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84 results

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Page 1
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S. Tawbi HA, et al. Lancet Oncol. 2017 Nov;18(11):1493-1501. doi: 10.1016/S1470-2045(17)30624-1. Epub 2017 Oct 4. Lancet Oncol. 2017. PMID: 28988646 Free PMC article. Clinical Trial.
Seven (18%) of 40 patients with soft-tissue sarcoma had an objective response, including four (40%) of ten patients with undifferentiated pleomorphic sarcoma, two (20%) of ten patients with liposarcoma, and one (10%) of ten patients with synovial sa …
Seven (18%) of 40 patients with soft-tissue sarcoma had an objective response, including four (40%) of ten patients with undiffere …
Safety and efficacy of pembrolizumab, radiation therapy, and surgery versus radiation therapy and surgery for stage III soft tissue sarcoma of the extremity (SU2C-SARC032): an open-label, randomised clinical trial.
Mowery YM, Ballman KV, Hong AM, Schuetze SM, Wagner AJ, Monga V, Heise RS, Attia S, Choy E, Burgess MA, Bae S, Pryor DI, Van Tine BA, Tinoco G, Chmielowski B, Freeman C, Gronchi A, Meyer CF, Dickson MA, Hartner L, Davis LE, Powers BC, Moding EJ, Weinhold KJ, van de Rijn M, Brigman BE, Riedel RF, Kirsch DG. Mowery YM, et al. Lancet. 2024 Nov 23;404(10467):2053-2064. doi: 10.1016/S0140-6736(24)01812-9. Epub 2024 Nov 12. Lancet. 2024. PMID: 39547252 Free PMC article. Clinical Trial.
METHODS: We completed an open-label, randomised clinical trial in patients with grade 2 or 3, stage III undifferentiated pleomorphic sarcoma or dedifferentiated or pleomorphic liposarcoma of the extremity and limb girdle. ...INTERPRETATION: Addition of …
METHODS: We completed an open-label, randomised clinical trial in patients with grade 2 or 3, stage III undifferentiated pleomorph …
Dedifferentiated liposarcoma.
Nascimento AG. Nascimento AG. Semin Diagn Pathol. 2001 Nov;18(4):263-6. Semin Diagn Pathol. 2001. PMID: 11757866 Review.
Dedifferentiated liposarcoma is a high-grade nonlipogenic sarcoma that arises in a background of a preexisting well-differentiated liposarcoma. The phenomenon of dedifferentiation is time dependent, and primary or de novo tumors exceed secondary neoplasms in a ratio of 9:1 …
Dedifferentiated liposarcoma is a high-grade nonlipogenic sarcoma that arises in a background of a preexisting well-differentiated li …
Increased incidence of malignant melanoma and other rare cutaneous cancers in the setting of chronic lymphocytic leukemia.
Brewer JD, Shanafelt TD, Call TG, Cerhan JR, Roenigk RK, Weaver AL, Otley CC. Brewer JD, et al. Int J Dermatol. 2015 Aug;54(8):e287-93. doi: 10.1111/ijd.12564. Epub 2015 Mar 13. Int J Dermatol. 2015. PMID: 25772131
Standardized incidence ratios (SIRs) for invasive malignant melanoma, Merkel cell carcinoma, malignant fibrous histiocytoma, dermatofibrosarcoma protuberans, Kaposi's sarcoma, and sebaceous carcinoma were 2.3, 8.2, 3.6, 2.5, 2.9, and 1.4, respec …
Standardized incidence ratios (SIRs) for invasive malignant melanoma, Merkel cell carcinoma, malignant fibrous histi …
Angiomatoid fibrous histiocytoma occurring at distal/acral extremity sites: clinicopathological and molecular study of 26 cases highlighting frequent myxoid histology and site-dependent genotypic variation.
Agaimy A, Molligan J, Alruwaii FI, Antonescu CR, Demicco EG, Dickson BC, Gross J, Michal M, Perry K, Tögel L, Stoehr R, Din NU, Folpe AL. Agaimy A, et al. Virchows Arch. 2025 Sep;487(3):587-595. doi: 10.1007/s00428-025-04199-y. Epub 2025 Aug 1. Virchows Arch. 2025. PMID: 40748380 Free PMC article.
Angiomatoid fibrous histiocytoma (AFH) is a rare mesenchymal neoplasm of borderline malignancy (locally recurring, rarely metastasizing), most often involving the limbs, trunk, and head/neck. ...
Angiomatoid fibrous histiocytoma (AFH) is a rare mesenchymal neoplasm of borderline malignancy (locally recurring, rarely meta …
Best practices in diagnostic immunohistochemistry: pleomorphic cutaneous spindle cell tumors.
Folpe AL, Cooper K. Folpe AL, et al. Arch Pathol Lab Med. 2007 Oct;131(10):1517-24. doi: 10.5858/2007-131-1517-BPIDIP. Arch Pathol Lab Med. 2007. PMID: 17922587 Free article. Review.
CONTEXT: Pleomorphic cutaneous spindle cell tumors can be difficult to distinguish solely on histologic grounds. ...
CONTEXT: Pleomorphic cutaneous spindle cell tumors can be difficult to distinguish solely on histologic grounds. ...
Correlative Analyses of the SARC028 Trial Reveal an Association Between Sarcoma-Associated Immune Infiltrate and Response to Pembrolizumab.
Keung EZ, Burgess M, Salazar R, Parra ER, Rodrigues-Canales J, Bolejack V, Van Tine BA, Schuetze SM, Attia S, Riedel RF, Hu J, Okuno SH, Priebat DA, Movva S, Davis LE, Reed DR, Reuben A, Roland CL, Reinke D, Lazar AJ, Wang WL, Wargo JA, Tawbi HA. Keung EZ, et al. Clin Cancer Res. 2020 Mar 15;26(6):1258-1266. doi: 10.1158/1078-0432.CCR-19-1824. Epub 2020 Jan 3. Clin Cancer Res. 2020. PMID: 31900276 Free PMC article. Clinical Trial.
PURPOSE: We recently reported a 17.5% objective RECIST 1.1 response rate in a phase II study of pembrolizumab in patients with advanced sarcoma (SARC028). The majority of responses occurred in undifferentiated pleomorphic sarcoma (UPS) and dedifferenti …
PURPOSE: We recently reported a 17.5% objective RECIST 1.1 response rate in a phase II study of pembrolizumab in patients with advanced s …
The impact of advances in molecular genetic pathology on the classification, diagnosis and treatment of selected soft tissue tumors of the head and neck.
García JJ, Folpe AL. García JJ, et al. Head Neck Pathol. 2010 Mar;4(1):70-6. doi: 10.1007/s12105-009-0160-z. Epub 2010 Jan 22. Head Neck Pathol. 2010. PMID: 20237992 Free PMC article. Review.
This reviews details some ways in which molecular techniques have strengthened conventional diagnostic and management approaches to low-grade fibromyxoid sarcoma, angiomatoid (malignant) fibrous histiocytoma, and dermatofibrosarcoma protuberans, all of …
This reviews details some ways in which molecular techniques have strengthened conventional diagnostic and management approaches to low-grad …
Pleomorphic Liposarcoma: A Series of 120 Cases With Emphasis on Morphologic Variants.
Gjorgova Gjeorgjievski S, Thway K, Dermawan JK, John I, Fisher C, Rubin BP, Jenkins S, Thangaiah JJ, Folpe AL, Fritchie KJ. Gjorgova Gjeorgjievski S, et al. Am J Surg Pathol. 2022 Dec 1;46(12):1700-1705. doi: 10.1097/PAS.0000000000001962. Epub 2022 Aug 26. Am J Surg Pathol. 2022. PMID: 36006773
Pleomorphic liposarcoma (PLPS) is a highly aggressive sarcoma comprising variable numbers of pleomorphic lipoblasts mixed with undifferentiated pleomorphic sarcoma (UPS)-like areas. ...The presence of epithelioid areas was also statistica …
Pleomorphic liposarcoma (PLPS) is a highly aggressive sarcoma comprising variable numbers of pleomorphic lipoblasts mix …
Rare pulmonary neoplasms.
Miller DL, Allen MS. Miller DL, et al. Mayo Clin Proc. 1993 May;68(5):492-8. doi: 10.1016/s0025-6196(12)60199-2. Mayo Clin Proc. 1993. PMID: 8386792
The histopathologic types of these rare pulmonary neoplasms were non-Hodgkin's lymphoma (41%), carcinosarcoma (20%), mucoepidermoid carcinoma (15%), malignant fibrous histiocytoma (5%), malignant melanoma (4%), fibrosarcoma (4%), leiomyosarcoma (4%), a …
The histopathologic types of these rare pulmonary neoplasms were non-Hodgkin's lymphoma (41%), carcinosarcoma (20%), mucoepidermoid carcinom …
84 results