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Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease.
Sun K, Li X, Chen X, Bai Y, Zhou G, Kokiko-Cochran ON, Lamb B, Hamilton TA, Lin CY, Lee YS, Herjan T. Sun K, et al. J Immunol. 2018 Jul 1;201(1):157-166. doi: 10.4049/jimmunol.1701501. Epub 2018 May 14. J Immunol. 2018. PMID: 29760195 Free PMC article.
Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. ...After tamoxifen-induced deletion of HuR, these mice developed a phenotype consisting of poor balance, decreased movement, and decreased strength. ...
Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. ...After tamoxifen-induced deletion of
Smooth muscle-specific Gsα deletion exaggerates angiotensin II-induced abdominal aortic aneurysm formation in mice in vivo.
Qin X, He L, Tian M, Hu P, Yang J, Lu H, Chen W, Jiang X, Zhang C, Gao J, Chen M, Weinstein LS, Zhang Y, Zhang W. Qin X, et al. J Mol Cell Cardiol. 2019 Jul;132:49-59. doi: 10.1016/j.yjmcc.2019.05.002. Epub 2019 May 7. J Mol Cell Cardiol. 2019. PMID: 31071332 Free PMC article.
Mechanically, Gsalpha deletion reduced cAMP level and increased the level of human antigen R (HuR), which binds with the adenylate uridylate-rich elements of the 3' untranslated region of Kruppel-like factor 4 (KLF4) mRNA, thereby increasing the …
Mechanically, Gsalpha deletion reduced cAMP level and increased the level of human antigen R (HuR), which binds …
Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells.
Tan S, Ding K, Chong QY, Zhao J, Liu Y, Shao Y, Zhang Y, Yu Q, Xiong Z, Zhang W, Zhang M, Li G, Li X, Kong X, Ahmad A, Wu Z, Wu Q, Zhao X, Lobie PE, Zhu T. Tan S, et al. J Biol Chem. 2017 Aug 18;292(33):13551-13564. doi: 10.1074/jbc.M117.780973. Epub 2017 Jun 21. J Biol Chem. 2017. PMID: 28637868 Free PMC article.
Herein, we reported that the ERBB2 expression is regulated at the post-transcriptional level by miR26a/b and the RNA-binding protein human antigen R (HuR), both of which associate with the 3'-UTR of the ERBB2 transcripts. ...In contrast, the inactivati …
Herein, we reported that the ERBB2 expression is regulated at the post-transcriptional level by miR26a/b and the RNA-binding protein huma
Timing is everything: order of administration of 5-aza 2' deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity.
Hostetter CL, Licata LA, Keen JC. Hostetter CL, et al. Cancer Lett. 2009 Mar 18;275(2):178-84. doi: 10.1016/j.canlet.2008.10.005. Epub 2008 Nov 13. Cancer Lett. 2009. PMID: 19013015
Treatment with AZA followed by co-administration of TSA plus tamoxifen resulted in the greatest ER re-expression and tamoxifen sensitivity, although sensitivity was not increased as robustly as expected. This could be due to increased cytoplasmic levels of HuR
Treatment with AZA followed by co-administration of TSA plus tamoxifen resulted in the greatest ER re-expression and tamoxifen
Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells.
Hostetter C, Licata LA, Witkiewicz A, Costantino CL, Yeo CJ, Brody JR, Keen JC. Hostetter C, et al. Cancer Biol Ther. 2008 Sep;7(9):1496-506. doi: 10.4161/cbt.7.9.6490. Epub 2008 Sep 23. Cancer Biol Ther. 2008. PMID: 18769129
Therefore, we tested the effect of HuR expression on tamoxifen responsiveness in both tamoxifen sensitive MCF7 and tamoxifen resistant BT474 cell lines. ...Conversely, the overexpression of HuR establishes tamoxifen resistance in MCF7 cel …
Therefore, we tested the effect of HuR expression on tamoxifen responsiveness in both tamoxifen sensitive MCF7 and t