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HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection.
Rica R, Waldherr M, Miyakoda E, Kutschat AP, Schülein M, Zhang J, Orbegozo-Medina RA, Sandner L, Stolz V, Waltenberger D, Krausgruber T, Bock C, Boucheron N, Seruggia D, Ellmeier W, Sakaguchi S. Rica R, et al. Among authors: ellmeier w. J Exp Med. 2025 Aug 4;222(8):e20240829. doi: 10.1084/jem.20240829. Epub 2025 Jun 4. J Exp Med. 2025. PMID: 40464916 Free PMC article.
We uncovered that HDAC1 controls the generation and maintenance of effector-like CX3CR1+ Tex cells in a CD8+ T cell-intrinsic manner. ...Our study uncovers a selective role for HDAC1 in CX3CR1+ Tex subset differentiation, which is essential for controlling viral loa …
We uncovered that HDAC1 controls the generation and maintenance of effector-like CX3CR1+ Tex cells in a CD8+ T cell-intrinsic manner. …
HDAC1 acts as a tumor suppressor in ALK-positive anaplastic large cell lymphoma: implications for HDAC inhibitor therapy.
Zrimšek M, Draganić K, Malzer A, Doblmayr V, Mišura K, de Freitas E Silva R, Matthews JD, Iannelli F, Wohlhaupter S, Pérez Malla CU, Fischer H, Schachner H, Schiefer AI, Sheibani-Tezerji R, Chiarle R, Turner SD, Ellmeier W, Seiser C, Egger G. Zrimšek M, et al. Among authors: ellmeier w. Leukemia. 2025 Jun;39(6):1412-1424. doi: 10.1038/s41375-025-02584-9. Epub 2025 Apr 2. Leukemia. 2025. PMID: 40175628 Free PMC article.
To further disentangle the effects of systemic HDAC inhibition from thymocyte intrinsic effects, conditional genetic deletions of HDAC1 and HDAC2 enzymes were employed. In sharp contrast, T cell-specific deletion of Hdac1 or Hdac2 in the ALCL mouse model sign …
To further disentangle the effects of systemic HDAC inhibition from thymocyte intrinsic effects, conditional genetic deletions of …
Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma.
Khan M, Alteneder M, Reiter W, Krausgruber T, Dobnikar L, Madern M, Waldherr M, Bock C, Hartl M, Ellmeier W, Henriksson J, Boucheron N. Khan M, et al. Among authors: ellmeier w. Nat Commun. 2025 Mar 15;16(1):2565. doi: 10.1038/s41467-025-57590-3. Nat Commun. 2025. PMID: 40089475 Free PMC article.
Here we investigate immune regulation in allergic asthma by single-cell RNA sequencing in mice challenged with house dust mite, in the presence and absence of histone deacetylase 1 (HDAC1) function. Our analyses indicate two distinct highly proinflammatory subsets of lung …
Here we investigate immune regulation in allergic asthma by single-cell RNA sequencing in mice challenged with house dust mite, in the prese …
HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections.
Penninger P, Brezovec H, Tsymala I, Teufl M, Phan-Canh T, Bitencourt T, Brinkmann M, Glaser W, Ellmeier W, Bonelli M, Kuchler K. Penninger P, et al. Among authors: ellmeier w. Cell Rep. 2024 Dec 24;43(12):114993. doi: 10.1016/j.celrep.2024.114993. Epub 2024 Nov 23. Cell Rep. 2024. PMID: 39580799 Free article.
Histone deacetylases (HDACs) contribute to shaping many aspects of T cell lineage functions in anti-infective surveillance; however, their role in fungus-specific immune responses remains poorly understood. Using a T cell-specific deletion of HDAC1, we uncover its critical …
Histone deacetylases (HDACs) contribute to shaping many aspects of T cell lineage functions in anti-infective surveillance; however, their r …
The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity.
De Sá Fernandes C, Novoszel P, Gastaldi T, Krauß D, Lang M, Rica R, Kutschat AP, Holcmann M, Ellmeier W, Seruggia D, Strobl H, Sibilia M. De Sá Fernandes C, et al. Among authors: ellmeier w. Cell Rep. 2024 Jun 25;43(6):114308. doi: 10.1016/j.celrep.2024.114308. Epub 2024 Jun 2. Cell Rep. 2024. PMID: 38829740 Free article.
Here, we investigate the impact of histone deacetylation on DCs by genetically deleting histone deacetylase 1 (HDAC1) or HDAC2 in hematopoietic progenitors and CD11c-expressing cells. While HDAC2 is not critical for DC development, HDAC1 deletion impairs pro-pDC and …
Here, we investigate the impact of histone deacetylation on DCs by genetically deleting histone deacetylase 1 (HDAC1) or HDAC2 in hem …
Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases.
Hamminger P, Marchetti L, Preglej T, Platzer R, Zhu C, Kamnev A, Rica R, Stolz V, Sandner L, Alteneder M, Kaba E, Waltenberger D, Huppa JB, Trauner M, Bock C, Lyck R, Bauer J, Dupré L, Seiser C, Boucheron N, Engelhardt B, Ellmeier W. Hamminger P, et al. Among authors: ellmeier w. J Autoimmun. 2021 May;119:102610. doi: 10.1016/j.jaut.2021.102610. Epub 2021 Feb 20. J Autoimmun. 2021. PMID: 33621930 Free article.
In this study, we uncover a novel role for histone deacetylase 1 (HDAC1) in controlling effector CD4(+) T cell migration, thereby providing mechanistic insight into why a T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis (E …
In this study, we uncover a novel role for histone deacetylase 1 (HDAC1) in controlling effector CD4(+) T cell migration, thereby pro …
Histone deacetylases as targets in autoimmune and autoinflammatory diseases.
Hamminger P, Rica R, Ellmeier W. Hamminger P, et al. Among authors: ellmeier w. Adv Immunol. 2020;147:1-59. doi: 10.1016/bs.ai.2020.06.001. Epub 2020 Jul 15. Adv Immunol. 2020. PMID: 32981634
Moreover, many non-histone targets of HATs and HDACs are known, suggesting a crucial role for lysine acetylation as a posttranslational modification on the cellular proteome and protein function far beyond chromatin-mediated gene regulation. The HDAC family consists of 18 …
Moreover, many non-histone targets of HATs and HDACs are known, suggesting a crucial role for lysine acetylation as a posttranslational modi …
Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation.
Preglej T, Hamminger P, Luu M, Bulat T, Andersen L, Göschl L, Stolz V, Rica R, Sandner L, Waltenberger D, Tschismarov R, Faux T, Boenke T, Laiho A, Elo LL, Sakaguchi S, Steiner G, Decker T, Bohle B, Visekruna A, Bock C, Strobl B, Seiser C, Boucheron N, Ellmeier W. Preglej T, et al. Among authors: ellmeier w. JCI Insight. 2020 Feb 27;5(4):e133393. doi: 10.1172/jci.insight.133393. JCI Insight. 2020. PMID: 32102981 Free PMC article.
Finally, murine and human CD4+ T cells treated with short-chain fatty acids, which are commensal-produced metabolites acting as HDAC inhibitors, upregulated CTL genes. Our data demonstrate that HDAC1-HDAC2 restrain CD4+ CTL differentiation. Thus, HDAC1-HDAC2 …
Finally, murine and human CD4+ T cells treated with short-chain fatty acids, which are commensal-produced metabolites acting as HDAC …
Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis.
Göschl L, Preglej T, Boucheron N, Saferding V, Müller L, Platzer A, Hirahara K, Shih HY, Backlund J, Matthias P, Niederreiter B, Hladik A, Kugler M, Gualdoni GA, Scheinecker C, Knapp S, Seiser C, Holmdahl R, Tillmann K, Plasenzotti R, Podesser B, Aletaha D, Smolen JS, Karonitsch T, Steiner G, Ellmeier W, Bonelli M. Göschl L, et al. Among authors: ellmeier w. J Autoimmun. 2020 Mar;108:102379. doi: 10.1016/j.jaut.2019.102379. Epub 2019 Dec 26. J Autoimmun. 2020. PMID: 31883829
The inflammatory cytokines IL-17 and IL-6 were significantly decreased in sera of HDAC1-cKO mice. IL-6 treated HDAC1-deficient CD4(+) T cells showed an impaired upregulation of CCR6. ...Accordingly, analysis of human RNA-sequencing (RNA-seq) data and histological an …
The inflammatory cytokines IL-17 and IL-6 were significantly decreased in sera of HDAC1-cKO mice. IL-6 treated HDAC1-deficient …
Author Correction: Histone deacetylase function in CD4+ T cells.
Ellmeier W, Seiser C. Ellmeier W, et al. Nat Rev Immunol. 2019 Apr;19(4):266. doi: 10.1038/s41577-019-0153-4. Nat Rev Immunol. 2019. PMID: 30862885
In Table 1 in the originally published version of this article, the phenotype of Hdac1-cKO CD8+ T cells (3rd row) was incorrectly described. This has been corrected in the HTML and PDF versions of the manuscript....
In Table 1 in the originally published version of this article, the phenotype of Hdac1-cKO CD8+ T cells (3rd row) was incorrectly des …
17 results