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Year Number of Results
1997 1
1998 1
2002 1
2004 2
2005 1
2006 6
2007 5
2008 3
2009 3
2010 7
2011 2
2012 3
2013 1
2014 4
2015 4
2016 3
2017 2
2018 5
2019 1
2020 2
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Page 1
RNA-Binding Proteins in the Control of LPS-Induced Macrophage Response.
Ostareck DH, Ostareck-Lederer A. Ostareck DH, et al. Front Genet. 2019 Feb 4;10:31. doi: 10.3389/fgene.2019.00031. eCollection 2019. Front Genet. 2019. PMID: 30778370 Free PMC article. Review.
Innate immune response is triggered by pathogen components, like lipopolysaccharides (LPS) of gram-negative bacteria. LPS initiates Toll-like receptor 4 (TLR4) signaling, which involves mitogen activated protein kinases (MAPK) and nuclear factor kappa B (NFκB) in di …
Innate immune response is triggered by pathogen components, like lipopolysaccharides (LPS) of gram-negative bacteria. LPS initiates T …
T-Cell Intracellular Antigens and Hu Antigen R Antagonistically Modulate Mitochondrial Activity and Dynamics by Regulating Optic Atrophy 1 Gene Expression.
Carrascoso I, Alcalde J, Sánchez-Jiménez C, González-Sánchez P, Izquierdo JM. Carrascoso I, et al. Mol Cell Biol. 2017 Aug 11;37(17):e00174-17. doi: 10.1128/MCB.00174-17. Print 2017 Sep 1. Mol Cell Biol. 2017. PMID: 28630277 Free PMC article.
We show here that T-cell intracellular antigens (TIA1b/TIARb) and Hu antigen R (HuR) have antagonistic roles in mitochondrial function by modulating the expression of mitochondrial shaping proteins. ...In contrast, HuR expression promotes …
We show here that T-cell intracellular antigens (TIA1b/TIARb) and Hu antigen R (HuR) have antagonistic ro …
Viral Apoptosis Evasion via the MAPK Pathway by Use of a Host Long Noncoding RNA.
Barichievy S, Naidoo J, Boullé M, Scholefield J, Parihar SP, Coussens AK, Brombacher F, Sigal A, Mhlanga MM. Barichievy S, et al. Front Cell Infect Microbiol. 2018 Aug 3;8:263. doi: 10.3389/fcimb.2018.00263. eCollection 2018. Front Cell Infect Microbiol. 2018. PMID: 30123777 Free PMC article.
The Human Immunodeficiency Virus type 1 (HIV-1) is one such pathogen as it induces apoptosis in CD4+ T cells but is largely non-cytopathic in macrophages. ...Of particular note, this MAP2K1/ERK2 pro-survival cascade is switched off during T cell matura …
The Human Immunodeficiency Virus type 1 (HIV-1) is one such pathogen as it induces apoptosis in CD4+ T cells but is largely no …
Divergent Innate and Epithelial Functions of the RNA-Binding Protein HuR in Intestinal Inflammation.
Christodoulou-Vafeiadou E, Ioakeimidis F, Andreadou M, Giagkas G, Stamatakis G, Reczko M, Samiotaki M, Papanastasiou AD, Karakasiliotis I, Kontoyiannis DL. Christodoulou-Vafeiadou E, et al. Front Immunol. 2018 Nov 23;9:2732. doi: 10.3389/fimmu.2018.02732. eCollection 2018. Front Immunol. 2018. PMID: 30532756 Free PMC article.
HuR is an abundant RNA-binding protein acting as a post-transcriptional regulator of many RNAs including mRNAs encoding inflammatory mediators, cytokines, death signalers and cell cycle regulators. ...These mice were compared for their responses to (a) Chemically in
HuR is an abundant RNA-binding protein acting as a post-transcriptional regulator of many RNAs including mRNAs encoding inflammatory
T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K.
Rao GK, Wong A, Collinge M, Sarhan J, Yarovinsky TO, Ramgolam VS, Gaestel M, Pardi R, Bender JR. Rao GK, et al. PLoS One. 2018 Jul 26;13(7):e0201103. doi: 10.1371/journal.pone.0201103. eCollection 2018. PLoS One. 2018. PMID: 30048492 Free PMC article.
Activation of the β2 integrin lymphocyte function-associated antigen-1 (LFA-1) in T cells induces stabilization of proinflammatory AU-rich element (ARE)-bearing mRNAs, by triggering the nuclear-to-cytoplasmic translocation of the mRNA-binding and -stabilizing protei …
Activation of the β2 integrin lymphocyte function-associated antigen-1 (LFA-1) in T cells induces stabilization of proinflamma …
B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo.
DeMicco A, Naradikian MS, Sindhava VJ, Yoon JH, Gorospe M, Wertheim GB, Cancro MP, Bassing CH. DeMicco A, et al. J Immunol. 2015 Oct 1;195(7):3449-62. doi: 10.4049/jimmunol.1500512. Epub 2015 Aug 28. J Immunol. 2015. PMID: 26320247 Free PMC article.
This failure of HuRΔ/Δ mice to mount a T cell-dependent Ab response contrasts with the ability of HuRΔ/Δ B cells to become GC-like in vitro, indicating that HuR is essential for aspects of B cell activation unique to the in vivo environment. ... …
This failure of HuRΔ/Δ mice to mount a T cell-dependent Ab response contrasts with the ability of HuRΔ/Δ B cells to become GC- …
Expression of TNF-alpha, tristetraprolin, T-cell intracellular antigen-1 and Hu antigen R genes in synovium of patients with rheumatoid arthritis.
Suzuki E, Tsutsumi A, Sugihara M, Mamura M, Goto D, Matsumoto I, Ito S, Ikeda K, Ochiai N, Sato Y, Sumida T. Suzuki E, et al. Int J Mol Med. 2006 Aug;18(2):273-8. Int J Mol Med. 2006. PMID: 16820934
We measured the gene expression of ARBPs, including tristetraprolin, T-cell intracellular antigen (TIA)-1 and Hu antigen R (HuR), in synovial tissues from RA and osteoarthritis patients. cDNA was constructed from synovial tissues obtained …
We measured the gene expression of ARBPs, including tristetraprolin, T-cell intracellular antigen (TIA)-1 and Hu ant
Functional coordination and HuR-mediated regulation of mRNA stability during T cell activation.
Blackinton JG, Keene JD. Blackinton JG, et al. Nucleic Acids Res. 2016 Jan 8;44(1):426-36. doi: 10.1093/nar/gkv1066. Epub 2015 Oct 20. Nucleic Acids Res. 2016. PMID: 26490963 Free PMC article.
These mRNAs clustered into functionally related subpopulations that included replicative histones, ribosomal biogenesis and cell motility functions. ...This analysis demonstrated robust stabilization of mRNAs by the HuR RNA-binding protein 4 h after activation. Our …
These mRNAs clustered into functionally related subpopulations that included replicative histones, ribosomal biogenesis and cell moti …
Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1).
Wigington CP, Jung J, Rye EA, Belauret SL, Philpot AM, Feng Y, Santangelo PJ, Corbett AH. Wigington CP, et al. J Biol Chem. 2015 Feb 6;290(6):3468-87. doi: 10.1074/jbc.M114.631937. Epub 2014 Dec 17. J Biol Chem. 2015. PMID: 25519906 Free PMC article.
Post-transcriptional processing of mRNA transcripts plays a critical role in establishing the gene expression profile of a cell. ...Here, we provide evidence for post-transcriptional regulation of PDCD4 by the RNA-binding proteins, HuR and TIA1. Complementary approa …
Post-transcriptional processing of mRNA transcripts plays a critical role in establishing the gene expression profile of a cell. ...H …
LFA-1-dependent HuR nuclear export and cytokine mRNA stabilization in T cell activation.
Wang JG, Collinge M, Ramgolam V, Ayalon O, Fan XC, Pardi R, Bender JR. Wang JG, et al. J Immunol. 2006 Feb 15;176(4):2105-13. doi: 10.4049/jimmunol.176.4.2105. J Immunol. 2006. PMID: 16455966 Free article.
Abrogation of HuR function by use of inhibitory peptides, or marked reduction of HuR levels by RNA interference, prevents LFA-1 engagement-mediated stabilization of T cell TNF-alpha or IFN-gamma transcripts, respectively. Thus, HuR-mediated mRNA …
Abrogation of HuR function by use of inhibitory peptides, or marked reduction of HuR levels by RNA interference, prevents LFA- …
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