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2007 2
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2018 14
2019 19
2020 17
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METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer.
Yue B, Song C, Yang L, Cui R, Cheng X, Zhang Z, Zhao G. Yue B, et al. Mol Cancer. 2019 Oct 13;18(1):142. doi: 10.1186/s12943-019-1065-4. Mol Cancer. 2019. PMID: 31607270 Free PMC article.
METHODS: qRT-PCR and immunohistochemistry were used to evaluate the expression of methyltransferase-like 3 (METTL3) in gastric cancer (GC). ...The m6A modification of ZMYM1 mRNA by METTL3 enhanced its stability relying on the "reader" protein HuR (also known as E
METHODS: qRT-PCR and immunohistochemistry were used to evaluate the expression of methyltransferase-like 3 (METTL3) in gastric cancer …
UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis.
Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, Wu X, Zhu H, Gao H, Liang J, Li G, Yang W. Wang X, et al. Nature. 2019 Jul;571(7763):127-131. doi: 10.1038/s41586-019-1340-y. Epub 2019 Jun 26. Nature. 2019. PMID: 31243371
Phosphorylated UGDH interacts with Hu antigen R (HuR) and converts UDP-glucose to UDP-glucuronic acid, which attenuates the UDP-glucose-mediated inhibition of the association of HuR with SNAI1 mRNA and therefore enhances the stability of SNAI1 mRNA. .. …
Phosphorylated UGDH interacts with Hu antigen R (HuR) and converts UDP-glucose to UDP-glucuronic acid, which attenuates …
KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3.
Lan T, Li H, Zhang D, Xu L, Liu H, Hao X, Yan X, Liao H, Chen X, Xie K, Li J, Liao M, Huang J, Yuan K, Zeng Y, Wu H. Lan T, et al. Mol Cancer. 2019 Dec 19;18(1):186. doi: 10.1186/s12943-019-1106-z. Mol Cancer. 2019. PMID: 31856849 Free PMC article.
KIAA1429 induced m6A methylation on the 3' UTR of GATA3 pre-mRNA, leading to the separation of the RNA-binding protein HuR and the degradation of GATA3 pre-mRNA. ...Accordingly, we found that the tumor growth and metastasis driven by KIAA1429 or GATA3-AS were mediat …
KIAA1429 induced m6A methylation on the 3' UTR of GATA3 pre-mRNA, leading to the separation of the RNA-binding protein HuR and the de …
Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation.
Yang F, Hu A, Li D, Wang J, Guo Y, Liu Y, Li H, Chen Y, Wang X, Huang K, Zheng L, Tong Q. Yang F, et al. Mol Cancer. 2019 Nov 13;18(1):158. doi: 10.1186/s12943-019-1094-z. Mol Cancer. 2019. PMID: 31718709 Free PMC article.
Our previous study has identified that circAGO2 drives gastric cancer progression through activating human antigen R (HuR), a protein stabilizing AU-rich element-containing mRNAs. ...Ectopic expression of circ-HuR suppressed the growth, invasion …
Our previous study has identified that circAGO2 drives gastric cancer progression through activating human antigen R ( …
MiR-155-5p controls colon cancer cell migration via post-transcriptional regulation of Human Antigen R (HuR).
Al-Haidari A, Algaber A, Madhi R, Syk I, Thorlacius H. Al-Haidari A, et al. Cancer Lett. 2018 May 1;421:145-151. doi: 10.1016/j.canlet.2018.02.026. Epub 2018 Feb 20. Cancer Lett. 2018. PMID: 29471005
Metastasis is the worst prognostic factor for patients with CRC. HuR (ELAVL1) is overexpressed in CRC and has been reported to promote colon cancer growth by targeting RNA in the cell cytoplasm. ...Taken together, these novel findings demonstrate that AREs me
Metastasis is the worst prognostic factor for patients with CRC. HuR (ELAVL1) is overexpressed in CRC and has been repo
The long intergenic non-protein coding RNA 707 promotes proliferation and metastasis of gastric cancer by interacting with mRNA stabilizing protein HuR.
Xie M, Ma T, Xue J, Ma H, Sun M, Zhang Z, Liu M, Liu Y, Ju S, Wang Z, De W. Xie M, et al. Cancer Lett. 2019 Feb 28;443:67-79. doi: 10.1016/j.canlet.2018.11.032. Epub 2018 Nov 29. Cancer Lett. 2019. PMID: 30502359
Multiple studies have revealed that long non-coding RNAs (lncRNAs) extensively participate in human cancer malignant progression. ...In vitro and in vivo assays showed that LINC00707 promote GC cell proliferation and metastasis. Mechanistically, LINC00707 could abun …
Multiple studies have revealed that long non-coding RNAs (lncRNAs) extensively participate in human cancer malignant progression. ... …
Identification and Functional Characterization of Long Non-coding RNA MIR22HG as a Tumor Suppressor for Hepatocellular Carcinoma.
Zhang DY, Zou XJ, Cao CH, Zhang T, Lei L, Qi XL, Liu L, Wu DH. Zhang DY, et al. Theranostics. 2018 Jun 13;8(14):3751-3765. doi: 10.7150/thno.22493. eCollection 2018. Theranostics. 2018. PMID: 30083257 Free PMC article.
Forced expression of MIR22HG in HCC cells significantly suppressed proliferation, invasion, and metastasis in vitro and in vivo. ...Additionally, MIR22HG directly interacted with HuR and regulated its subcellular localization. MIR22HG competitively bound to human
Forced expression of MIR22HG in HCC cells significantly suppressed proliferation, invasion, and metastasis in vitro and in vivo. ...A …
Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes.
Chen Y, Yang F, Fang E, Xiao W, Mei H, Li H, Li D, Song H, Wang J, Hong M, Wang X, Huang K, Zheng L, Tong Q. Chen Y, et al. Cell Death Differ. 2019 Jul;26(7):1346-1364. doi: 10.1038/s41418-018-0220-6. Epub 2018 Oct 19. Cell Death Differ. 2019. PMID: 30341421 Free PMC article.
CircAGO2 promotes the growth, invasion, and metastasis of cancer cells in vitro and in vivo. Mechanistic studies reveal that circAGO2 physically interacts with human antigen R (HuR) protein to facilitate its activation and enrichment on the 3'-u …
CircAGO2 promotes the growth, invasion, and metastasis of cancer cells in vitro and in vivo. Mechanistic studies reveal that circAGO2 …
MicroRNA-139-3p Inhibits The Growth And Metastasis Of Ovarian Cancer By Inhibiting ELAVL1.
Xue F, Li QR, Xu YH, Zhou HB. Xue F, et al. Onco Targets Ther. 2019 Nov 5;12:8935-8945. doi: 10.2147/OTT.S210739. eCollection 2019. Onco Targets Ther. 2019. PMID: 31806990 Free PMC article.
A luciferase reporter assay was used to confirm ELAV Like RNA Binding Protein 1 (ELAVL1) was a target gene of miR-139-3p. The expression of ELAVL1 was detected using Western blotting and immunofluorescence staining assay. ...Furthermore, the expression of …
A luciferase reporter assay was used to confirm ELAV Like RNA Binding Protein 1 (ELAVL1) was a target gene of miR-139-3p. The …
Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrinbeta1/FAK/ERK Signaling.
Wu JI, Lin YP, Tseng CW, Chen HJ, Wang LH. Wu JI, et al. Sci Rep. 2019 Jan 29;9(1):845. doi: 10.1038/s41598-018-37443-4. Sci Rep. 2019. PMID: 30696915 Free PMC article.
Knockdown of Crabp2 decreased migration, invasion, anoikis resistance, and in vivo metastasis. Crabp2 was co-immunoprecipitated with HuR, and overexpression of Crabp2 increased HuR levels, which promoted integrinbeta1/FAK/ERK signaling. ...Knockdown of Crabp2 …
Knockdown of Crabp2 decreased migration, invasion, anoikis resistance, and in vivo metastasis. Crabp2 was co-immunoprecipitated with …
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