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Year Number of Results
2003 2
2005 1
2006 3
2007 3
2008 2
2009 4
2010 7
2011 3
2012 7
2013 2
2014 5
2015 3
2016 4
2017 7
2018 5
2019 3
2020 3
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Page 1
Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA.
Wang M, Mao C, Ouyang L, Liu Y, Lai W, Liu N, Shi Y, Chen L, Xiao D, Yu F, Wang X, Zhou H, Cao Y, Liu S, Yan Q, Tao Y, Zhang B. Wang M, et al. Cell Death Differ. 2019 Nov;26(11):2329-2343. doi: 10.1038/s41418-019-0304-y. Epub 2019 Feb 20. Cell Death Differ. 2019. PMID: 30787392 Free PMC article.
LINC00336 bound RNA-binding protein ELAVL1 (ELAV-like RNA-binding protein 1) using nucleotides 1901-2107 of LINC00336 and the RRM interaction domain and key amino acids (aa) of ELAVL1 (aa 101-213), inhibiting ferroptosis. Moreover, ELAVL1 increased LIN …
LINC00336 bound RNA-binding protein ELAVL1 (ELAV-like RNA-binding protein 1) using nucleotides 1901-2107 of LINC00336 and the …
RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells.
Zhang Z, Guo M, Li Y, Shen M, Kong D, Shao J, Ding H, Tan S, Chen A, Zhang F, Zheng S. Zhang Z, et al. Autophagy. 2020 Aug;16(8):1482-1505. doi: 10.1080/15548627.2019.1687985. Epub 2019 Nov 11. Autophagy. 2020. PMID: 31679460
Attractively, sorafenib monotherapy led to ZFP36 downregulation, ferritinophagy activation, and ferroptosis induction in human HSCs. ...ABBREVIATIONS: ARE: AU-rich elements; ATG: autophagy related; BECN1: beclin 1; CHX: cycloheximide; COL1A1: collagen type I alpha 1 chain; …
Attractively, sorafenib monotherapy led to ZFP36 downregulation, ferritinophagy activation, and ferroptosis induction in human HSCs. …
Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer.
Li XL, Subramanian M, Jones MF, Chaudhary R, Singh DK, Zong X, Gryder B, Sindri S, Mo M, Schetter A, Wen X, Parvathaneni S, Kazandjian D, Jenkins LM, Tang W, Elloumi F, Martindale JL, Huarte M, Zhu Y, Robles AI, Frier SM, Rigo F, Cam M, Ambs S, Sharma S, Harris CC, Dasso M, Prasanth KV, Lal A. Li XL, et al. Cell Rep. 2017 Sep 5;20(10):2408-2423. doi: 10.1016/j.celrep.2017.08.041. Cell Rep. 2017. PMID: 28877474 Free PMC article.
Here, we report the suppression of basal p53 levels by a nuclear, p53-regulated long noncoding RNA that we termed PURPL (p53 upregulated regulator of p53 levels). ...PURPL associates with MYBBP1A, a protein that binds to and stabilizes p53, and …
Here, we report the suppression of basal p53 levels by a nuclear, p53-regulated long noncoding RNA that we termed PURPL (p5
Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 Under DNA Damage.
Guha A, Ahuja D, Das Mandal S, Parasar B, Deyasi K, Roy D, Sharma V, Willard B, Ghosh A, Ray PS. Guha A, et al. iScience. 2019 May 31;15:342-359. doi: 10.1016/j.isci.2019.05.002. Epub 2019 May 4. iScience. 2019. PMID: 31103853 Free PMC article.
The RNA-binding protein HuR activates p53 mRNA translation in response to UVC-induced DNA damage in breast carcinoma cells. p53 and HuR levels show pulsatile change post UV irradiation. The computed model fitted with the observed pulse of p53 an …
The RNA-binding protein HuR activates p53 mRNA translation in response to UVC-induced DNA damage in breast carcinoma cells. …
Progress on the relationship between miR-125 family and tumorigenesis.
Yin H, Sun Y, Wang X, Park J, Zhang Y, Li M, Yin J, Liu Q, Wei M. Yin H, et al. Exp Cell Res. 2015 Dec 10;339(2):252-60. doi: 10.1016/j.yexcr.2015.09.015. Epub 2015 Sep 25. Exp Cell Res. 2015. PMID: 26407906 Review.
The downstream targets of miRNA-125 include transcription factors like STAT3, cytokines like IL-6 and TGF-β, tumor suppressing protein p53, pro-apoptotic protein Bak1 and RNA binding protein HuR et al. ...
The downstream targets of miRNA-125 include transcription factors like STAT3, cytokines like IL-6 and TGF-β, tumor suppressing …
Viral Apoptosis Evasion via the MAPK Pathway by Use of a Host Long Noncoding RNA.
Barichievy S, Naidoo J, Boullé M, Scholefield J, Parihar SP, Coussens AK, Brombacher F, Sigal A, Mhlanga MM. Barichievy S, et al. Front Cell Infect Microbiol. 2018 Aug 3;8:263. doi: 10.3389/fcimb.2018.00263. eCollection 2018. Front Cell Infect Microbiol. 2018. PMID: 30123777 Free PMC article.
The Human Immunodeficiency Virus type 1 (HIV-1) is one such pathogen as it induces apoptosis in CD4+ T cells but is largely non-cytopathic in macrophages. ...Apoptosis is triggered by double-strand breaks (DSBs), such as those induced by integrating retroviruses like
The Human Immunodeficiency Virus type 1 (HIV-1) is one such pathogen as it induces apoptosis in CD4+ T cells but is largely non-cytop …
Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities.
Su SC, Lin CW, Liu YF, Fan WL, Chen MK, Yu CP, Yang WE, Su CW, Chuang CY, Li WH, Chung WH, Yang SF. Su SC, et al. Theranostics. 2017 Feb 26;7(5):1088-1099. doi: 10.7150/thno.18551. eCollection 2017. Theranostics. 2017. PMID: 28435450 Free PMC article.
In addition, known (TP53, FAT1, EPHA2, CDKN2A, NOTCH1, CASP8, HRAS, RASA1, and PIK3CA) and novel (CHUK and ELAVL1) genes that were significantly and frequently mutated in OSCC were discovered. ...Strikingly, if targeting the p53-cell cycle pathway (TP53 and CCND1) b …
In addition, known (TP53, FAT1, EPHA2, CDKN2A, NOTCH1, CASP8, HRAS, RASA1, and PIK3CA) and novel (CHUK and ELAVL1) genes that were si …
Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress.
Ahuja D, Goyal A, Ray PS. Ahuja D, et al. RNA Biol. 2016 Nov;13(11):1152-1165. doi: 10.1080/15476286.2016.1229734. Epub 2016 Sep 3. RNA Biol. 2016. PMID: 27592685 Free PMC article.
The AU/U-rich element-binding protein HuR has been shown to bind to p53 mRNA 3'UTR and enhance translation in response to DNA-damaging UVC radiation. ...Binding of HuR to the p53 mRNA 3'UTR, especially at a site adjacent to the miR-125b target site, ca …
The AU/U-rich element-binding protein HuR has been shown to bind to p53 mRNA 3'UTR and enhance translation in response to DNA- …
Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation.
Nakamura H, Kawagishi H, Watanabe A, Sugimoto K, Maruyama M, Sugimoto M. Nakamura H, et al. Mol Cell Biol. 2011 May;31(10):1997-2009. doi: 10.1128/MCB.01424-10. Epub 2011 Mar 14. Mol Cell Biol. 2011. PMID: 21402775 Free PMC article.
We show here that Hzf regulates p53 expression in cooperation with HuR. Hzf and HuR independently interact with the 3' untranslated region (UTR) of p53 mRNA, which facilitates the cytoplasmic localization of p53 mRNA in the presence of the ARF t …
We show here that Hzf regulates p53 expression in cooperation with HuR. Hzf and HuR independently interact with the 3' …
Genome-scale functional analysis of the human genes modulating p53 activity by regulating MDM2 expression in a p53-independent manner.
Kim DM, Choi SH, Yeom YI, Min SH, Kim IC. Kim DM, et al. Biochem Biophys Res Commun. 2016 Sep 16;478(2):976-81. doi: 10.1016/j.bbrc.2016.08.063. Epub 2016 Aug 11. Biochem Biophys Res Commun. 2016. PMID: 27524244
Therefore, we performed genome-scale functional screening of the human genes modulating MDM2 expression in a p53-independent manner. ...Among them, six clones, including NTRK2, GNA15, SFRS2, EIF5A, ELAVL1, and YWHAB mediated MAPK signaling for expressing MDM2 …
Therefore, we performed genome-scale functional screening of the human genes modulating MDM2 expression in a p53-independent m …
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