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The DnaA inhibitor SirA acts in the same pathway as Soj (ParA) to facilitate oriC segregation during Bacillus subtilis sporulation.
Duan Y, Huey JD, Herman JK. Duan Y, et al. Among authors: herman jk. Mol Microbiol. 2016 Nov;102(3):530-544. doi: 10.1111/mmi.13477. Epub 2016 Aug 25. Mol Microbiol. 2016. PMID: 27489185 Free article.
By analyzing loss-of-function variants of both SirA and DnaA, we observe that SirA's ability to inhibit DNA replication can be genetically separated from its role in oriC capture. ...One such variant, SirA(P141T) , remained functional in regard to inhibiting …
By analyzing loss-of-function variants of both SirA and DnaA, we observe that SirA's ability to inhibit DNA replication can be …
SirA enforces diploidy by inhibiting the replication initiator DnaA during spore formation in Bacillus subtilis.
Wagner JK, Marquis KA, Rudner DZ. Wagner JK, et al. Mol Microbiol. 2009 Sep;73(5):963-74. doi: 10.1111/j.1365-2958.2009.06825.x. Epub 2009 Aug 4. Mol Microbiol. 2009. PMID: 19682252 Free PMC article.
We show that SirA interacts with DnaA and displaces it from the replication origin. ...Finally, cells lacking SirA over-replicate during sporulation. These results support a model in which induction of SirA enforces diploidy by inhibiting replication initiati …
We show that SirA interacts with DnaA and displaces it from the replication origin. ...Finally, cells lacking SirA over-replic …