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The DnaA inhibitor SirA acts in the same pathway as Soj (ParA) to facilitate oriC segregation during Bacillus subtilis sporulation.
Duan Y, Huey JD, Herman JK. Duan Y, et al. Among authors: herman jk. Mol Microbiol. 2016 Nov;102(3):530-544. doi: 10.1111/mmi.13477. Epub 2016 Aug 25. Mol Microbiol. 2016. PMID: 27489185 Free article.
During Bacillus subtilis sporulation, chromosome copy number is reduced to two, and cells divide asymmetrically to produce the future spore (forespore) compartment. ...By analyzing loss-of-function variants of both SirA and DnaA, we observe that SirA's abilit …
During Bacillus subtilis sporulation, chromosome copy number is reduced to two, and cells divide asymmetrically to produce the future …
SirA enforces diploidy by inhibiting the replication initiator DnaA during spore formation in Bacillus subtilis.
Wagner JK, Marquis KA, Rudner DZ. Wagner JK, et al. Mol Microbiol. 2009 Sep;73(5):963-74. doi: 10.1111/j.1365-2958.2009.06825.x. Epub 2009 Aug 4. Mol Microbiol. 2009. PMID: 19682252 Free PMC article.
Here, we investigate the mechanism by which the bacterium Bacillus subtilis enforces diploidy as it differentiates into a dormant spore. ...We show that SirA interacts with DnaA and displaces it from the replication origin. As a result, expression of SirA dur …
Here, we investigate the mechanism by which the bacterium Bacillus subtilis enforces diploidy as it differentiates into a dormant spo …
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