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2020 0
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Two in-and-out modulation strategies for endoplasmic reticulum stress-linked gene expression of pro-apoptotic macrophage-inhibitory cytokine 1.
Park SH, Choi HJ, Yang H, Do KH, Kim J, Kim HH, Lee H, Oh CG, Lee DW, Moon Y. Park SH, et al. J Biol Chem. 2012 Jun 8;287(24):19841-55. doi: 10.1074/jbc.M111.330639. Epub 2012 Apr 17. J Biol Chem. 2012. PMID: 22511768 Free PMC article.
To investigate the precise molecular mechanisms of MIC-1 gene regulation, ER stress and its related signals were studied in human colon cancer cells. ...First, C/EBP homologous protein triggered protein kinase C-linked cytosolic translocation of the HuR
To investigate the precise molecular mechanisms of MIC-1 gene regulation, ER stress and its related signals were studied in human col …
HUB1, a novel Krüppel type zinc finger protein, represses the human T cell leukemia virus type I long terminal repeat-mediated expression.
Okumura K, Sakaguchi G, Naito K, Tamura T, Igarashi H. Okumura K, et al. Nucleic Acids Res. 1997 Dec 15;25(24):5025-32. doi: 10.1093/nar/25.24.5025. Nucleic Acids Res. 1997. PMID: 9396811 Free PMC article.
Screening 2 x10(6) clones gave a positive clone with a 3.8 kb insert encoding a novel 671 residue polypeptide, named HTLV-I U5RE binding protein 1 (HUB1), with five zinc finger domains and a Krüppel-associated box like domain; HUB1 may be related to a repressor belo …
Screening 2 x10(6) clones gave a positive clone with a 3.8 kb insert encoding a novel 671 residue polypeptide, named HTLV-I U5RE binding …
AsSIRTing the DNA damage response.
Gorospe M, de Cabo R. Gorospe M, et al. Trends Cell Biol. 2008 Feb;18(2):77-83. doi: 10.1016/j.tcb.2007.11.007. Epub 2008 Jan 22. Trends Cell Biol. 2008. PMID: 18215521 Review.
The RNA-binding protein HuR associates with sirtuin (SIRT)1 mRNA and maintains constitutively elevated levels of SIRT1 protein, a deacetylase that elicits a prosurvival function. SIRT1 was recently shown to deacetylate the Nijmegen breakage syndrome (NBS1) …
The RNA-binding protein HuR associates with sirtuin (SIRT)1 mRNA and maintains constitutively elevated levels of SIRT1 prot
Tissue distribution of AU-rich mRNA-binding proteins involved in regulation of mRNA decay.
Lu JY, Schneider RJ. Lu JY, et al. J Biol Chem. 2004 Mar 26;279(13):12974-9. doi: 10.1074/jbc.M310433200. Epub 2004 Jan 7. J Biol Chem. 2004. PMID: 14711832 Free article.
We show that HuR protein, a major AUBP that stabilizes the ARE mRNAs, is most strongly expressed in the thymus, spleen (predominantly in lymphocytic cells), intestine, and testes. ...KH-type splicing regulatory protein, a presumptive negative regulator of ARE …
We show that HuR protein, a major AUBP that stabilizes the ARE mRNAs, is most strongly expressed in the thymus, spleen (predom …
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