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Four-weekly Low-dose Gemcitabine and Paclitaxel in Patients With Platinum-resistant Urothelial Cancer and Performance Status 2/3.
Araki K, Miyata Y, Nakamura Y, Mukae Y, Otsubo A, Yuno T, Mitsunari K, Matsuo T, Ohba K, Sakai H. Araki K, et al. In Vivo. 2019 Nov-Dec;33(6):2217-2224. doi: 10.21873/invivo.11725. In Vivo. 2019. PMID: 31662559 Free PMC article.
The aim of this study was to assess the safety and usefulness of combined therapy with low-dose gemcitabine and paclitaxel every 4 weeks. PATIENTS AND METHODS: Thirty patients were treated with gemcitabine (700 mg/m(2) on day 1) and paclitaxel (70 mg/m(2) on day 1) …
The aim of this study was to assess the safety and usefulness of combined therapy with low-dose gemcitabine and paclitaxel every 4 we …
Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells.
Badawi A, Biyanee A, Nasrullah U, Winslow S, Schmid T, Pfeilschifter J, Eberhardt W. Badawi A, et al. Oncotarget. 2018 Apr 6;9(26):18367-18385. doi: 10.18632/oncotarget.24840. eCollection 2018 Apr 6. Oncotarget. 2018. PMID: 29719611 Free PMC article.
In accordance with the significant drug-induced increase in cytoplasmic HuR abundance, doxorubicin and paclitaxel increased the interaction of cytoplasmic HuR with the 5'untranslated region (5'UTR) of caspase-2 as shown by RNA pull down assay. ...Luciferase a …
In accordance with the significant drug-induced increase in cytoplasmic HuR abundance, doxorubicin and paclitaxel increased th …
Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma.
Janakiraman H, House RP, Talwar S, Courtney SM, Hazard ES, Hardiman G, Mehrotra S, Howe PH, Gangaraju V, Palanisamy V. Janakiraman H, et al. Oncogene. 2017 Jun 1;36(22):3137-3148. doi: 10.1038/onc.2016.451. Epub 2016 Dec 12. Oncogene. 2017. PMID: 27941877 Free PMC article.
A well-studied RNA-binding protein Hu Antigen-R (HuR), controls post-transcriptional gene regulation and undergoes stress-activated caspase-3 dependent cleavage in cancer cells. ...Here, we show that HuR cleavage associated with active caspase-3 in ora …
A well-studied RNA-binding protein Hu Antigen-R (HuR), controls post-transcriptional gene regulation and undergoes stre …
Human antigen R as a predictive marker for response to gemcitabine-based chemotherapy in advanced cisplatin-resistant urothelial cancer.
Miyata Y, Mitsunari K, Akihiro A, Watanabe SI, Matsuo T, Ohba K, Sakai H. Miyata Y, et al. Oncol Lett. 2017 Feb;13(2):811-818. doi: 10.3892/ol.2016.5484. Epub 2016 Dec 12. Oncol Lett. 2017. PMID: 28356963 Free PMC article.
Although no standard regime for the treatment of CDDP-resistant UC has been established, GEM-based regimens are frequently used in these patients. In other types of cancer, human antigen R (HuR) status in cancer cells is closely associated with patient …
Although no standard regime for the treatment of CDDP-resistant UC has been established, GEM-based regimens are frequently used in these pat …
Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy.
Wang J, Li D, Wang B, Wu Y. Wang J, et al. Breast Cancer Res Treat. 2013 Sep;141(2):213-24. doi: 10.1007/s10549-013-2679-7. Epub 2013 Sep 14. Breast Cancer Res Treat. 2013. PMID: 24036660
Cytoplasmic HuR is associated with reduced survival in invasive breast cancer. ...We immunohistochemically analyzed cytoplasmic HuR expression in tumor biopsy cores obtained from 139 patients with invasive breast cancers who received paclitaxel and anthracycl …
Cytoplasmic HuR is associated with reduced survival in invasive breast cancer. ...We immunohistochemically analyzed cytoplasmic Hu
MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms.
Kojima K, Fujita Y, Nozawa Y, Deguchi T, Ito M. Kojima K, et al. Prostate. 2010 Oct 1;70(14):1501-12. doi: 10.1002/pros.21185. Prostate. 2010. PMID: 20687223
METHODS: Paclitaxel-resistant cells (PC3PR) were generated from hormone-refractory PC3 cells. ...RESULTS: MiR-34a over-expression and SIRT1 knockdown attenuated paclitaxel resistance of PC3PR cells. MiR-34a expression was reduced in PC3PR cells compared with PC3 cel …
METHODS: Paclitaxel-resistant cells (PC3PR) were generated from hormone-refractory PC3 cells. ...RESULTS: MiR-34a over-expression and …
Advantages of Using Paclitaxel in Combination with Oncolytic Adenovirus Utilizing RNA Destabilization Mechanism.
Hossain E, Habiba U, Yanagawa-Matsuda A, Alam A, Ahmed I, Alam MT, Yasuda M, Higashino F. Hossain E, et al. Cancers (Basel). 2020 May 12;12(5):1210. doi: 10.3390/cancers12051210. Cancers (Basel). 2020. PMID: 32408515 Free PMC article.
In this study, we examined the oncolytic activity of Ad-fosARE and used it in a synergistic combination with the chemotherapeutic agent paclitaxel (PTX) for treating cancer cells. The expression of E1A was high in cancer cells due to stabilized E1A-ARE mRNA. As a result, t …
In this study, we examined the oncolytic activity of Ad-fosARE and used it in a synergistic combination with the chemotherapeutic agent p
Regulation of cyclooxgenase-2 mRNA stability by taxanes: evidence for involvement of p38, MAPKAPK-2, and HuR.
Subbaramaiah K, Marmo TP, Dixon DA, Dannenberg AJ. Subbaramaiah K, et al. J Biol Chem. 2003 Sep 26;278(39):37637-47. doi: 10.1074/jbc.M301481200. Epub 2003 Jun 25. J Biol Chem. 2003. PMID: 12826679 Free article. Retracted.
Taxanes are widely used to treat malignancies and are known to modulate the transcription of several genes. We investigated the effects of taxanes (docetaxel and paclitaxel) on cyclooxygenase-2 (COX-2) transcription and mRNA stability in human mammary epithelial cel …
Taxanes are widely used to treat malignancies and are known to modulate the transcription of several genes. We investigated the effects of t …
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