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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1993 1
1995 1
1996 1
1997 3
1999 1
2000 3
2001 1
2002 3
2003 1
2004 8
2005 2
2006 2
2007 2
2008 5
2009 6
2010 5
2011 4
2012 7
2013 5
2014 17
2015 18
2016 30
2017 20
2018 31
2019 40
2020 41
2021 38
2022 36
2023 35
2024 32
2025 26

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391 results

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Page 1
Identification of pyrazole scaffold inhibitors targeting cyclin-dependent kinase 8 for potential use in pulmonary fibrosis.
Lin TE, Hsu KC, Chou CH, Tsai EY, Wu YW, Sung TY, Hsu JY, Hsieh JH, Yen SC, Chang YW, Pan SL, Huang WJ, Yang CR. Lin TE, et al. Among authors: hsieh jh. Biochem Pharmacol. 2025 Jul;237:116959. doi: 10.1016/j.bcp.2025.116959. Epub 2025 Apr 23. Biochem Pharmacol. 2025. PMID: 40280247 Free article.
Herein, a structure-based virtual screening (SBVS) campaign led to the identification of three CDK8 inhibitors. Testing of candidate inhibitors in protein and cellular assays confirmed CDK8 inhibition, with the most potent inhibitor producing an IC(50) value of 398.8 nM. . …
Herein, a structure-based virtual screening (SBVS) campaign led to the identification of three CDK8 inhibitors. Testing of candidate inhibit …
Machine Learning for Toxicity Prediction Using Chemical Structures: Pillars for Success in the Real World.
Seal S, Mahale M, García-Ortegón M, Joshi CK, Hosseini-Gerami L, Beatson A, Greenig M, Shekhar M, Patra A, Weis C, Mehrjou A, Badré A, Paisley B, Lowe R, Singh S, Shah F, Johannesson B, Williams D, Rouquie D, Clevert DA, Schwab P, Richmond N, Nicolaou CA, Gonzalez RJ, Naven R, Schramm C, Vidler LR, Mansouri K, Walters WP, Wilk DD, Spjuth O, Carpenter AE, Bender A. Seal S, et al. Among authors: mansouri k. Chem Res Toxicol. 2025 May 19;38(5):759-807. doi: 10.1021/acs.chemrestox.5c00033. Epub 2025 May 2. Chem Res Toxicol. 2025. PMID: 40314361 Free PMC article. Review.
However, toxicity-related end points have always been challenging to evaluate experimentally with respect to in vivo translation due to the required resources for human and animal studies; this has impacted data availability in the field. ...We focus on five crucial pillar …
However, toxicity-related end points have always been challenging to evaluate experimentally with respect to in vivo translation due …
Quantitative and qualitative concordance between clinical and nonclinical toxicity data.
Weitekamp CA, Paul Friedman K, Harrill AH, Auerbach S, Bandele O, Barton-Maclaren TS, Fitzpatrick S, Mezencev R, Santillo M, Simanainen U, Smith D, Whelan M, Thomas RS. Weitekamp CA, et al. Among authors: auerbach s. Toxicol Sci. 2025 May 16:kfaf071. doi: 10.1093/toxsci/kfaf071. Online ahead of print. Toxicol Sci. 2025. PMID: 40378198
391 results