979-90. doi: 10.1038/onc.2015.364. Epub 2015 Oct 5. Oncogene. 2016. PMID: 26434584 Free PMC article.
Increasing evidence indicates an association between chronic hepatitis C virus (HCV) infection and B-cell lymphoma, however, the mechanisms by which HCV causes B-cell lymphoproliferative disorder are still unclear. Herein, we demonstrate the expression of HCV viral protein …
Increasing evidence indicates an association between chronic hepatitis C virus (HCV) infection and B-cell lymphoma, however, the mech …
AU-rich RNA binding proteins in hematopoiesis and leukemogenesis.
Baou M, Norton JD, Murphy JJ. Baou M, et al. Blood. 2011 Nov 24;118(22):5732-40. doi: 10.1182/blood-2011-07-347237. Epub 2011 Sep 13. Blood. 2011. PMID: 21917750
Three distinct types of AU-rich RNA binding protein (ARE poly-U-binding degradation factor-1/AUF1, Hu antigen/HuR/HuA/ELAVL1, and the tristetraprolin/ZFP36 family of proteins) are essential for normal hematopoiesis. ...Studies of these diverse types of RNA bi …
Three distinct types of AU-rich RNA binding protein (ARE poly-U-binding degradation factor-1/AUF1, Hu antigen/HuR/HuA/ELAVL
PMA induces stabilization of oncostatin M mRNA in human lymphoma U937 cells.
Bandyopadhyay S, Sengupta TK, Spicer EK. Bandyopadhyay S, et al. Biochem J. 2008 Feb 15;410(1):177-86. doi: 10.1042/BJ20070311. Biochem J. 2008. PMID: 17924856
We have found that PMA treatment of human U937 lymphoma cells increased the steady-state levels of OSM mRNA. Furthermore, the half-life of OSM mRNA was increased from 2.3 to 6.2 h. ...RNA-decay assays indicated that HuR stabilizes OSM RNA in vitro. Additional …
We have found that PMA treatment of human U937 lymphoma cells increased the steady-state levels of OSM mRNA. Furthermore, the …
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