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2005 2
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Page 1
AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells.
Zhang D, Zhao T, Ang HS, Chong P, Saiki R, Igarashi K, Yang H, Vardy LA. Zhang D, et al. Genes Dev. 2012 Mar 1;26(5):461-73. doi: 10.1101/gad.182998.111. Genes Dev. 2012. PMID: 22391449 Free PMC article.
We describe a new role for Amd1 (adenosyl methionine decarboxylase), a key enzyme in the polyamine synthesis pathway, in regulating both ESC self-renewal and differentiation to the neural lineage. Amd1 is highly expressed in …
We describe a new role for Amd1 (adenosyl methionine decarboxylase), a key enzyme in the polyamine synthesis pathway, in regul …
Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP.
Zhang D, Yang S, Toledo EM, Gyllborg D, Saltó C, Carlos Villaescusa J, Arenas E. Zhang D, et al. Sci Signal. 2017 Aug 22;10(493):eaal4165. doi: 10.1126/scisignal.aal4165. Sci Signal. 2017. PMID: 28831020
Using embryonic and mDA neurons, midbrain tissue from mice, and differentiated human neural stem cells, we investigated the mechanisms controlling the survival of mDA neurons. We found that the extracellular matrix protein lamin …
Using embryonic and mDA neurons, midbrain tissue from mice, and differentiated human neural stem cells, w …
A fluorescent glycolipid-binding peptide probe traces cholesterol dependent microdomain-derived trafficking pathways.
Steinert S, Lee E, Tresset G, Zhang D, Hortsch R, Wetzel R, Hebbar S, Sundram JR, Kesavapany S, Boschke E, Kraut R. Steinert S, et al. PLoS One. 2008 Aug 13;3(8):e2933. doi: 10.1371/journal.pone.0002933. PLoS One. 2008. PMID: 18716682 Free PMC article.
Using quantitative time-course colocalization in live cells, we show that the uptake and intracellular trafficking route of SBD is unlike that of either the non-raft marker Transferrin or the raft markers CtxB and Flotillin2-GFP. ...We show that SBD binding t …
Using quantitative time-course colocalization in live cells, we show that the uptake and intracellular trafficking route of SBD is un …
Oltipraz-induced phase 2 enzyme response conserved in cells lacking mitochondrial DNA.
Chua YL, Zhang D, Boelsterli U, Moore PK, Whiteman M, Armstrong JS. Chua YL, et al. Biochem Biophys Res Commun. 2005 Nov 11;337(1):375-81. doi: 10.1016/j.bbrc.2005.09.059. Biochem Biophys Res Commun. 2005. PMID: 16188238
Glutathione (GSH) levels (total and mitochondrial) and glutathione S-transferase (GST) activity were significantly increased after pretreatment with oltipraz in both parental (rho+) and rho0 cells, and both cell lines were resistant to mitochondrial oxidation …
Glutathione (GSH) levels (total and mitochondrial) and glutathione S-transferase (GST) activity were significantly increased after pr …
Nitric oxide protects against mitochondrial permeabilization induced by glutathione depletion: role of S-nitrosylation?
Whiteman M, Chua YL, Zhang D, Duan W, Liou YC, Armstrong JS. Whiteman M, et al. Biochem Biophys Res Commun. 2006 Jan 6;339(1):255-62. doi: 10.1016/j.bbrc.2005.10.200. Epub 2005 Nov 10. Biochem Biophys Res Commun. 2006. PMID: 16297871
Nitric oxide (NO) is known to mediate a multitude of biological effects including inhibition of respiration at cytochrome c oxidase (COX), formation of peroxynitrite (ONOO-) by reaction with mitochondrial superoxide (O2*-), and S-nitrosylation of proteins. In this s …
Nitric oxide (NO) is known to mediate a multitude of biological effects including inhibition of respiration at cytochrome c oxidase ( …
Is antioxidant potential of the mitochondrial targeted ubiquinone derivative MitoQ conserved in cells lacking mtDNA?
Lu C, Zhang D, Whiteman M, Armstrong JS. Lu C, et al. Antioxid Redox Signal. 2008 Mar;10(3):651-60. doi: 10.1089/ars.2007.1865. Antioxid Redox Signal. 2008. PMID: 17999633
Furthermore, the antioxidant effect of MitoQ is conserved in cells lacking mitochondrial DNA, indicating that its antioxidant properties do not depend on a functional electron transport chain (ETC). ...
Furthermore, the antioxidant effect of MitoQ is conserved in cells lacking mitochondrial DNA, indicating that its antioxidant propert …
A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons.
Zhang D, Pekkanen-Mattila M, Shahsavani M, Falk A, Teixeira AI, Herland A. Zhang D, et al. Biomaterials. 2014 Feb;35(5):1420-8. doi: 10.1016/j.biomaterials.2013.11.028. Epub 2013 Nov 27. Biomaterials. 2014. PMID: 24290439 Free article.
We demonstrate how a three dimensional (3D) culture of stem cell derived neurons can induce in vivo like responses related to Alzheimer's disease, not recapitulated with conventional 2D cultures. To acquire a neura …
We demonstrate how a three dimensional (3D) culture of stem cell derived neurons can induce in vivo like …
Bax and the mitochondrial permeability transition cooperate in the release of cytochrome c during endoplasmic reticulum-stress-induced apoptosis.
Zhang D, Armstrong JS. Zhang D, et al. Cell Death Differ. 2007 Apr;14(4):703-15. doi: 10.1038/sj.cdd.4402072. Epub 2006 Dec 15. Cell Death Differ. 2007. PMID: 17170750
Here we show that ER stress induced by the Ca(2+)-ATPase inhibitor thapsigargin (THG) activates cytochrome c-dependent apoptosis through cooperation between Bax and the mitochondrial permeability transition (MPT) in human leukemic CEM cells. ...Our results show that …
Here we show that ER stress induced by the Ca(2+)-ATPase inhibitor thapsigargin (THG) activates cytochrome c-dependent apoptosis through …
The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction.
Zhang D, Lu C, Whiteman M, Chance B, Armstrong JS. Zhang D, et al. J Biol Chem. 2008 Feb 8;283(6):3476-3486. doi: 10.1074/jbc.M707528200. Epub 2007 Dec 5. J Biol Chem. 2008. PMID: 18056990 Free article.
Here we show that the MPT regulates the release of cytochrome c for apoptosis during endoplasmic reticulum (ER) stress by remodeling the cristae junction (CJ). CEM cells, HCT116 colon cancer cells, and murine embryo fibroblast cells were treated with the ER s …
Here we show that the MPT regulates the release of cytochrome c for apoptosis during endoplasmic reticulum (ER) stress by remodeling the cri …
Alternate raft pathways cooperate to mediate slow diffusion and efficient uptake of a sphingolipid tracer to degradative and recycling compartments.
Zhang D, Manna M, Wohland T, Kraut R. Zhang D, et al. J Cell Sci. 2009 Oct 15;122(Pt 20):3715-28. doi: 10.1242/jcs.051557. Epub 2009 Sep 22. J Cell Sci. 2009. PMID: 19773361
Diffusion measurements of SBD at the cell surface by fluorescence correlation spectroscopy suggest that cdc42- and flotillin-associated uptake sites both correspond to domains of intermediate mobility, but that they can cooperate to form low-mobility, efficiently in …
Diffusion measurements of SBD at the cell surface by fluorescence correlation spectroscopy suggest that cdc42- and flotillin-associat …