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Year Number of Results
1997 1
1999 1
2005 1
2006 2
2007 1
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2015 5
2016 5
2018 1
2019 4
2020 3
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22 results
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Filters applied: . Clear all Unknown field was ignored: [Title/Abstrac]
Page 1
Autophagic HuR mRNA degradation induces survivin and MCL1 downregulation in YM155-treated human leukemia cells.
Chiou JT, Lee YC, Huang CH, Shi YJ, Wang LJ, Chang LS. Chiou JT, et al. Toxicol Appl Pharmacol. 2020 Jan 15;387:114857. doi: 10.1016/j.taap.2019.114857. Epub 2019 Dec 16. Toxicol Appl Pharmacol. 2020. PMID: 31837377
The aim of this study was to investigate the mechanism of YM155 cytotoxicity in human chronic myeloid leukemia (CML) cells. YM155-induced apoptosis of human CML K562 cells was characterized by ROS-mediated p38 MAPK activation, mitochondrial depolarization, an …
The aim of this study was to investigate the mechanism of YM155 cytotoxicity in human chronic myeloid leukemia (CML) cells. YM …
Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.
Lee SH, Mayr C. Lee SH, et al. Mol Cell. 2019 May 16;74(4):701-712.e9. doi: 10.1016/j.molcel.2019.03.006. Epub 2019 Apr 1. Mol Cell. 2019. PMID: 30948266 Free PMC article.
We investigated the function of the long BIRC3 3' UTR, which is upregulated in leukemia. The 3' UTR does not regulate BIRC3 protein localization or abundance but is required for CXCR4-mediated B cell migration. ...We further identified RNA-binding proteins differentially b …
We investigated the function of the long BIRC3 3' UTR, which is upregulated in leukemia. The 3' UTR does not regulate BIRC3 protein l …
Phosphorylation of ELAVL1 (Ser219/Ser316) mediated by PKC is required for erythropoiesis.
Zhou X, Wang S, Zheng M, Kuver A, Wan X, Dai K, Li X. Zhou X, et al. Biochim Biophys Acta Mol Cell Res. 2019 Feb;1866(2):214-224. doi: 10.1016/j.bbamcr.2018.10.021. Epub 2018 Nov 2. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30395882 Free article.
Elavl1 (also known as HuR), an RNA binding protein highly conserved between zebrafish and human, regulates gene expression by stabilizing target mRNA. ...Knockdown of elavl1a resulted in the hindrance of erythropoiesis and Hemin-induced erythroid differentiat
Elavl1 (also known as HuR), an RNA binding protein highly conserved between zebrafish and human, regulates gene express
MicroRNA-519 enhances HL60 human acute myeloid leukemia cell line proliferation by reducing the expression level of RNA-binding protein human antigen R.
Huang K, Dong B, Wang Y, Tian T, Zhang B. Huang K, et al. Mol Med Rep. 2015 Dec;12(6):7830-6. doi: 10.3892/mmr.2015.4455. Epub 2015 Oct 20. Mol Med Rep. 2015. PMID: 26499919 Free PMC article.
However, the role of miR-519 in acute myeloid leukemia (AML) has yet to be elucidated. The present study identified the effects of miR‑519 on HL60 human acute myeloid leukemia cell growth and apoptosis. ...In addition, the effects of human antigen
However, the role of miR-519 in acute myeloid leukemia (AML) has yet to be elucidated. The present study identified the effects of mi …
Identification of a miR-146b-Fas ligand axis in the development of neutropenia in T large granular lymphocyte leukemia.
Mariotti B, Calabretto G, Rossato M, Teramo A, Castellucci M, Barilà G, Leoncin M, Vicenzetto C, Facco M, Semenzato G, Bazzoni F, Zambello R. Mariotti B, et al. Haematologica. 2020 May;105(5):1351-1360. doi: 10.3324/haematol.2019.225060. Epub 2019 Aug 29. Haematologica. 2020. PMID: 31467122 Free PMC article.
Tlarge granular lymphocyte leukemia (T-LGLL) is characterized by the expansion of several large granular lymphocyte clones, among which a subset of large granular lymphocytes showing constitutively activated STAT3, a specific CD8(+)/CD4(-) phenotype and the presence of neu …
Tlarge granular lymphocyte leukemia (T-LGLL) is characterized by the expansion of several large granular lymphocyte clones, among whi …
IL-18-induced interaction between IMP3 and HuR contributes to COX-2 mRNA stabilization in acute myeloid leukemia.
Ko CY, Wang WL, Li CF, Jeng YM, Chu YY, Wang HY, Tseng JT, Wang JM. Ko CY, et al. J Leukoc Biol. 2016 Jan;99(1):131-41. doi: 10.1189/jlb.2A0414-228RR. Epub 2015 Sep 4. J Leukoc Biol. 2016. PMID: 26342105
Two RNA-binding proteins, human antigen R and insulin-like growth factor mRNA-binding protein 3, mediated the stabilization of COX-2 mRNA. ...We demonstrated further that JNK and/or ERK1/2 regulated human antigen R nucleocytoplasmi …
Two RNA-binding proteins, human antigen R and insulin-like growth factor mRNA-binding protein 3, mediated the st …
Regulation of Bcl-2 expression by HuR in HL60 leukemia cells and A431 carcinoma cells.
Ishimaru D, Ramalingam S, Sengupta TK, Bandyopadhyay S, Dellis S, Tholanikunnel BG, Fernandes DJ, Spicer EK. Ishimaru D, et al. Mol Cancer Res. 2009 Aug;7(8):1354-66. doi: 10.1158/1541-7786.MCR-08-0476. Epub 2009 Aug 11. Mol Cancer Res. 2009. PMID: 19671677 Free article.
Overexpression of the proto-oncogene bcl-2 promotes abnormal cell survival by inhibiting apoptosis. Expression of bcl-2 is determined, in part, by regulatory mechanisms that control the stability of bcl-2 mRNA. ...Knockdown of HuR in A431 cells leads to down-regulat …
Overexpression of the proto-oncogene bcl-2 promotes abnormal cell survival by inhibiting apoptosis. Expression of bcl-2 is determined …
Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation.
Podszywalow-Bartnicka P, Wolczyk M, Kusio-Kobialka M, Wolanin K, Skowronek K, Nieborowska-Skorska M, Dasgupta Y, Skorski T, Piwocka K. Podszywalow-Bartnicka P, et al. Cell Cycle. 2014;13(23):3727-41. doi: 10.4161/15384101.2014.965013. Cell Cycle. 2014. PMID: 25483082
We investigated 2 mRNA-binding proteins - HuR and TIAR showing specificity to AU-Rich Element (ARE) sites in 3'UTR of mRNA. BCR-ABL1 promoted cytosolic localization of TIAR and HuR, their binding to BRCA1 mRNA and formation of the TIAR-HuR complex. ...Altoget …
We investigated 2 mRNA-binding proteins - HuR and TIAR showing specificity to AU-Rich Element (ARE) sites in 3'UTR of mRNA. BCR-ABL1 …
mRNA export and cancer.
Siddiqui N, Borden KL. Siddiqui N, et al. Wiley Interdiscip Rev RNA. 2012 Jan-Feb;3(1):13-25. doi: 10.1002/wrna.101. Epub 2011 Jul 27. Wiley Interdiscip Rev RNA. 2012. PMID: 21796793 Review.
Studies on primary tumor specimens indicate that many common and specialized mRNA export factors are dysregulated in cancer including CRM1, eukaryotic translation initiation factor 4E (eIF4E), HuR, nucleoporin 88, REF/Aly, and THO. ...Recently, specific targeting of the eI …
Studies on primary tumor specimens indicate that many common and specialized mRNA export factors are dysregulated in cancer including CRM1, …
The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells.
Blanco FF, Jimbo M, Wulfkuhle J, Gallagher I, Deng J, Enyenihi L, Meisner-Kober N, Londin E, Rigoutsos I, Sawicki JA, Risbud MV, Witkiewicz AK, McCue PA, Jiang W, Rui H, Yeo CJ, Petricoin E, Winter JM, Brody JR. Blanco FF, et al. Oncogene. 2016 May;35(19):2529-41. doi: 10.1038/onc.2015.325. Epub 2015 Sep 21. Oncogene. 2016. PMID: 26387536 Free PMC article.
The hypoxia-inducible, pro-oncogenic, serine-threonine kinase PIM1 (Proviral Integration site for Moloney murine leukemia virus 1) has emerged as a key regulator of hypoxia-induced chemoresistance in PDA and other cancers. ...Here, we demonstrate that cis-acting AU-rich el …
The hypoxia-inducible, pro-oncogenic, serine-threonine kinase PIM1 (Proviral Integration site for Moloney murine leukemia virus 1) ha …
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