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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1800 1
1801 2
1912 1
1914 1
1917 1
1924 1
1926 2
1929 1
1933 2
1938 1
1940 1
1946 1
1947 2
1948 1
1949 3
1950 7
1951 6
1952 2
1953 5
1954 7
1955 12
1956 8
1957 2
1958 10
1959 10
1960 7
1961 4
1962 9
1963 3
1964 15
1965 10
1966 17
1967 25
1968 33
1969 32
1970 57
1971 80
1972 125
1973 176
1974 153
1975 230
1976 286
1977 315
1978 345
1979 465
1980 591
1981 655
1982 882
1983 974
1984 915
1985 867
1986 931
1987 860
1988 797
1989 821
1990 852
1991 759
1992 784
1993 818
1994 825
1995 818
1996 824
1997 863
1998 869
1999 844
2000 929
2001 923
2002 890
2003 942
2004 935
2005 1083
2006 1158
2007 1073
2008 1176
2009 1159
2010 1214
2011 1259
2012 1299
2013 1434
2014 1462
2015 1503
2016 1433
2017 1532
2018 1690
2019 1923
2020 2118
2021 848
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Search Results

43,583 results
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Page 1
The United States opioid epidemic.
Lyden J, Binswanger IA. Lyden J, et al. Semin Perinatol. 2019 Apr;43(3):123-131. doi: 10.1053/j.semperi.2019.01.001. Epub 2019 Jan 14. Semin Perinatol. 2019. PMID: 30711195 Free PMC article. Review.
The United States opioid epidemic is a nationwide public health crisis. Initially driven by increased consumption and availability of pharmaceutical opioids, an increasing number of opioid overdoses are now related to heroin and illicitly manufactured fentany …
The United States opioid epidemic is a nationwide public health crisis. Initially driven by increased consumption and availability of …
Opioid receptors.
Waldhoer M, Bartlett SE, Whistler JL. Waldhoer M, et al. Annu Rev Biochem. 2004;73:953-90. doi: 10.1146/annurev.biochem.73.011303.073940. Annu Rev Biochem. 2004. PMID: 15189164 Review.
They are activated both by endogenously produced opioid peptides and by exogenously administered opiate compounds, some of which are not only among the most effective analgesics known but also highly addictive drugs of abuse. A fundamental question in addiction biol …
They are activated both by endogenously produced opioid peptides and by exogenously administered opiate compounds, some of whi …
Opioid Use Disorders.
Sharma B, Bruner A, Barnett G, Fishman M. Sharma B, et al. Child Adolesc Psychiatr Clin N Am. 2016 Jul;25(3):473-87. doi: 10.1016/j.chc.2016.03.002. Epub 2016 Apr 9. Child Adolesc Psychiatr Clin N Am. 2016. PMID: 27338968 Free PMC article. Review.
Opioid use and addiction in adolescents and young adults is a health problem of epidemic proportions, with devastating consequences for youth and their families. Opioid overdose is a life-threatening emergency that should be treated with naloxone, and respiratory su …
Opioid use and addiction in adolescents and young adults is a health problem of epidemic proportions, with devastating consequences f …
Respiratory depression and brain hypoxia induced by opioid drugs: Morphine, oxycodone, heroin, and fentanyl.
Kiyatkin EA. Kiyatkin EA. Neuropharmacology. 2019 Jun;151:219-226. doi: 10.1016/j.neuropharm.2019.02.008. Epub 2019 Feb 5. Neuropharmacology. 2019. PMID: 30735692 Free PMC article. Review.
Opioid drugs are important tools to alleviate pain of different origins, but they have strong addictive potential and their abuse at higher doses often results in serious health complications. ...The goal of this review paper is to consider changes in brain oxygen levels i …
Opioid drugs are important tools to alleviate pain of different origins, but they have strong addictive potential and their abuse at …
Maintenance medication for opiate addiction: the foundation of recovery.
Bart G. Bart G. J Addict Dis. 2012;31(3):207-25. doi: 10.1080/10550887.2012.694598. J Addict Dis. 2012. PMID: 22873183 Free PMC article. Review.
This article provides a topical review of the three medications approved by the Food and Drug Administration for long-term treatment of opiate dependence: the opioid-agonist methadone, the partial opioid-agonist buprenorphine, and the opioid-antagonist …
This article provides a topical review of the three medications approved by the Food and Drug Administration for long-term treatment of o …
Fentanyl depression of respiration: Comparison with heroin and morphine.
Hill R, Santhakumar R, Dewey W, Kelly E, Henderson G. Hill R, et al. Br J Pharmacol. 2020 Jan;177(2):254-266. doi: 10.1111/bph.14860. Epub 2019 Dec 23. Br J Pharmacol. 2020. PMID: 31499594 Free PMC article.
BACKGROUND AND PURPOSE: Fentanyl overdose deaths have reached "epidemic" levels in North America. Death in opioid overdose invariably results from respiratory depression. In the present work, we have characterized how fentanyl depresses respiration, and by comparing fentan …
BACKGROUND AND PURPOSE: Fentanyl overdose deaths have reached "epidemic" levels in North America. Death in opioid overdose invariably …
Characteristics and circumstances of heroin and pharmaceutical opioid overdose deaths: Comparison across opioids.
Roxburgh A, Hall WD, Gisev N, Degenhardt L. Roxburgh A, et al. Drug Alcohol Depend. 2019 Dec 1;205:107533. doi: 10.1016/j.drugalcdep.2019.06.035. Epub 2019 Oct 22. Drug Alcohol Depend. 2019. PMID: 31704378
BACKGROUND: Although much is known about the correlates of heroin overdose, less is known about pharmaceutical opioid (PO) overdose. ...The NCIS is an online database of deaths reportable to the coroner, and contains coroner's findings, autopsy and toxicology report …
BACKGROUND: Although much is known about the correlates of heroin overdose, less is known about pharmaceutical opioid (PO) ove …
Naloxone for heroin, prescription opioid, and illicitly made fentanyl overdoses: Challenges and innovations responding to a dynamic epidemic.
Fairbairn N, Coffin PO, Walley AY. Fairbairn N, et al. Int J Drug Policy. 2017 Aug;46:172-179. doi: 10.1016/j.drugpo.2017.06.005. Epub 2017 Jul 4. Int J Drug Policy. 2017. PMID: 28687187 Free PMC article.
We review the evolution of naloxone programming through the heroin overdose era of the 1990's, the prescription opioid era of the 2000's, and the current overdose crisis stemming from the synthetic opioid era of illicitly manufactured fentanyl and its analogu …
We review the evolution of naloxone programming through the heroin overdose era of the 1990's, the prescription opioid era of …
Correlates of Long-Term Opioid Abstinence After Randomization to Methadone Versus Buprenorphine/Naloxone in a Multi-Site Trial.
Zhu Y, Evans EA, Mooney LJ, Saxon AJ, Kelleghan A, Yoo C, Hser YI. Zhu Y, et al. J Neuroimmune Pharmacol. 2018 Dec;13(4):488-497. doi: 10.1007/s11481-018-9801-x. Epub 2018 Aug 9. J Neuroimmune Pharmacol. 2018. PMID: 30094695 Free PMC article. Clinical Trial.
Previous studies have reported that 5-year opioid abstinence is a good predictor of reduced likelihoods of relapse, but factors that shape long-term opioid abstinence are poorly understood. ...During the 5 years prior to the participants' last follow-up interview, 2 …
Previous studies have reported that 5-year opioid abstinence is a good predictor of reduced likelihoods of relapse, but factors that …
Opioid Overdose Prevention Programs Providing Naloxone to Laypersons - United States, 2014.
Wheeler E, Jones TS, Gilbert MK, Davidson PJ; Centers for Disease Control and Prevention (CDC). Wheeler E, et al. MMWR Morb Mortal Wkly Rep. 2015 Jun 19;64(23):631-5. MMWR Morb Mortal Wkly Rep. 2015. PMID: 26086633 Free PMC article.
Among these, 16,235 (37%) were associated with prescription opioid analgesics (e.g., oxycodone and hydrocodone) and 8,257 (19%) with heroin. ...Since 1996, an increasing number of programs provide laypersons with training and kits containing the opioid antago …
Among these, 16,235 (37%) were associated with prescription opioid analgesics (e.g., oxycodone and hydrocodone) and 8,257 (19%) with …
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