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Year Number of Results
1933 1
1945 41
1946 27
1947 32
1948 23
1949 10
1950 104
1951 143
1952 90
1953 117
1954 43
1955 59
1956 72
1957 66
1958 46
1959 31
1960 42
1961 46
1962 40
1963 94
1964 79
1965 92
1966 113
1967 60
1968 77
1969 83
1970 79
1971 84
1972 75
1973 65
1974 82
1975 101
1976 95
1977 90
1978 125
1979 101
1980 125
1981 145
1982 135
1983 157
1984 210
1985 212
1986 226
1987 226
1988 229
1989 226
1990 232
1991 277
1992 326
1993 285
1994 368
1995 461
1996 545
1997 511
1998 629
1999 720
2000 788
2001 767
2002 857
2003 1018
2004 1075
2005 1108
2006 1268
2007 1342
2008 1427
2009 1454
2010 1612
2011 1758
2012 1882
2013 2113
2014 2123
2015 2257
2016 2341
2017 2430
2018 2613
2019 2683
2020 2925
2021 3128
2022 3036
2023 2960
2024 2997
2025 431

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51,254 results

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Page 1
The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress.
Raghu G, Berk M, Campochiaro PA, Jaeschke H, Marenzi G, Richeldi L, Wen FQ, Nicoletti F, Calverley PMA. Raghu G, et al. Curr Neuropharmacol. 2021;19(8):1202-1224. doi: 10.2174/1570159X19666201230144109. Curr Neuropharmacol. 2021. PMID: 33380301 Free PMC article. Review.
The sulfhydryl-containing tripeptide glutathione (GSH), which is synthesized and maintained at high concentrations in all cells, is one of the mechanisms by which cells protect themselves from oxidative stress. N-acetylcysteine (NAC), a synthetic derivative o …
The sulfhydryl-containing tripeptide glutathione (GSH), which is synthesized and maintained at high concentrations in all cells, is one of t …
The mechanism of action of N-acetylcysteine (NAC): The emerging role of H(2)S and sulfane sulfur species.
Pedre B, Barayeu U, Ezeriņa D, Dick TP. Pedre B, et al. Pharmacol Ther. 2021 Dec;228:107916. doi: 10.1016/j.pharmthera.2021.107916. Epub 2021 Jun 23. Pharmacol Ther. 2021. PMID: 34171332 Free article. Review.
Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine (NAC) is the standard of care to treat paracetamol intoxication, and is included on the World Health Organization's list of essential medicines. ...In this review, we d …
Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine (NAC) is the standard of car …
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review.
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R. Deepmala, et al. Neurosci Biobehav Rev. 2015 Aug;55:294-321. doi: 10.1016/j.neubiorev.2015.04.015. Epub 2015 May 6. Neurosci Biobehav Rev. 2015. PMID: 25957927 Free article. Review.
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. ...Overall, NAC treatment appears to be safe and tolerable. Further well designed, larger controlled trials are needed for specific psychiatric and neurolog
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. ...Overall, NAC
Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases.
Tardiolo G, Bramanti P, Mazzon E. Tardiolo G, et al. Molecules. 2018 Dec 13;23(12):3305. doi: 10.3390/molecules23123305. Molecules. 2018. PMID: 30551603 Free PMC article. Review.
N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific interest for decades due to its important medical applications. It also represents a nutritional supplement in the human diet. NAC is a glutathione precursor and s
N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific interest for decades due to it
N-acetylcysteine as a new prominent approach for treating psychiatric disorders.
Smaga I, Frankowska M, Filip M. Smaga I, et al. Br J Pharmacol. 2021 Jul;178(13):2569-2594. doi: 10.1111/bph.15456. Epub 2021 May 5. Br J Pharmacol. 2021. PMID: 33760228 Free article. Review.
N-acetylcysteine (NAC) is a well-known and safe mucolytic agent, also used in patients with paracetamol overdose. ...Although preclinical studies have shown a positive effect of NAC on animal models of psychiatric disorders, the clinical efficacy of
N-acetylcysteine (NAC) is a well-known and safe mucolytic agent, also used in patients with paracetamol overdose. ...Al
Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury.
Jaeschke H, Ramachandran A. Jaeschke H, et al. Annu Rev Pathol. 2024 Jan 24;19:453-478. doi: 10.1146/annurev-pathmechdis-051122-094016. Annu Rev Pathol. 2024. PMID: 38265880 Free PMC article. Review.
Understanding these mechanisms of cell death led to discovery of N-acetylcysteine and recently fomepizole as effective antidotes against APAP toxicity....
Understanding these mechanisms of cell death led to discovery of N-acetylcysteine and recently fomepizole as effective antidot …
Pharmacokinetics of N-acetyl-l-cysteine in chickens.
Roydeva A, Beleva G, Gadzhakov D, Milanova A. Roydeva A, et al. J Vet Pharmacol Ther. 2024 Sep;47(5):403-415. doi: 10.1111/jvp.13452. Epub 2024 May 15. J Vet Pharmacol Ther. 2024. PMID: 38751162
N-acetyl-l-cysteine (NAC) has been suggested as an antioxidant that can alleviate the negative effects of stress conditions in broilers. ...Therefore, the study aimed to shed more light on the PK properties of NAC in chickens. Broilers we
N-acetyl-l-cysteine (NAC) has been suggested as an antioxidant that can alleviate the negative effects of
N-acetyl-L-cysteine ameliorates gestational diabetes mellitus by inhibiting oxidative stress.
Wang P, Ma H, Hou X, Song L, Feng M. Wang P, et al. Biotechnol Appl Biochem. 2023 Jun;70(3):1128-1136. doi: 10.1002/bab.2426. Epub 2022 Dec 27. Biotechnol Appl Biochem. 2023. PMID: 36517965
Gestational diabetes mellitus (GDM) is a common pregnant disorder that needs careful medical attention. N-acetyl-L-cysteine (NAC) is a well-recognized antioxidant to treat oxidative stress-induced diseases. ...Therefore, NAC might serve a …
Gestational diabetes mellitus (GDM) is a common pregnant disorder that needs careful medical attention. N-acetyl-L-c
Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits.
Rushworth GF, Megson IL. Rushworth GF, et al. Pharmacol Ther. 2014 Feb;141(2):150-9. doi: 10.1016/j.pharmthera.2013.09.006. Epub 2013 Sep 28. Pharmacol Ther. 2014. PMID: 24080471 Review.
N-acetyl-l-cysteine (NAC) has long been used therapeutically for the treatment of acetaminophen (paracetamol) overdose, acting as a precursor for the substrate (l-cysteine) in synthesis of hepatic glutathione (GSH) depleted through drug conjugat
N-acetyl-l-cysteine (NAC) has long been used therapeutically for the treatment of acetaminophen (paraceta
N-acetylcysteine.
Moldéus P, Cotgreave IA. Moldéus P, et al. Methods Enzymol. 1994;234:482-92. doi: 10.1016/0076-6879(94)34119-2. Methods Enzymol. 1994. PMID: 7808322 Review. No abstract available.
51,254 results
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