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WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1.
Chen Y, Peng C, Chen J, Chen D, Yang B, He B, Hu W, Zhang Y, Liu H, Dai L, Xie H, Zhou L, Wu J, Zheng S. Chen Y, et al. Mol Cancer. 2019 Aug 22;18(1):127. doi: 10.1186/s12943-019-1053-8. Mol Cancer. 2019. PMID: 31438961 Free PMC article.
The m6A modification regulated by WTAP led to post-transcriptional suppression of ETS1, with the implication of Hu-Antigen R (HuR) as an RNA stabilizer. Then ETS1 was found to inhibit the progression of HCC and could rescue the phenotype induced by WTAP defic …
The m6A modification regulated by WTAP led to post-transcriptional suppression of ETS1, with the implication of Hu-Antigen R ( …
KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3.
Lan T, Li H, Zhang D, Xu L, Liu H, Hao X, Yan X, Liao H, Chen X, Xie K, Li J, Liao M, Huang J, Yuan K, Zeng Y, Wu H. Lan T, et al. Mol Cancer. 2019 Dec 19;18(1):186. doi: 10.1186/s12943-019-1106-z. Mol Cancer. 2019. PMID: 31856849 Free PMC article.
KIAA1429 induced m6A methylation on the 3' UTR of GATA3 pre-mRNA, leading to the separation of the RNA-binding protein HuR and the degradation of GATA3 pre-mRNA. Strikingly, a long noncoding RNA (lncRNA) GATA3-AS, transcribed from the antisense strand of the GATA3 gene, fu …
KIAA1429 induced m6A methylation on the 3' UTR of GATA3 pre-mRNA, leading to the separation of the RNA-binding protein HuR and the de …
Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.
Frau M, Feo F, Pascale RM. Frau M, et al. J Hepatol. 2013 Oct;59(4):830-41. doi: 10.1016/j.jhep.2013.04.031. Epub 2013 May 7. J Hepatol. 2013. PMID: 23665184 Free article. Review.
Downregulation of liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and upregulation of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatocellular carcinoma (HCC). ...Finally, MATI/III: …
Downregulation of liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and upregulation of …
Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR.
Liu H, Lan T, Li H, Xu L, Chen X, Liao H, Chen X, Du J, Cai Y, Wang J, Li X, Huang J, Yuan K, Zeng Y. Liu H, et al. Theranostics. 2021 Jan 1;11(3):1396-1411. doi: 10.7150/thno.53227. eCollection 2021. Theranostics. 2021. PMID: 33391541 Free PMC article.
Mechanistic investigations revealed that circDLC1 could bind to RNA-binding protein HuR, which subsequently reduced the interaction between HuR and MMP1 mRNAs, and thus inhibited the expression of MMP1, ultimately contributing to inhibition of HCC progression. Concl …
Mechanistic investigations revealed that circDLC1 could bind to RNA-binding protein HuR, which subsequently reduced the interaction b …
Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy.
Mahpour A, Mullen AC. Mahpour A, et al. JHEP Rep. 2020 Sep 3;3(1):100177. doi: 10.1016/j.jhepr.2020.100177. eCollection 2021 Feb. JHEP Rep. 2020. PMID: 33294829 Free PMC article. Review.
New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, and malignancy, including hepatocellular carcinoma and cholangiocarcinoma. In this review, we summarise our current understanding of the fun …
New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, …
Human antigen R: A potential therapeutic target for liver diseases.
Liu R, Wu K, Li Y, Sun R, Li X. Liu R, et al. Pharmacol Res. 2020 May;155:104684. doi: 10.1016/j.phrs.2020.104684. Epub 2020 Feb 8. Pharmacol Res. 2020. PMID: 32045667 Review.
Human antigen R (HuR), also known as HuA and embryonic lethal abnormal vision-like 1 (ELAVL1), is a ubiquitously expressed RNA binding protein and functions as an RNA regulator and mediates the expression of va
Human antigen R (HuR), also known as HuA and embryonic lethal abnormal vision-lik
mRNA Post-Transcriptional Regulation by AU-Rich Element-Binding Proteins in Liver Inflammation and Cancer.
Dolicka D, Sobolewski C, Correia de Sousa M, Gjorgjieva M, Foti M. Dolicka D, et al. Int J Mol Sci. 2020 Sep 11;21(18):6648. doi: 10.3390/ijms21186648. Int J Mol Sci. 2020. PMID: 32932781 Free PMC article. Review.
While AUBPs have been shown to be involved in inflammatory processes and the development of various cancers, their important role and function in the development of chronic metabolic and inflammatory fatty liver diseases (FLDs), as well as in the progression of these disor …
While AUBPs have been shown to be involved in inflammatory processes and the development of various cancers, their important role and functi …
NEDDylation in liver cancer: The regulation of the RNA binding protein Hu antigen R.
Fernández-Ramos D, Martínez-Chantar ML. Fernández-Ramos D, et al. Pancreatology. 2015 Jul;15(4 Suppl):S49-54. doi: 10.1016/j.pan.2015.03.006. Epub 2015 Mar 20. Pancreatology. 2015. PMID: 25841271 Review.
A ground-breaking knowledge on a new critical aspect of HCC research has been to identify that NEDDylation plays a role in HCC by regulating the liver oncogenic driver Hu antigen R (HuR). HuR is a RNA-binding protein that stabilizes target mRNAs …
A ground-breaking knowledge on a new critical aspect of HCC research has been to identify that NEDDylation plays a role in HCC by regulating …
Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells.
Yang H, Zheng Y, Li TW, Peng H, Fernandez-Ramos D, Martínez-Chantar ML, Rojas AL, Mato JM, Lu SC. Yang H, et al. J Biol Chem. 2013 Aug 9;288(32):23161-70. doi: 10.1074/jbc.M113.487157. Epub 2013 Jun 28. J Biol Chem. 2013. PMID: 23814050 Free PMC article.
Resveratrol is growth-suppressive and pro-apoptotic in liver cancer cells. Methionine adenosyltransferase 2B (MAT2B) encodes for two dominant variants V1 and V2 that positively regulate growth, and V1 is anti-apoptotic when overexpressed. ...MATbeta interacts with …
Resveratrol is growth-suppressive and pro-apoptotic in liver cancer cells. Methionine adenosyltransferase 2B (MAT2B) encodes f …
AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway.
Chen T, Dai X, Dai J, Ding C, Zhang Z, Lin Z, Hu J, Lu M, Wang Z, Qi Y, Zhang L, Pan R, Zhao Z, Lu L, Liao W, Lu X. Chen T, et al. Cell Death Dis. 2020 Oct 2;11(10):822. doi: 10.1038/s41419-020-03030-7. Cell Death Dis. 2020. PMID: 33009373 Free PMC article.
In this study, we demostrated that depleting AFP significantly suppressed diethylnitrosamine (DEN)-induced liver tumor progression in an AFP gene-deficient mouse model. Similarly, knocking down AFP expression inhibited human HCC cell proliferation and tumor growth b …
In this study, we demostrated that depleting AFP significantly suppressed diethylnitrosamine (DEN)-induced liver tumor progression in …
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